Get Arc research delivered to your inbox:

Sign up to receive Arc Institute updates

Core Facilities

Palo Alto, CA

Postdoctoral Researcher, Jain Lab

Postdoctoral Researcher, Horns Lab

Postdoctoral Researcher, Zhou Lab

Postdoctoral Researcher, ML for Biology, Hsu Lab

Postdoctoral Researcher, Biological Design, Hsu Lab

Research Associate II, Konermann Lab

Lab Manager, Hie & Pluvinage Labs

Research Associate II, Horns Lab

In Vivo Research Associate II, Konermann Lab

Postdoctoral Researcher, Neuro-Immune Interactions, Pluvinage Lab

Core Laboratories

Faculty & Fellows

FP&A Manager

Scientific Program Manager Lead

People Operations & Compensation Lead

Chief of Staff

Executive Assistant

Laboratory Operation Assistant (Temp to Perm)

General Counsel

Operations

Director, Machine Learning, Alzheimer's Disease Initiative

Director, Machine Learning, Virtual Cell Initiative

Senior Research Associate, HPC Production (Fixed-Term Contract)

Senior Research Associate, Functional Genomics

Senior Research Associate, NGS - Genomics Platform (Fixed-Term Contract)

Scientist, Computational Biology

Senior Director, Disease Biology

Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)

Technology Centers

No Department

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Chief of Staff serves as a scientific and strategic partner, proxy, and &quot;shared brain&quot; to the Institute&#39;s Executive Director and Core Investigator. This is a technical, full-time role for someone who can engage substantively with the science, from CRISPR-based transcriptome engineering and functional genomics to computational modeling and disease biology, and translate that engagement into sharp decision-making, program execution, and cross-disciplinary coordination. On a given day you might pressure-test the experimental design or interpretation of a scientific project, distill complex inputs into clear decision frameworks and meeting agendas, scope and foster cross-lab collaboration, prepare a scientifically rigorous external deliverable, and protect the Executive Director&#39;s time for deep work by optimizing her schedule. You will create leverage for the Executive Director&#39;s highest-priority scientific and organizational work by owning her operating rhythm, helping drive technical initiatives to completion, and connecting the right people, data, and resources to unblock science. You will be trusted with confidential scientific and organizational information and empowered to act on her behalf, so scientific judgment, discretion, and follow-through are essential.&lt;/p&gt;
&lt;p&gt;The Executive Director is a Core Investigator and Assistant Professor of Biochemistry at Stanford whose laboratory studies the molecular pathways driving neurodegenerative disease with the goal of developing rationally targeted therapeutics. Her group develops CRISPR-based technologies to directly perturb the transcriptomic landscape of the cell, including engineered type VI RNA-targeting CRISPR-Cas systems, and applies them across functional genomic screens and disease models. She operates as a biologist and PI, scientific leader for our Institute Initiatives, and overall institutional leader, and needs a Chief of Staff who can deeply understand and support all three.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love engaging with science deeply across functional genomics, neuroscience and computational science&lt;/li&gt;
&lt;li&gt;You are fluent across the experimental/computational divide. You are comfortable talking with wet-lab scientists and computational biologists alike and can help them collaborate effectively.&lt;/li&gt;
&lt;li&gt;You are highly organized and 10/10 detail-oriented&lt;/li&gt;
&lt;li&gt;You are a natural information gatherer, synthesizer and connector. You proactively seek out the right people and data, ask incisive technical questions, and turn a complex, ambiguous picture into clear options and recommendations.&lt;/li&gt;
&lt;li&gt;You build trust and enable others. You are persuasive but tactful, bringing diplomacy, curiosity, and positive energy to every interaction.&lt;/li&gt;
&lt;li&gt;You love structuring hard problems. You break ambiguous research initiatives into clear workstreams and deliverables, identify dependencies, and anticipate bottlenecks before anyone else.&lt;/li&gt;
&lt;li&gt;You are a strong writer and communicator, able to translate technical work for non-specialist audiences without sacrificing accuracy.&lt;/li&gt;
&lt;li&gt;You are unflappable and solution-oriented amid ambiguity, shifting priorities, and rapid change, and you handle confidential information with discretion.&lt;/li&gt;
&lt;li&gt;You are mission-oriented and energized by accelerating science through great organization, coordination, and partnership.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Serve as a scientific and strategic daily thought partner to the Executive Director, engaging critically with scientific work across the lab, institute and external partnerships, providing structure for the work and representing her priorities internally and externally.&lt;/li&gt;
&lt;li&gt;Own the operating rhythm of the Executive Director’s office, including a complex, shifting schedule and the prioritization of conflicting technical and organizational demands. This includes a small amount of administrative work for the Executive director.&lt;/li&gt;
&lt;li&gt;Gather and synthesize technical information and open decisions from across the Institute into clearly framed options, trade-offs, and recommendations, so the Executive Director can make well-informed scientific and strategic decisions quickly.&lt;/li&gt;
&lt;li&gt;Design strategic and effective meeting and offsite pre-reads, meeting agendas and meeting followup for Arc’s leadership team as well as scientific teams&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Drive high-priority scientific programs, collaborations and special projects from inception through execution, anticipating experimental, computational, and organizational bottlenecks before they arise in close collaboration with the Scientific Program Management function at Arc which runs ongoing OKR planning and project management for our technology centers.&lt;/li&gt;
&lt;li&gt;Partner with the Executive Director and leadership team on defining annual and longer term strategic goals for the institute&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Unblock science by organizing and stewarding scientific collaborations, within the Institute and with external partners, and by making the right connections between people, data, platforms, and reagents.&lt;/li&gt;
&lt;li&gt;Translate complex technical work for varied audiences, from expert scientific staff to institutional leadership, funders, and public-facing communications, without losing rigor.&lt;/li&gt;
&lt;li&gt;Handle confidential scientific and organizational information with care, thoughtfulness, and discretion at all times.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A Ph.D. (or equivalent research training) with a demonstrated scientific track record, or comparable technical depth from a consulting or founder path, plus 5-12+ years of experience, sufficient to serve as a genuine scientific thought partner. This role spans multiple levels; final leveling and compensation will be determined based on the candidate&#39;s experience, scope of prior responsibility, and demonstrated impact.&lt;/li&gt;
&lt;li&gt;Background in one or more relevant biology areas (e.g., genome or transcriptome engineering, functional genomics, neuroscience, molecular/cell biology, multi-omics, or computational biology).&lt;/li&gt;
&lt;li&gt;Demonstrated strength in technical information gathering, stakeholder and dependency mapping and management, and synthesizing complex scientific information into clear options and actionable recommendations for decision makers.&lt;/li&gt;
&lt;li&gt;Track record of managing complex, cross-functional projects in a research environment from inception through execution, balancing competing priorities while maintaining focus on strategic objectives.&lt;/li&gt;
&lt;li&gt;Evidence of translating technical or scientific work for non-specialist audiences (e.g., institutional or public-facing writing and presentations, not academic papers).&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills, with proven ability to engage credibly with research scientists, experimentalists, computational teams, and senior leadership.&lt;/li&gt;
&lt;li&gt;Experience designing and facilitating highly effective meeting pre-reads, agendas and followups&lt;/li&gt;
&lt;li&gt;Solution-oriented and adept at navigating shifting priorities and rapid change; unflappable, proactive, and discreet.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in the life sciences or a closely related field; open to candidates from academic, consulting, or founder backgrounds and not limited to a traditional academic path.&lt;/li&gt;
&lt;li&gt;Hands-on experience with CRISPR/gene- or RNA-editing technologies, functional genomic screens, or high-throughput experimental platforms.&lt;/li&gt;
&lt;li&gt;Experience with computational biology, machine learning, or large-scale genomic data, or a demonstrated ability to partner closely with teams that do.&lt;/li&gt;
&lt;li&gt;Experience organizing scientific collaborations or programs, within an institution and with external partners, from inception through execution.&lt;/li&gt;
&lt;li&gt;Experience supporting board preparation, scientific offsites, and executive or scientific communications.&lt;/li&gt;
&lt;li&gt;Demonstrated staying power and increasing scope of responsibility over a career (people-management experience is not a prerequisite)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $160,000 to $237,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

