We are interested in programming biology at multiple levels of scale. Our contributions in this area include the early development of CRISPR-Cas9 for human genome editing, the discovery and development of CRISPR-Cas13d for transcriptome engineering, and the discovery and development of multiple classes of recombinases (bridge RNA-guided recombinases and new large serine recombinases) for large-scale DNA rearrangement and genome design. We are interested in applying these tools to manipulate higher-levels of biological organization at the tissue and physiological levels.
We aim to push the boundaries of synthetic biology, which we define broadly as anything that doesn‘t happen naturally. First, we think backwards from the desired application, such as a major unmet therapeutic need, and develop platform solutions that enable new kinds of synthetic manipulations. Recent areas of interest include cell type-specific control of biological perturbations, turning the dial on epigenetic memory, and manipulation of RNA splicing for writing RNAs directly into the endogenous transcriptome. We are also thinking about synthetic hormones, rational nutrition, and interoception.
Masahiro Hiraizumi, Januka S Athukoralage, Nicholas T Perry, Eisuke Tsujimoto, Nami Shiojiri, Naoto Nagahata, Lauren Lee, Gwanggyu Sun, Matthew G Durrant, Sita S Chandrasekaran, Silvana Konermann, Keitaro Yamashita, Patrick D Hsu, Hiroshi Nishimasu
Hyungseok C Moon, Michael H Herschl, Alessandra Sclip, Vincent Q Tran, April Pawluk, Silvana Konermann, Patrick D Hsu
Garyk Brixi, Matthew G Durrant, Jerome Ku, Mohsen Naghipourfar, Michael Poli, Gwanggyu Sun, Greg Brockman, Daniel Chang, Alison Fanton, Gabriel A Gonzalez, Samuel H King, David B Li, Aditi T Merchant, Eric Nguyen, Chiara Ricci-Tam, David W Romero, Jonathan C Schmok, Ali Taghibakhshi, Anton Vorontsov, Brandon Yang, Myra Deng, Liv Gorton, Nam Nguyen, Nicholas K Wang, Michael T Pearce, Elana Simon, Etowah Adams, Zachary J Amador, Euan A Ashley, Stephen A Baccus, Haoyu Dai, Steven Dillmann, Stefano Ermon, Daniel Guo, Michael H Herschl, Rajesh Ilango, Ken Janik, Amy X Lu, Reshma Mehta, Mohammad RK Mofrad, Madelena Y Ng, Jaspreet Pannu, Christopher Ré, John St John, Jeremy Sullivan, Joseph Tey, Ben Viggiano, Kevin Zhu, Greg Zynda, Daniel Balsam, Patrick Collison, Anthony B Costa, Tina Hernandez-Boussard, Eric Ho, Ming-Yu Liu, Thomas McGrath, Kimberly Powell, Sudarshan Pinglay, Dave P Burke, Hani Goodarzi, Patrick D Hsu, Brian L Hie
Vincent Q Tran, Matthew Nemeth, Liam J Bartie, Sita S Chandrasekaran, Alison Fanton, Hyungseok C Moon, Brian L Hie, Silvana Konermann, Patrick D Hsu
Sita S Chandrasekaran, Cyrus Tau, Becky Xu Hua Fu, Matthew Nemeth, Liam Bartie, April Pawluk, Silvana Konermann, Patrick D Hsu
Alison Fanton, Liam J Bartie, Juliana Q Martins, Vincent Q Tran, Laine Goudy, Courtney Kernick, Matthew G Durrant, Jingyi Wei, Zev Armour-Garb, April Pawluk, Silvana Konermann, Alexander Marson, Luke A Gilbert, Theodore L Roth, Patrick D Hsu
Nicholas T Perry, Liam J Bartie, Dhruva Katrekar, Gabriel A Gonzalez, Matthew G Durrant, James J Pai, Alison Fanton, Juliana Q Martins, Masahiro Hiraizumi, Chiara Ricci-Tam, Hiroshi Nishimasu, Silvana Konermann, Patrick D Hsu
Yusuf H Roohani, Tony J Hua, Po-Yuan Tung, Lexi R Bounds, Feiqiao B Yu, Alexander Dobin, Noam Teyssier, Abhinav Adduri, Alden Woodrow, Brian S Plosky, Reshma Mehta, Benjamin Hsu, Jeremy Sullivan, Chiara Ricci-Tam, Nianzhen Li, Julia Kazaks, Luke A Gilbert, Silvana Konermann, Patrick D Hsu, Hani Goodarzi, Dave P Burke
Abhinav Adduri, Dhruv Gautam, Beatrice Bevilacqua, Alishba Imran, Rohan Shah, Mohsen Naghipourfar, Noam Teyssier, Rajesh Ilango, Sanjay Nagaraj, Chiara Ricci-Tam, Chris Carpenter, Vishvak Subramanyam, Aidan Winters, Mingze Dong, Sravya Tirukkovalur, Jeremy Sullivan, Brian Plosky, Basak Eraslan, Nicholas D Youngblut, Jure Leskovec, Luke A Gilbert, Silvana Konermann, Patrick D Hsu, Alexander Dobin, Dave P Burke, Hani Goodarzi, Hani Goodarzi, Yusuf Husein Roohani
Eric Nguyen, Michael Poli, Matthew G. Durrant, Brian Kang, Dhruva Katrekar, David B. Li, Liam J. Bartie, Armin W. Thomas, Samuel H. King, Garyk Brixi, Jeremy Sullivan, Madelena Y. Ng, Ashley Lewis, Aaron Lou, Stefano Ermon, Stephen A. Baccus, Tina Hernandez-Boussard, Christopher Ré, Patrick D. Hsu and Brian L. Hie.
