ToolsStudents at Arc

Central to Arc’s mission is not only developing state-of-the-art technologies, but also making them widely available to accelerate biomedical research across the globe. At Arc’s Tools Portal, we’re sharing our growing list of computational tools developed by Arc scientists, along with supporting publications, documentation, and code. 

Check back often, as we’ll be posting new tools as they are launched, and feel free to contact us at with any questions.

Software & Tools

Algorithms, software, analysis pipelines, and machine learning models to extract new insights, accelerate discovery, predict biological outcomes, and visualize results.

Machine Learning Tools

Evo: DNA Foundation Model

Evo is a biological foundation model capable of generative design from molecular to genome scale at single-nucleotide resolution.
Preprint, February 2024

Genome Engineering Tools

Cas13d Guide Design Tool

Built from the largest Cas13d knockdown dataset to date, Arc's deep learning-powered Cas13d Guide RNA Selection Tool nominates high-efficiency guide sequences and any custom RNA sequences for knocking down your transcript of interest across human, mouse, other model organisms, and custom sequences. Wei et al, Cell Systems 2023


ScreenPro2 is a tool for flexible pooled CRISPR screen analysis.