Headquarters - 3181 Porter Drive, Palo Alto, CA

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;h2&gt;&lt;strong&gt;About the Position&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;We are searching for an exceptional scientific leader to establish a new team within Arc Institute’s Computational Technology Center, serving as the Director, Machine Learning for our Alzheimer&#39;s Disease Initiative (ADI).&amp;nbsp;&lt;/p&gt;
&lt;p&gt;This ambitious initiative spans Arc&#39;s Technology Centers and Core Investigator Laboratories and focuses on high-throughput interrogation of neurodegeneration and Alzheimer&#39;s disease mechanisms using advanced gene editing and functional genomics approaches. As the Machine Learning Research Lead, ADI, you will spearhead development of sophisticated machine learning foundation models to capture cell states and infer gene regulatory networks and causal relationships to predict therapeutic interventions.&lt;/p&gt;
&lt;p&gt;This position offers the rare opportunity to build and lead a world-class team while making direct contributions to understanding and potentially treating Alzheimer&#39;s disease through state-of-the-art computational biology and machine learning approaches.&lt;/p&gt;
&lt;h2&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;You are passionate about machine learning and computational biology&lt;/strong&gt;, with expertise in applying cutting edge ML approaches to biological systems&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You excel at developing interpretable machine learning approaches&lt;/strong&gt;, such as variational inference and causal modeling methods&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You are excited about building and leading a technical team while remaining hands-on&lt;/strong&gt; with foundation model development and implementation.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You thrive in collaborative, multidisciplinary environments&lt;/strong&gt; and enjoy working with both computational scientists and wet lab biologists&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You are a continuous learner who stays current with the latest developments,&lt;/strong&gt; in both machine learning and neuroscience&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;strong&gt;In This Position, You Will&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;Attract, build and lead a team of exceptional machine learning research scientists dedicated to developing foundation models for cellular systems in Alzheimer&#39;s disease&lt;/li&gt;
&lt;li&gt;Develop and execute on a roadmap of interpretable machine learning approaches to understand disease mechanisms, with emphasis on variational inference, causal modeling, as well as modern transformer- and diffusion-based architectures&lt;/li&gt;
&lt;li&gt;Work closely with experimentalists on brain organoid/spheroid cellular models as well as &lt;em&gt;in vivo&lt;/em&gt; models, working with scRNA-seq, Perturb-seq and other datasets to unravel causal gene pathways relevant to Alzheimer’s disease&lt;/li&gt;
&lt;li&gt;Develop predictive modeling approaches to identify how perturbations can move cell states from high risk Alzheimer’s profiles back to healthy / low risk states&lt;/li&gt;
&lt;li&gt;Collaborate closely with experimental biologists to ensure ML models are grounded in disease biology and can feedback into future experimental strategies&lt;/li&gt;
&lt;li&gt;Foster collaborations with external partners in the computational biology and neuroscience communities&lt;/li&gt;
&lt;li&gt;Publish high-impact research through preprints, journal publications, open source code, and presentations at leading conferences&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;strong&gt;Required Qualifications&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, or related quantitative field&lt;/li&gt;
&lt;li&gt;7+ years of relevant experience with a minimum of 3 years of people management experience&lt;/li&gt;
&lt;li&gt;Strong research background with experience in academic settings (university, research institute) and/or biotech/pharmaceutical industry with a focus on scientific innovation&lt;/li&gt;
&lt;li&gt;Proven expertise in machine learning applications to biological datasets, with specific experience in single-cell profiling data and foundation model development&lt;/li&gt;
&lt;li&gt;Deep experience with interpretable machine learning approaches for biological systems (e.g. variational inference methods).&lt;/li&gt;
&lt;li&gt;Advanced technical skills in machine learning frameworks, particularly PyTorch, and ideally experience with model training at scale&lt;/li&gt;
&lt;li&gt;Publications in top-tier journals in computational biology and machine learning&lt;/li&gt;
&lt;li&gt;Excellent communication skills with ability to present complex machine learning concepts to both computational and biological audiences&lt;/li&gt;
&lt;li&gt;Proven ability to remain technically hands-on while providing effective team leadership, mentorship, and management&lt;/li&gt;
&lt;li&gt;Background in neurodegeneration research including familiarity with Alzheimer&#39;s disease datasets, pathways, networks, disease mechanisms, and eQTL analysis is a plus&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $380,000-$420,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Why this position could be the best job you’ve ever had?&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work at the center of AIxBio with the potential to revolutionize drug discovery for the world.&lt;/li&gt;
&lt;li&gt;Work in a unique environment that incorporates both wet lab data generation and frontier AI modelling in an active learning loop.&lt;/li&gt;
&lt;li&gt;Join a new type of research org that fuses high-velocity execution of a startup with the intellectual rigor of a world-class academic institute, with a long runway to tackle some of the hardest - and highest potential -&amp;nbsp; challenges in science today.&lt;/li&gt;
&lt;li&gt;Collaborate with some of the most accomplished scientists and entrepreneurs in the world.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are searching for an innovative scientific leader experienced in building predictive models based on single-cell genomic data. The chosen candidate will spearhead the development and application of advanced machine learning models tailored for perturbative gene expression modeling, in the context of Arc’s virtual cell initiative.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about machine learning, ideally with experience or strong interest in biology and single-cell genomics.&lt;/li&gt;
&lt;li&gt;You want to develop highly innovative and accurate biology-inspired multimodal machine learning models.&lt;/li&gt;
&lt;li&gt;You are excited about collaborating with a multidisciplinary team of computational and experimental biologists at Arc.&lt;/li&gt;
&lt;li&gt;You are a strong communicator, capable of translating complex technical concepts at the intersection of machine learning and biology.&lt;/li&gt;
&lt;li&gt;You are a continuous learner.&lt;/li&gt;
&lt;li&gt;You are interested in recruiting and managing your own group of scientists and engineers as well as mentoring and training for other scientists.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead/build a team of 6 ML research scientists and engineers augmented with undergrad/masters/PhD students to contribute to the development of a state-of-the-art foundation model and agentic framework for understanding how cells respond to perturbations.&lt;/li&gt;
&lt;li&gt;Work in an active learning loop with Arc’s wet lab scientists to shape the world&#39;s largest and most diverse set of single cell training data across many cell contexts.&lt;/li&gt;
&lt;li&gt;Collaborate closely with other research groups to integrate genomics, functional track,and omics data more broadly beyond scRNA-seq data and Perturb-seq&lt;/li&gt;
&lt;li&gt;Stay up to date on the latest in frontier ML research and pioneer new architectures and approaches.&lt;/li&gt;
&lt;li&gt;The ultimate goal is to build a high utility virtual cell model for use by biologists worldwide.&amp;nbsp;We publish our breakthroughs to widely accelerate scientific progress and partner with some of the biggest names in AI.&lt;/li&gt;
&lt;li&gt;Commit to a collaborative and inclusive team environment, sharing expertise and mentoring others.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Attract the very best talent in the world to support VCI initiative goals&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computational Biology, Bioinformatics, Machine Learning, or a related field.&lt;/li&gt;
&lt;li&gt;Minimum of 5 years of experience working in/with machine learning, well versed in frameworks such as Pytorch, TensorFlow, JAX, etc.&lt;/li&gt;
&lt;li&gt;Proven experience leading research teams in a fast paced, multi-disciplinary environment.&lt;/li&gt;
&lt;li&gt;Experience with or strong interest in biology with ability to communicate and collaborate successfully with biologists and pure ML engineers.&lt;/li&gt;
&lt;li&gt;Excellent communication skills, both written and verbal, with a strong track record of presentations and publications.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $380,000-$420,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for an Executive Assistant to support both our Chief Science Officer and Chief Technology Officer, two of our most senior leaders at Arc Institute, who together oversee the efforts of about 100 scientists, engineers, and researchers – and collaborate with many more across the Institute and beyond. This person will manage active calendars, help run team offsites and events across both organizations, and act as a trusted partner who understands the pace and priorities of each leader. This is a high visibility role for someone who enjoys managing multiple priorities across two distinct teams and wants to build a real partnership with the executives they support.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You have a natural read on people and situations. You can sense when stress is building or a moment needs extra care, and you use tools like the calendar thoughtfully to protect people&#39;s time and headspace, not just fill it.&lt;/li&gt;