Matthew G. Durrant*, Nicholas T. Perry*, James J. Pai, Aditya R. Jangid, Januka S. Athukoralage, Masahiro Hiraizumi, John P. McSpedon, April Pawluk, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu
Masahiro Hiraizumi*, Nicholas T. Perry, Matthew G. Durrant, Teppei Soma, Naoto Nagahata, Sae Okazaki, Januka S. Athukoralage, Yukari Isayama, James J. Pai, April Pawluk, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu
Matthew G. Durrant, Alison Fanton, Josh Tycko, Michaela Hinks, Sita S. Chandrasekaran, Nicholas T. Perry, Julia Schaepe, Peter P. Du, Peter Lotfy, Michael C. Bassik, Lacramioara Bintu, Ami S. Bhatt & Patrick D. Hsu
Scott B. Biering, Sylvia A. Sarnik, Eleanor Wang, James R. Zengel, Sarah R. Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R. Jangid, Connor V. Duffy, Jin Wei, Rodney C. Gilmore, Mia Madel Alfajaro, Madison S. Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H. Yamashiro, Julia A. Belk, Adam Begeman, Jessica C. Stark, D. Judy Shon, Douglas M. Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S. Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R. Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C. Aguilar, Andreas S. Puschnik, Brian Button, Benjamin A. Pinsky, Catherine A. Blish, Ralph S. Baric, Wanda K. O’Neal, Carolyn R. Bertozzi, Craig B. Wilen, Richard C. Boucher, Jan E. Carette, Sarah A. Stanley, Eva Harris, Silvana Konermann & Patrick D. Hsu
Patrick Hsu is Co-Founder of the Arc Institute and Assistant Professor of Pathology at Stanford University. The Hsu lab works at the intersection of biology and machine learning to develop technologies for biological design. Recent contributions include the Evo series of genome foundation models and the first universally programmable DNA recombinases. Patrick received A.M. and Ph.D. degrees from Harvard University and the Broad Institute of MIT and Harvard, where he was an early pioneer of CRISPR-Cas9 technologies for genome editing. His research has been recognized by awards from the New York Times (Good Tech Award), The Atlantic (Most Important Breakthrough of 2024), Forbes (5 Most Important Medical Breakthroughs of 2024, 30 Under 30), MIT Technology Review Innovators under 35, Rainwater Foundation, and Amgen. He serves on the scientific advisory board of Amgen and the board of Stylus Medicine, and cofounded Fast Grants for rapid science funding.
Massachusetts General Hospital/Harvard Medical School (Postdoc) & University of Wisconsin-Madison (PhD in Biochemistry)
MSc Dance Science, Trinity Laban Conservatoire of Music & Dance
Ph.D., Microbiology and Immunology, Stanford University
Stanford (Postdoc) & Open University of London (PhD)
Stanford University (Postdoc) & University of Toronto (PhD in Pathobiology)
Rice University (Postdoc), Harvard Medical School (PhD, Biological & Biomedical Sciences)
Perelman School of Medicine (Postdoc), Tsinghua University (PhD, Computer Science)
Ph.D., Bioengineering, Stanford University
Seoul National University (PhD in Biophysics)
UC Berkeley Molecular and Cell Biology PhD Program
UC Berkeley Bioengineering PhD Program
BS, Biomedical Engineering, Columbia University
B.S., Biology, Santa Clara University
Research Associate, MPhil, Biological Sciences, University of Cambridge
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About Opportunities in Our Lab
The Hsu Lab works at the intersection of biology, engineering, and AI. We develop programmable molecular technologies for precise genome editing and design, including CRISPR systems, Bridge recombinases, and large serine recombinases. Beyond the genome, we aim to modulate physiology through synthetic peptides, microbiome engineering, and rational nutrition. Finally, we merge advances in biology and AI to mine the metagenomic sequence space, enable generative genome design, and build towards a virtual cell.
We welcome inquiries from motivated researchers at all career stages who are passionate about “programming biology” (at the genome level and beyond) and its applications to human health.
Current openings are posted on the Arc Institute Careers page.
If you see a position that matches your interests and qualifications, please apply directly through our application portal. All posted positions are managed through that system.
If you don't see a posted position but are interested in joining the lab, or if you're exploring opportunities for the future, please email us at [email protected].
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