&lt;li&gt;You have sharp intuition for what matters. You don&#39;t need everything spelled out; you build a real understanding of the team&#39;s priorities over time and know when to make a call independently and also when to check in.&lt;/li&gt;
&lt;li&gt;You&#39;re fast to respond and quick to act. If something lands in your inbox during the day, it doesn&#39;t sit. You treat responsiveness as a core part of the job, not an afterthought.&lt;/li&gt;
&lt;li&gt;You&#39;re detail-oriented. You notice the small things and make sure nothing falls through the cracks.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Manage complex, overlapping calendars for two executives, using judgment to protect their time, resolve conflicts, and anticipate scheduling issues before they become problems&lt;/li&gt;
&lt;li&gt;Coordinate all logistics for work related travel for both executives, including flights, hotels, and itineraries (personal calendars and personal travel are not part of this role)&lt;/li&gt;
&lt;li&gt;Own the planning and execution of Tech Center offsites and recurring team events, partnering with the Science Program Manager and other stakeholders on agenda and content while owning venue selection, catering, and day of logistics&lt;/li&gt;
&lt;li&gt;Partner with the Science Program Manager on Tech Center recurring team social events, all hands meetings, including coordinating pre-reads and related communications&lt;/li&gt;
&lt;li&gt;Identify and take on cleanly scoped projects that reduce the load on the broader team, such as reorganizing shared documentation&lt;/li&gt;
&lt;li&gt;Communicate directly, and on behalf of both executives, with internal teams, external partners, and scientific staff&lt;/li&gt;
&lt;li&gt;Balance competing needs and rhythms across two teams of different sizes and seniority, adjusting as priorities shift week to week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor’s degree and a minimum of 5 years of experience&lt;/li&gt;
&lt;li&gt;Administrative experience supporting a C-suite or senior executive at a company or large organization (this is not a personal assistant role supporting an individual)&lt;/li&gt;
&lt;li&gt;Experience managing calendars and schedules for an executive with a high volume of meetings&lt;/li&gt;
&lt;li&gt;Able to be onsite a minimum of 3 days per week at our Palo Alto office, with additional time onsite expected during offsites, events, and other high activity weeks&lt;/li&gt;
&lt;li&gt;Adept at handling confidential and sensitive information with care, thoughtfulness and discretion.&lt;/li&gt;
&lt;li&gt;Open to learning and adopting new organizational tools as needed, including Asana and AI tools such as Claude&lt;/li&gt;
&lt;li&gt;Comfortable operating with ambiguity and occasional urgency, and able to stay steady when plans change quickly&lt;/li&gt;
&lt;li&gt;Proficient with standard office and organizational software (e.g. Google Suite)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience supporting two or more leaders at the same time&lt;/li&gt;
&lt;li&gt;Experience in a fast paced startup environment or a large, complex organization&lt;/li&gt;
&lt;li&gt;Curiosity about science or research (a science background is not required)&lt;/li&gt;
&lt;li&gt;Experience planning and running offsites, team events, or conferences from start to finish&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The base salary range for this position is $105,250 to $148,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/h3&gt;
&lt;p&gt;We are seeking an independent and analytical FP&amp;amp;A Manager to join our Financial Planning &amp;amp; Analysis (FP&amp;amp;A) team. This critical role will partner closely with key budget owners in our Technology Centers and Core Labs, driving the annual budgeting process, project-specific forecasting, and strategic decision-making. The ideal candidate will possess a strong foundation in financial modeling, experience at a science organization, and a proven ability to translate data into actionable insights for leadership.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;You are deeply analytical with a knack for effectively communicating that information visually and verbally&lt;/li&gt;
&lt;li&gt;You are a team player; you like to work as a team to help people get their jobs done&lt;/li&gt;
&lt;li&gt;You are detail-oriented and have a passion for organized processes and structured systems&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are familiar with our science and motivated about Arc’s mission&lt;/li&gt;
&lt;li&gt;You are a life long learner&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Partner directly with budget owners (specifically CSO, CTO, and COO organizations) to ensure financial plans align with strategic goals and provide detailed variance analysis against prior forecasts and budget.&lt;/li&gt;
&lt;li&gt;Develop scenario-driven financial models for key Institute Initiatives, new scientific programs, and capital expenditures.&lt;/li&gt;
&lt;li&gt;Drive continuous improvement in FP&amp;amp;A processes, reporting automation, and financial system utilization (e.g., Netsuite, Prendio).&lt;/li&gt;
&lt;li&gt;Help develop and present Arc’s annual operating budget, long-range strategic plans, and forecasts for our Institute Initiatives, research labs, and operational units.&lt;/li&gt;
&lt;li&gt;Support strategic vendor negotiations to reduce our operational costs.&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor&#39;s degree in Finance, Economics, or a related quantitative field and 5+ years of experience in a demanding finance or analytical role.&lt;/li&gt;
&lt;li&gt;Demonstrated experience leading and executing the core functions of corporate FP&amp;amp;A, including budgeting, forecasting, and reporting, ideally within a fast-paced Technology or Biotechnology company.&lt;/li&gt;
&lt;li&gt;Prior experience as an Investment Banking Analyst (2-3 years) OR experience as a Consultant at a major/large consulting firm program (2-3 years). This experience must have provided deep exposure to financial analysis, rigorous modeling techniques, and effective communication of data.&lt;/li&gt;
&lt;li&gt;Exceptional proficiency with spreadsheets (advanced modeling, pivot tables, lookups, chart visualizations).&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Educational background (e.g., degree or advanced coursework) or professional experience in the Biosciences, Biotech, and/or related fields is highly desirable.&lt;/li&gt;
&lt;li&gt;Experience with financial planning systems (e.g., Netsuite Planning, Adaptive Planning) is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $116,750 to $144,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is seeking a General Counsel to serve as a strategic legal advisor and trusted peer to leadership. Reporting to Co-Founder and Executive Director, Silvana Konermann, the General Counsel will help identify and execute the legal pathways that enable Arc to pursue ambitious scientific and institutional goals. This role requires a commercially sharp, highly proactive lawyer with strong judgment, excellent instincts, and the ability to move complex matters forward with urgency and rigor.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A strategic, solutions-oriented lawyer who thrives on solving difficult problems and moving complex matters forward.&lt;/li&gt;
&lt;li&gt;Highly proactive, resourceful, and comfortable taking ownership in ambiguous environments.&lt;/li&gt;
&lt;li&gt;A fast learner who can quickly develop fluency in new scientific, operational, and institutional domains.&lt;/li&gt;
&lt;li&gt;A strong communicator who translates legal risk into practical advice and decisive next steps.&lt;/li&gt;
&lt;li&gt;Able to balance rigorous legal analysis with a strong bias toward action and outcomes.&lt;/li&gt;
&lt;li&gt;A collegial, trusted leader and peer who earns confidence quickly, contributes constructively, and helps teams make sound decisions.&lt;/li&gt;
&lt;li&gt;Confident engaging with senior leaders and external counterparties in high-stakes settings while maintaining professionalism, discretion, and good judgment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead legal strategy for complex collaborations, partnerships, and institutional arrangements that advance Arc’s mission.&lt;/li&gt;
&lt;li&gt;Advise leadership on governance, compliance, conflicts, regulatory, and risk matters.&lt;/li&gt;
&lt;li&gt;Oversee legal agreements with academic, industry, nonprofit, and other strategic partners.&lt;/li&gt;
&lt;li&gt;Identify legal pathways that enable new initiatives while protecting the Institute’s interests.&lt;/li&gt;
&lt;li&gt;Support business development and strategic growth initiatives.&lt;/li&gt;
&lt;li&gt;Build and improve legal processes, policies, and frameworks that support speed, clarity, and responsible execution.&lt;/li&gt;
&lt;li&gt;Manage and develop a small legal team, which includes an existing IP &amp;amp; Licensing function, and supervise outside counsel as needed.&lt;/li&gt;
&lt;li&gt;Provide clear, practical, and independent counsel to senior operational and scientific leadership.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;JD and Active membership in the State Bar of California, or eligibility to practice immediately as Registered In-House Counsel in California.&lt;/li&gt;
&lt;li&gt;Experienced leader and member of an executive team&lt;/li&gt;
&lt;li&gt;Experienced people manager with track record of mentorship and skill development&lt;/li&gt;
&lt;li&gt;15+ years of relevant legal experience including significant experience in corporate, transactional, technology transfer, engineering, life sciences, or related legal work.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to advise senior stakeholders on complex legal and strategic matters.&lt;/li&gt;
&lt;li&gt;Experience leading or materially supporting high-stakes negotiations and transactions.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience structuring novel or complex legal arrangements in innovation-driven environments.&lt;/li&gt;
&lt;li&gt;Experience managing a team of IP professionals or supervising external IP counsel.&lt;/li&gt;
&lt;li&gt;Experience in biotech, life sciences, technology, or similarly fast-moving sectors.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $330,000 to $450,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking an In Vivo Research Associate II to join the &lt;a href=&quot;https://arcinstitute.org/labs/konermannlab&quot;&gt;Konermann Laboratory&lt;/a&gt; at the Arc Institute.You will collaborate closely with experienced scientists to advance in vivo projects focused on understanding brain development.&lt;/p&gt;
&lt;p&gt;This project builds on previous work in genome-scale CRISPR screening (Konermann et al., 2015; Biering et al., 2021; Wei et al., 2023; Roohani et al., 2025) and aims to combine modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function. The ideal candidate will have experience in animal handling and colony management, intracerebral injections, sample processing for single-cell RNA sequencing and spatial pipelines, and imaging. This position offers an excellent opportunity for candidates considering PhD programs, as it involves participation in all stages of a research project under the guidance of an experienced scientist.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and learning. Whether it&#39;s a new field or a new bench technique, you stay curious and enjoy stepping outside your comfort zone.&lt;/li&gt;
&lt;li&gt;You are detail-oriented. You&#39;re careful and diligent about documentation and good lab practice, and you like keeping things organized.&lt;/li&gt;
&lt;li&gt;You collaborate and help others. Science is a team effort, and you take the initiative to pitch in.&lt;/li&gt;
&lt;li&gt;You are a problem solver. Experiments rarely work the first time. You bring patience and confidence to complex technical troubleshooting.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Plan, execute, analyze, and troubleshoot experiments with a high degree of independence, with continued support from the rest of the team&lt;/li&gt;
&lt;li&gt;Perform in vivo mouse experiments, including stereotaxic surgeries, as well as IV and IP injections&lt;/li&gt;
&lt;li&gt;Collect and process tissue, including vibratome and/or cryostat sectioning, immunostaining, and imaging&lt;/li&gt;
&lt;li&gt;Comply with federal, Arc, and local IACUC/AAALAC regulations governing animal research&lt;/li&gt;
&lt;li&gt;Follow Arc&#39;s standards for code of conduct, safety, and the handling of hazardous materials, biological materials, and controlled substances&lt;/li&gt;
&lt;li&gt;Analyze and present data at subgroup meetings and seminars&lt;/li&gt;
&lt;li&gt;Maintain an organized, detailed lab notebook&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS with 2+ years of relevant experience, or MS, in molecular biology, neuroscience, or another relevant field. Relevant experience includes independent lab work during undergraduate studies&lt;/li&gt;
&lt;li&gt;Strong experience working with laboratory animals, including handling, restraint, and procedures under an approved protocol (intracranial, IV, and IP injections, as well as perfusions)&lt;/li&gt;
&lt;li&gt;Detail-oriented, with excellent organizational and time-management skills&lt;/li&gt;
&lt;li&gt;Outstanding critical thinking and problem-solving skills&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills&lt;/li&gt;
&lt;li&gt;Highly motivated and curious, with the ability to work effectively both independently and as part of a collaborative team&lt;/li&gt;
&lt;li&gt;Ability to work some weekends as needed (days off can be swapped for weekdays&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Skills&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Prior experience with cloning via Gibson assembly or Golden Gate protocols (library cloning experience is a plus)&lt;/li&gt;
&lt;li&gt;Knowledge of and experience with NGS library preparation, particularly single-cell and spatial workflows&lt;/li&gt;
&lt;li&gt;Computational skills (Python or R)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary for this position is $75,900. This amount does not include benefits or other forms of compensation.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The &lt;a href=&quot;https://evodesign.org/&quot;&gt;Hie Lab&lt;/a&gt; and &lt;a href=&quot;https://arcinstitute.org/labs/pluvinagelab&quot;&gt;Pluvinage Lab&lt;/a&gt; at the Arc Institute are seeking a joint Lab Manager to keep two fast-moving research groups running smoothly. The Pluvinage Lab studies the role of autoimmunity in neurodegeneration and brain aging, combining molecular biology, immunology, and functional genomics. The Hie Lab develops generative AI models for biology, designing proteins, genes, and genomes to counteract evolving threats and accomplish useful new functions. This is a largely operational role and the organizational backbone shared across both teams: you will manage ordering and inventory, organize reagents and protocols, and support data management so that scientists can focus on discovery. You will partner closely with researchers, vendors, and Arc’s operations and technology teams to continuously optimize how the labs run day to day.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are an organizational superstar who takes real satisfaction in bringing order to complexity and helping a team run smoothly and efficiently.&lt;/li&gt;
&lt;li&gt;You love to optimize processes—you naturally spot bottlenecks, streamline workflows, and put systems in place that make everyone around you more productive.&lt;/li&gt;
&lt;li&gt;You are proactive and service-oriented, actively looking for ways to support others before being asked.&lt;/li&gt;
&lt;li&gt;You are reliable and detail-oriented, the kind of person teammates trust to keep track of the things that matter.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced, collaborative research environment and enjoy working at the interface of people, science, and logistics.&lt;/li&gt;
&lt;li&gt;You are excited to support both hands-on wet-lab science and computational, data-driven research.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Manage purchasing and ordering across both labs: place orders, track shipments, process invoices, and serve as the main point of contact with vendors and Arc procurement.&lt;/li&gt;
&lt;li&gt;Own lab inventory by receiving, labeling, and stocking reagents and consumables, tracking stock levels, and setting up reorder systems so the labs never run out of critical materials.&lt;/li&gt;
&lt;li&gt;Organize and maintain shared reagents, equipment, and physical lab spaces, including freezers, chemical and sample storage, and common areas.&lt;/li&gt;
&lt;li&gt;Maintain and standardize protocols, SOPs, and lab documentation, keeping them organized, version-controlled, and easy for the team to find and follow.&lt;/li&gt;
&lt;li&gt;Support data management and organization, helping maintain shared drives, electronic lab notebooks, sample and metadata tracking, and consistent file and naming conventions across experimental and computational work.&lt;/li&gt;
&lt;li&gt;Serve as the main point of contact for institutional EH&amp;amp;S and SciOps and as a liaison between the labs and the greater Arc ecosystem.&lt;/li&gt;
&lt;li&gt;Coordinate lab logistics and operations, including onboarding new members, scheduling shared equipment, arranging maintenance and service, and supporting compliance with safety and institutional requirements.&lt;/li&gt;
&lt;li&gt;Continuously identify and implement process improvements that help both labs run more efficiently.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A Bachelor’s degree or higher (Bachelor’s, Master’s, PhD, or equivalent professional research experience) in a life sciences or related field&lt;/li&gt;
&lt;li&gt;5+ years of experience as a lab manager, research associate, or in research operations&lt;/li&gt;
&lt;li&gt;Exceptional organizational skills and attention to detail, with a proven ability to manage multiple priorities and keep complex operations on track.&lt;/li&gt;
&lt;li&gt;A proactive, service-oriented mindset and genuine enthusiasm for helping teams work efficiently.&lt;/li&gt;
&lt;li&gt;Strong communication and interpersonal skills, with the ability to coordinate across scientists, vendors, and institutional teams.&lt;/li&gt;
&lt;li&gt;Comfort with digital tools for organization and data management (e.g., spreadsheets, shared drives, inventory or lab-management software).&lt;/li&gt;
&lt;li&gt;Ability to work independently, take ownership of responsibilities, and follow through reliably in a fast-paced research environment.&lt;/li&gt;
&lt;li&gt;Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Basic molecular biology experience.&lt;/li&gt;
&lt;li&gt;Basic mammalian cell culture experience.&lt;/li&gt;
&lt;li&gt;Familiarity with electronic lab notebooks (e.g., Benchling) and/or inventory management systems.&lt;/li&gt;
&lt;li&gt;Experience with ordering and procurement systems and managing vendor relationships.&lt;/li&gt;
&lt;li&gt;Comfort supporting data organization for computational research (e.g., file management, basic command line, cloud storage).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $104,500 to $128,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Lab Operations Assistant to join the Scientific Operations team at Arc for an initial period of 6 months, with the opportunity to convert to a full-time employee role based on our assessment at the end of that period of our continued business needs and your performance.&lt;/p&gt;
&lt;p&gt;The Lab Operations Assistant is dedicated to providing exceptional support to Arc’s research labs. Responsibilities include media preparation and media QC, ordering and restocking consumables and other laboratory materials, glassware preparation, and other ad hoc tasks. This is primarily a manual labor role; the majority of your time will be spent on hands-on, physical tasks. Comfort with and commitment to physical work is essential.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are a self-starter with strategic vision, a hands-on approach, and a strong belief in safe lab practices&lt;/li&gt;
&lt;li&gt;You anticipate needs and deliver results independently with minimal supervision&lt;/li&gt;
&lt;li&gt;You are able to evaluate and triage competing priorities in order to maintain a nimble, effective approach to daily operations&lt;/li&gt;
&lt;li&gt;You have a passion for problem solving&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You have a deep understanding of customer service and a customer-first mindset&lt;/li&gt;
&lt;li&gt;You are highly dependable, with a strong sense of responsibility and commitment to your work.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform media preparation and media QC&lt;/li&gt;
&lt;li&gt;Order and restock consumables and other laboratory materials&lt;/li&gt;
&lt;li&gt;Clean, sterilize, prepare, and distribute glassware, ensuring appropriate levels of glassware inventory in all areas of operations&lt;/li&gt;
&lt;li&gt;Assist with management of launderable lab coats, scrubs, and towels&lt;/li&gt;
&lt;li&gt;Assist with basic equipment maintenance, moving, and installation&lt;/li&gt;
&lt;li&gt;Assist with gas management, including CO2, LN2, and dry ice&lt;/li&gt;
&lt;li&gt;Serve as a backup for shipping/receiving and chemical inventory management&lt;/li&gt;
&lt;li&gt;Adhere to safety guidelines and procedures, ensuring safety is the highest priority&lt;/li&gt;
&lt;li&gt;Demonstrate clear, concise and effective communication with lab members and team to ensure a high level of service.&lt;/li&gt;
&lt;li&gt;Work with the Lab Operations Manager and Lead to prioritize tasks and assignments, providing recommendations to maximize efficiency and productivity&lt;/li&gt;
&lt;li&gt;Independently handle operational processes or projects and proactively identify opportunities for improvement&lt;/li&gt;
&lt;li&gt;Participate in process improvement initiatives&lt;/li&gt;
&lt;li&gt;Author or revise Internal Procedures or Standard Operating Procedures as applicable&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;0-1 years prior laboratory operations experience&lt;/li&gt;
&lt;li&gt;Minimum education level: BS degree in biological sciences&lt;/li&gt;
&lt;li&gt;Must be able to multi-task and prioritize tasks&lt;/li&gt;
&lt;li&gt;Must have the ability to lift 50 pounds and occasionally move heavy equipment&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Should possess strong attention to detail with critical analytical skills&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Should be resourceful and possess good organization skills&lt;/li&gt;
&lt;li&gt;Should possess the ability to independently solve problems and troubleshoot while performing work&lt;/li&gt;
&lt;li&gt;Must be proactive and able to self-initiate&lt;/li&gt;
&lt;li&gt;Should possess effective communication skills&lt;/li&gt;
&lt;li&gt;Should demonstrate proficiency with Microsoft Office Suite and other general use software applications&lt;/li&gt;
&lt;li&gt;Prolonged periods standing and walking throughout facilities&lt;/li&gt;
&lt;li&gt;Must be able to bend, lift, stretch, and climb at times&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The hourly rate range for this position is $25 - $31 per hour. These amounts reflect the range that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;This role is responsible for leading our People Operations team and partnering with the Head of People and People Partner team to deliver our Compensation program.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;You are an experienced HR operator that’s excited to uplevel People Operations using AI. You believe a great user experience is built on great tech. You love to solve problems as part of a team and see the best in people.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;Lead our People Operations team:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Drive AI-native operations across the People function by implementing technology driven solutions with a great employee experience&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Oversee the core work of the People Ops team (onboarding, offboarding, processing employee changes, etc.)&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Serve as escalation point for complex operational issues, benefits decisions, and compensation situations&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Manage the relationship with our PEO to deliver our benefits program and ensure compliance throughout our operations&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Lead our benefits strategy, ensuring our benefits package is competitive and supports our team&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Establish and lead a culture of service and operational excellence&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;Lead the delivery of our compensation program:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Lead the delivery of Arc&#39;s compensation program, including owning cyclical compensation events&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Use AI-driven workflows to develop and maintain compensation benchmarking and Arc’s structure&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Partner with hiring managers and recruiting on offers, including building AI driven tools to uplevel process and information sharing&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;8+ years of experience in People Operations (or other relevant experience)&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Experience supporting benefits and compensation programs&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Proven track record of implementing AI and automation&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Strong operational background and cross functional collaborator&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Great manager&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Wide range of experience in technology and workplace tools&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Hybrid role, onsite 3 days per week&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;The base salary range for this position is $147,500 - $181,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/hsulab&quot;&gt;The Hsu Lab&lt;/a&gt; is looking for postdoctoral researchers, who are curious, creative and ambitious and share our vision of programming biology and building tangible products that impact everyday lives in the real world. Broadly, we develop technologies for biological engineering and design. Recent work has included bridge recombinases, large serine recombinases, CRISPR systems, and AI-designed molecular systems. Beyond the genome, we aim to modulate physiology through synthetic peptides, microbiome engineering, or rational nutrition. Finally, we merge advances in biology and AI to mine the metagenomic sequence space, enable generative genome design, and build towards a virtual cell.&lt;/p&gt;
&lt;p&gt;Lately, we have been thinking about the following research frontiers (your innovative ideas could be related, or broadly fit into our thematic interests):&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Discovery and engineering of modulators/probes/drug-like molecules for general physiological control and human enhancement (e.g. sleep, appetite, energy etc) by employing in silico, in vitro and/or in vivo approaches&lt;/li&gt;
&lt;li&gt;Immune rejuvenation and skin/microbe/barrier tissue rejuvenation for aging-related phenotypes&lt;/li&gt;
&lt;li&gt;New programmable molecular tools for synthetic biology and AI-guided perturbations of cellular behavior&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Postdocs in the lab are encouraged to lead ambitious, independent projects, resulting in high-impact publications. You will have the opportunity to collaborate widely across Arc, Stanford, and the broader Bay Area ecosystem, with access to strong platforms in our lab and our institutions for genomics, single-cell technologies, synthetic biology, computation, and experimental model systems.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Extremely Curious &amp;amp; Self-Motivated:&lt;/strong&gt; You push the boundaries of biotechnology and/or biomedical research.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;High-Velocity Researcher:&lt;/strong&gt; You thrive in a fast-paced environment and have a bias for action, conducting rigorous and impactful research at scale.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Intellectually Independent:&lt;/strong&gt; You are a &quot;first-principles&quot; thinker, able to design new research directions and projects.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technical Polyglot:&lt;/strong&gt; You are comfortable (or eager to become so) at the intersection of wet-lab experimentation and computational modeling.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct high-impact research:&lt;/strong&gt; Design, execute, and analyze experiments; take end-to-end ownership of a research project within the lab’s scientific focus, with guidance from the PI and increasing independence as you develop expertise.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a future scientific leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present at national and international conferences, and build a network of collaborators across Arc, Stanford, and beyond.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster scientific excellence: &lt;/strong&gt;Mentor and train research associates, technicians, and students; engage in Arc-wide activities (seminars, symposia); contribute to a collaborative research environment; maintain rigorous experimental records and documentation; and contribute to lab operations including protocol development and maintaining shared infrastructure.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (MD, PhD, or equivalent) in a relevant life sciences or engineering field.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;li&gt;Track record of creative, high-impact research as demonstrated by publications, patents, developed tools, software etc.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/hornslab&quot; target=&quot;_blank&quot;&gt;The Horns Lab&lt;/a&gt; is seeking motivated, hard-working, and curious scientists. Our lab develops and applies technologies that bridge synthetic biology and genomics to answer fundamental and translational questions in human health, with a particular emphasis on immunology and neuroscience. We build new tools and use them to discover mechanisms in complex, dynamic systems, including the immune system, the brain, and other tissues.&lt;/p&gt;
&lt;p&gt;Postdocs in the lab are encouraged to lead ambitious, independent projects, resulting in high-impact publications, and to prepare for long-term careers in academia or industry. You will have the opportunity to collaborate widely across Arc, Stanford, and the broader Bay Area ecosystem, with access to strong platforms in our lab and our institutions for genomics, single-cell technologies, synthetic biology, computation, and experimental model systems.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;The questions we ask:&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;We are interested in how cells change over time and how those dynamics drive health and disease, and in building technologies to measure and control those dynamics. Example questions include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;How can we measure cellular dynamics non-destructively at scale, capturing histories, interactions, and functional outputs?&lt;/li&gt;
&lt;li&gt;How do extracellular vesicles (EVs) and virus-like particles (VLPs) interact with cells and tissues, and what molecular rules govern secretion, trafficking, uptake, and cargo delivery?&lt;/li&gt;
&lt;li&gt;How can we engineer delivery systems to target specific cell types and achieve efficient cytosolic delivery with minimal off-target effects?&lt;/li&gt;
&lt;li&gt;How do immune cells change state, migrate, and interact with tissues over time during homeostasis, inflammation, and disease?&lt;/li&gt;
&lt;li&gt;How can we profile immune receptor specificity and function at scale (TCRs/BCRs) to decipher immune recognition and control immune behaviors?&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;em&gt;The approaches we take:&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;We combine synthetic biology, genomics, cellular and mammalian models, and computation. Depending on the project, approaches may include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Mammalian synthetic biology&lt;/li&gt;
&lt;li&gt;Single-cell and spatial multi-omics&lt;/li&gt;
&lt;li&gt;Engineering and mechanistic study of EVs, VLPs, and other delivery systems&lt;/li&gt;
&lt;li&gt;Immune cell engineering and functional assays&lt;/li&gt;
&lt;li&gt;Sequencing-based measurement technologies&lt;/li&gt;
&lt;li&gt;Computational analysis and modeling of high-dimensional datasets&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are extremely curious and self-motivated.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and enjoy proposing and driving new research directions (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adopt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited to solve puzzles that have translational impact and/or enable new discovery and therapeutic approaches.&lt;/li&gt;
&lt;li&gt;You have a strong foundation in synthetic biology or genomics technology development, and/or in immunology or neuroscience.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct high-impact research: &lt;/strong&gt;Design, execute, and analyze experiments; take end-to-end ownership of a research project within the lab’s scientific focus, with guidance from the PI and increasing independence as you develop expertise.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a future scientific leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present at national and international conferences, and build a network of collaborators across Arc, Stanford, and beyond.\&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster scientific excellence: &lt;/strong&gt;Mentor and train research associates, technicians, and students; engage in Arc-wide activities (seminars, symposia); contribute to a collaborative research environment; maintain rigorous experimental records and documentation; and contribute to lab operations including protocol development and maintaining shared infrastructure.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (PhD, MD, MD/PhD, DVM, or equivalent) in bioengineering, synthetic biology, genomics, immunology, neuroscience, molecular biology, or a related field.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills, including a track record of scientific writing (manuscripts, preprints, or equivalent).&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Our research group thrives on bringing together people with diverse expertise. The best fit is typically someone strong in at least one area and excited to learn the others. Experience in one or more of the following is a plus:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Single-cell sequencing and analysis (scRNA-seq, scATAC-seq, CITE-seq)&lt;/li&gt;
&lt;li&gt;Spatial transcriptomics and multi-omics&lt;/li&gt;
&lt;li&gt;Pooled perturbation screens (CRISPRi/a/KO, Perturb-seq)&lt;/li&gt;
&lt;li&gt;Building new sequencing-based assays or new measurement modalities&lt;/li&gt;
&lt;li&gt;Molecular engineering (e.g. protein design and engineering)&lt;/li&gt;
&lt;li&gt;Mammalian synthetic biology (e.g. genetic circuit design)&lt;/li&gt;
&lt;li&gt;High-throughput library design and screening in mammalian cells&lt;/li&gt;
&lt;li&gt;Immune cell biology or engineering&lt;/li&gt;
&lt;li&gt;Immune receptor biology and profiling&lt;/li&gt;
&lt;li&gt;Neurobiology&lt;/li&gt;
&lt;li&gt;EVs, VLPs, or related nanoparticle systems&lt;/li&gt;
&lt;li&gt;In vivo models (e.g. mouse)&lt;/li&gt;
&lt;li&gt;Expertise in analysis of high-dimensional datasets (e.g. single-cell transcriptomics, spatial transcriptomics, pooled screening, using Python or R)&lt;/li&gt;
&lt;li&gt;Strong quantitative mindset&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;How to Apply&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Please submit:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;CV&lt;/li&gt;
&lt;li&gt;Brief cover letter describing your research interests, what kinds of projects you’re excited to lead, and why the Horns Lab is a fit. Please be sure to include contact information for 3+ references.&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://urldefense.proofpoint.com/v2/url?u=https-3A__ishajainlab.com_&amp;amp;d=DwMF-g&amp;amp;c=iORugZls2LlYyCAZRB3XLg&amp;amp;r=vNfva3Zcxin30zKAYt_noLb6dTqLO9YBIU9maXLKVgc&amp;amp;m=b7Q1OMvGii23FwRK-OoLUQBCXtY-Iv2b3lg6TRHv7n0&amp;amp;s=4LclCVUYC_syLsZYmGpVfdJTbpdN6zNlyn-sI3wu3Vk&amp;amp;e=&quot; target=&quot;_blank&quot;&gt;The Jain Lab&lt;/a&gt; is looking for motivated, hard-working and curious applicants. At a high level, we study how organisms interact with their environments – how “what we breathe” and “what we eat” affects our metabolism and disease progression. More specifically, we are focused on oxygen and vitamin/cofactor metabolism. We recently discovered that chronic hypoxia (equivalent to living in the mountains of Peru or Nepal) can serve as a therapy for mitochondrial disease. This approach is currently in clinical trials. This work has inspired a broader set of research directions ranging from fundamental biochemistry to animal physiology.&lt;/p&gt;
&lt;p&gt;The questions we ask:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;How do cells and organisms sense oxygen or vitamin levels? Are there novel oxygen sensors and vitamin sensors to be found?&lt;/li&gt;
&lt;li&gt;How does the body adapt to variations in oxygen levels? Or vitamin levels?&lt;/li&gt;
&lt;li&gt;When the supply and demand of oxygen or vitamins becomes mismatched, how does this contribute to disease?&lt;/li&gt;
&lt;li&gt;Can we “turn the oxygen and vitamin dials” as creative new therapies?&lt;/li&gt;
&lt;li&gt;What is the most practical form of turning these concepts into translatable therapies?&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The approach we take: CRISPR screens, metabolomics, classical biochemistry/molecular biology, animal physiology and beyond.&lt;/p&gt;
&lt;p&gt;Post-docs will be encouraged to lead independent projects resulting in high impact publications, present at conferences and prepare for long-term careers in academia or industry.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are extremely curious and self-motivated to push the boundaries of biomedical research.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adapt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited by solving puzzles that have a translational impact.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Find new functions for enzymes or cofactors (vitamins)&lt;/li&gt;
&lt;li&gt;Contribute to our molecular understanding of how key metabolites are sensed by the body.&lt;/li&gt;
&lt;li&gt;Develop novel therapeutic strategies for nutrient-based therapies.&lt;/li&gt;
&lt;li&gt;Collaborate with post-docs and students to understand how enzymes and metabolites interact for key biochemical functions.&lt;/li&gt;
&lt;li&gt;Publish, present, and represent that lab in journals and conferences.&lt;/li&gt;
&lt;li&gt;Present at lab meetings, and participate in Arc-wide activities (seminars, symposiums, etc).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in metabolism, animal physiology, molecular biology, biochemistry, genomics, or related field&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/hsulab&quot;&gt;The Hsu Lab&lt;/a&gt; is looking for postdoctoral researchers, who are curious, creative and motivated to advance the state-of-the-art in generative AI applied to biology, including Arc’s frontier biological foundation models (Evo, Evo 2, State, Stack, Bioreason, and beyond). The successful candidate is passionate about developing ML models for biological understanding and design, leveraging frontier approaches such as novel ML architectures, post-training, agentic reasoning, and more. Current areas of interest of the lab include building predictive models of life (e.g. by integrating Evo and State), AI agents and systems, genome mining, and invention of new therapeutics through AI-guided approaches.&lt;/p&gt;
&lt;p&gt;Postdocs in the lab are encouraged to lead ambitious, independent projects, resulting in high-impact publications. You will have the opportunity to collaborate widely across Arc, Stanford, and the broader Bay Area ecosystem, with access to strong platforms in our lab and our institutions for genomics, single-cell technologies, synthetic biology, high-performance computing clusters, and experimental model systems.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Extremely Curious &amp;amp; Self-Motivated:&lt;/strong&gt; You push the boundaries of machine learning, biotechnology, and/or biomedical research.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;High-Velocity Researcher:&lt;/strong&gt; You thrive in a fast-paced environment and have a bias for action, conducting rigorous and impactful research at scale.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Intellectually Independent:&lt;/strong&gt; You are a &quot;first-principles&quot; thinker, able to design new research directions and projects.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technical Polyglot:&lt;/strong&gt; You are comfortable (or eager to become so) at the intersection of ML and computational biology, and eager to collaborate with wet-lab scientists.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Puzzle Solver: &lt;/strong&gt;You are excited by solving puzzles that have a translational impact and/or creating new therapeutic approaches.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct high-impact research:&lt;/strong&gt; Design, execute, and analyze computational experiments; take end-to-end ownership of a research project within the lab’s scientific focus, with guidance from the PI and increasing independence as you develop expertise.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a future scientific leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present at national and international conferences, and build a network of collaborators across Arc, Stanford, and beyond.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster scientific excellence:&lt;/strong&gt; Mentor and train research associates, technicians, and students; engage in Arc-wide activities (seminars, symposia); contribute to a collaborative research environment; maintain rigorous coding standards and documentation; and contribute to lab operations including software development and maintaining shared infrastructure.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Computer Science, Bioinformatics, Computational Biology, Genetics/Genomics&lt;/li&gt;
&lt;li&gt;Expertise with Python, bash, and standard deep learning frameworks such as PyTorch.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;li&gt;Track record of creative, high-impact research as demonstrated by publications, patents, developed tools, software etc.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Postdoc to join the &lt;a href=&quot;https://arcinstitute.org/labs/pluvinagelab&quot; target=&quot;_blank&quot;&gt;Pluvinage Lab&lt;/a&gt; at the Arc Institute. Our goal is to improve the lives of patients with neurological diseases. We do this by exploring undiagnosed autoimmunity in rare mystery cases and common neurodegenerative conditions alike. Starting with clinical observations and primary patient tissue, we use functional genomics, protein display technologies, and computational tools to embark on deep mechanistic dives into the contribution of autoimmunity to cognitive function. Your work will have the potential to uncover novel autoantibodies that drive cognitive decline in autoimmune encephalitis, that modulate cognitive decline in dementia, and that promote cognitive resilience in healthy brain aging.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;The questions we ask:&lt;/em&gt;&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;How do autoantibodies regulate cognition?&lt;/li&gt;
&lt;li&gt;What is the source, target, and mechanism of pathogenic autoantibodies in neurological disease?&lt;/li&gt;
&lt;li&gt;How can we eliminate pathogenic autoantibodies while leaving the rest of the immune system intact?&lt;/li&gt;
&lt;li&gt;How does comorbid autoimmunity contribute to cognitive decline in neurodegeneration?&lt;/li&gt;
&lt;li&gt;Are there protective autoantibodies that promote cognitive resilience in healthy brain aging?&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;em&gt;The approaches we take:&lt;/em&gt; discovery-driven projects starting with human samples (cerebrospinal fluid, PBMCs, brain tissue) from curated cohorts of patients with neurological diseases, CRISPR screens, phage display, immune repertoire sequencing&lt;/p&gt;
&lt;p&gt;Postdocs will be encouraged to lead independent projects resulting in high impact publications, present at conferences, and prepare for long-term careers in academia or industry. Clinical residents or fellows interested in physician-scientist pathways are encouraged to apply.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You have a strong foundation in human immunology, neurobiology, and/or computational biology and are eager to apply this expertise to translational questions in neurological disease.&lt;/li&gt;
&lt;li&gt;You are extremely curious and self-motivated.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adopt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited by solving puzzles that have a translational impact and/or creating new therapeutic approaches.&lt;/li&gt;
&lt;li&gt;You love to collaborate and explore outside your field of expertise.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct High-Impact Research: &lt;/strong&gt;Design, execute, and analyze experiments, taking ownership of a research project within the lab&#39;s scientific focus, with guidance from the PI and increasing independence as you develop expertise&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a Future Scientific Leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present your work at national and international conferences, and build a network of collaborators across the Arc Institute and beyond&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster Scientific Excellence: &lt;/strong&gt;Mentor and train research associates, technicians, and students, engage in Arc-wide activities (seminars, symposia, journal clubs); contribute to a collaborative, inclusive research environment; keep rigorous experimental records and documentation; contribute to lab operations, including equipment maintenance and protocol development&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (MD, PhD, MD/PhD, or equivalent) in immunology, neuroimmunology, neuroscience, genetics, or a related field&lt;/li&gt;
&lt;li&gt;Demonstrated expertise in human immunology, neurobiology, or computational biology with a strong understanding of immune–nervous system interactions&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;How to Apply&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Please submit:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;CV&lt;/li&gt;
&lt;li&gt;Brief cover letter describing your research interests, what kinds of projects you’re excited to lead, and why the Pluvinage Lab is a fit. Please be sure to include contact information for 3+ references.&lt;/li&gt;
&lt;/ol&gt;
&lt;div&gt;
&lt;div class=&quot;job__description body&quot;&gt;
&lt;div&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The &lt;a href=&quot;https://arcinstitute.org/labs/zhoulab&quot;&gt;Zhou Lab&lt;/a&gt; is looking for motivated, hard-working and curious applicants. Our expertise is in single-cell epigenomic modeling. We use high-throughput single-cell multiomic technologies and build computational models to study spatiotemporal dynamics of gene regulation.&lt;/p&gt;
&lt;p&gt;The successful candidate will play a crucial role in advancing the state-of-the-art in generative AI applied to biology, including DNA sequence, gene regulation, and perturbation modeling. You will focus on developing ML models for biological data, leveraging frontier approaches such as novel ML architectures, interpretability techniques, and more. You will also apply your models for important computational biology applications in genome mining, molecular technology development, and invention of new therapeutic approaches.&lt;/p&gt;
&lt;p&gt;This role is a unique opportunity to advance state-of-the-art machine learning in genomics and cell biology, contribute to high-impact scientific discoveries, and help define how computational approaches shape our understanding and engineering of biology. You will work in a highly collaborative team with expert experimental biologists to realize the full impact of your work, and also have the opportunity to contribute to Institute-wide machine learning efforts such as Arc’s Virtual Cell Initiative.&lt;/p&gt;
&lt;p&gt;Post-docs will be encouraged to lead independent projects resulting in high impact publications, present at conferences and prepare for long-term careers in academia or industry.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about developing machine learning models with real-world applications and scientific impact.&lt;/li&gt;
&lt;li&gt;You have a strong understanding of modern deep learning, computational biology, and genetics.&lt;/li&gt;
&lt;li&gt;You are known for your ability to analyze/visualize complex datasets, build high-quality ML tools, draw meaningful conclusions, and work effectively in a multidisciplinary team.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are eager to learn and adapt new techniques.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects with input from your PI.&lt;/li&gt;
&lt;li&gt;You are excited about collaborating with a multidisciplinary team of experimental biologists and machine learning researchers at Arc.&lt;/li&gt;
&lt;li&gt;You are familiar with recently reported projects in the fields of AI for genomics and biological design, including DNA sequence to function models, genome language models, and single-cell foundation models.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Train and evaluate state-of-the-art machine learning models for genomics&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Design, perform, and analyze experiments for model applications&lt;/li&gt;
&lt;li&gt;Keep appropriate experimental records and documentation&lt;/li&gt;
&lt;li&gt;Analyze results with the Principal Investigator&lt;/li&gt;
&lt;li&gt;Collaborate with postdocs, students, and employees on model development and data analyses&lt;/li&gt;
&lt;li&gt;May mentor/train research associates, technicians, and students.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Publish, present, and represent the Zhou lab in journals and conferences.&lt;/li&gt;
&lt;li&gt;Present at lab meetings, and participate in Arc-wide activities (seminars, science socials, symposiums, etc).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (MD, PhD) in Computer Science, Machine Learning, Computational Biology, Bioinformatics, Genetics/Genomics.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;How to Apply&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Please submit:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;CV&lt;/li&gt;
&lt;li&gt;Brief cover letter describing your research interests, what kinds of projects you’re excited to lead, and why the Zhou Lab is a fit. Please be sure to include contact information for 3+ references.&lt;/li&gt;
&lt;/ol&gt;
&lt;div&gt;
&lt;div class=&quot;job__description body&quot;&gt;
&lt;div&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Research Associate II to join the Horns laboratory at the Arc Institute. In this position, you will contribute to developing the next generation of platform technologies for monitoring and manipulating cells in living animals, and gain expertise in molecular biology, cell engineering, viral vector production, and in vivo models. You will have the opportunity to work with world-leading scientists in relevant fields, including single-cell genomics, computational biology, and molecular engineering.&lt;/p&gt;
&lt;p&gt;This position offers a unique chance for a highly motivated and curious researcher to work on cutting-edge molecular technologies at the intersection of synthetic biology and genomics. Some of the relevant projects extend from our recent work in developing and using &lt;a href=&quot;https://doi.org/10.1016/j.cell.2023.06.013&quot;&gt;cellular RNA exporters to non-destructively monitor cell dynamics and deliver mRNA between cells&lt;/a&gt;. You will help take this system into living animals, engineering systems that report the transcriptome of specific cell populations from a blood draw and enable tracking of how tissues respond to perturbations.&lt;/p&gt;
&lt;p&gt;This is a great stepping stone for candidates looking to enroll in a PhD program in the future, as you will be involved in designing projects from the ground up and co-authoring papers. The ideal candidate must have a strong background in molecular biology and mammalian cell culture, and will learn to apply their skills to building novel molecular technologies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You can work fast and are detail-oriented. You are careful, meticulous, and diligent about good documentation practices, good lab practices, and keeping things organized while moving at a rapid pace.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to participate and to offer help.&lt;/li&gt;
&lt;li&gt;You are a problem solver. Building new technologies comes with issues you need to troubleshoot. You pride yourself in your ability to troubleshoot complex problems.&lt;/li&gt;
&lt;li&gt;You are comfortable working with animals. Mouse work is central to this role and you perform it with care, rigor, and adherence to approved protocols.&lt;/li&gt;
&lt;li&gt;You explicitly wish to use this experience to gain entry into a PhD program and are able to provide a minimum 2-year commitment to build a portfolio of work to support you in that endeavor.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Utilize a wide array of molecular biology techniques, such as restriction cloning, Gibson assembly, DNA/RNA isolation, cDNA synthesis, PCR, qPCR, NGS library preparation, and more.&lt;/li&gt;
&lt;li&gt;Perform in vivo experiments in mice, including vector administration, longitudinal monitoring, and collection and processing of blood and tissue samples.&lt;/li&gt;
&lt;li&gt;Produce and characterize viral vectors for in vivo delivery.&lt;/li&gt;
&lt;li&gt;Conduct tissue culture and transfection-based experiments, including microscopy and flow cytometry readouts.&lt;/li&gt;
&lt;li&gt;Independently carry out cell culture and in vivo experiments and molecular biology assays.&lt;/li&gt;
&lt;li&gt;Assist with research planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team. This is an excellent opportunity for candidates before enrolling in a PhD program, as you will be involved in all stages of a project under the guidance of an experienced scientist.&lt;/li&gt;
&lt;li&gt;Analyze and present data at internal subgroup meetings and seminars.&lt;/li&gt;
&lt;li&gt;Maintain an organized and detailed lab notebook.&lt;/li&gt;
&lt;li&gt;Assist with organizing and managing laboratory resources, including ordering supplies, managing inventory, and maintaining equipment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS or equivalent professional experience in cell &amp;amp; molecular biology, biochemistry, bioengineering, or similar field.&lt;/li&gt;
&lt;li&gt;2+ years of relevant experience in an academic or industry setting (including independent lab work during your undergraduate studies).&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience with standard molecular biology techniques, such as cloning, PCR, qPCR, or plasmid preparation.&lt;/li&gt;
&lt;li&gt;Hands-on experience with rodent work, including handling and procedures.&lt;/li&gt;
&lt;li&gt;Proficiency with mammalian cell culture and transfections.&lt;/li&gt;
&lt;li&gt;Strong critical thinking and problem-solving skills.&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills.&lt;/li&gt;
&lt;li&gt;Highly motivated, curious, and a team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;NGS library preparation.&lt;/li&gt;
&lt;li&gt;AAV production, purification, and titering.&lt;/li&gt;
&lt;li&gt;Experience with mouse disease models.&lt;/li&gt;
&lt;li&gt;Ability to analyze large and complex data sets using Python, R, or similar tools.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;How to Apply&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Please submit:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;CV&lt;/li&gt;
&lt;li&gt;Brief cover letter describing your research interests, what kinds of projects you’re excited to lead, and why the Horns Lab is a fit. Please be sure to include contact information for 3+ references.&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The base salary for this position is $75,900. This amount does not include benefits or other forms of compensation.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;This is a Research Associate II position in the &lt;a href=&quot;https://arcinstitute.org/labs/konermannlab&quot;&gt;Konermann Lab at Arc Institute&lt;/a&gt; and the Stanford Medical School Department of Biochemistry, working closely with a scientist in the lab to identify the key pathways that drive the progression of neurodegenerative diseases using advanced CRISPR technologies and functional assays.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are curious and eager to learn about unsolved questions in biological medicine.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You love to tackle difficult biological problems that are critical to advancing mechanistic understanding and therapeutics for neurodegeneration.&lt;/li&gt;
&lt;li&gt;Perseverance and critical thinking are your strengths in testing hypotheses and designing experiments&lt;/li&gt;
&lt;li&gt;You are detail-oriented. You are careful and diligent about good documentation practices and good lab practices.&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort and you pride yourself in taking the initiative to help out.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;In this position, you will:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform molecular and cellular experiments including mammalian cell culture, transfection, Western blot, RT-qPCR, and immunostaining.&lt;/li&gt;
&lt;li&gt;Perform imaging-based screening at the organelle level (particularly, lysosome and lipid droplet)&lt;/li&gt;
&lt;li&gt;Perform lipid-based assay including lipid extraction and lipidomics&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Collaborate closely with a scientist in the laboratory to conduct large-scale screening of genetic modifiers of neurological diseases such as Alzheimer’s disease using stem cell-derived brain models.&lt;/li&gt;
&lt;li&gt;Learn various cutting-edge techniques while participating in a project at the intersection of neuroscience, stem cell biology, and genomics.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Learn to conduct experimental planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team. This is a good opportunity for candidates before enrolling in a PhD program as you will be involved in all stages of a project under the guidance of an experienced scientist.&lt;/li&gt;
&lt;li&gt;You will also have a broad range of experience in collaboration with a cross-functional team to develop your expertise in biomedical research to build your career in the R&amp;amp;D sector of the industry if you are interested in that career path.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS or equivalent professional experience in cellular biology, neuroscience, immunology, or another relevant field&amp;nbsp;&lt;/li&gt;
&lt;li&gt;2+ years of relevant experience (including independent lab work during your undergraduate studies) incorporating strong hands-on experience with cell culture techniques and cell-based assays.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Strong critical thinking and problem-solving skills&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills&lt;/li&gt;
&lt;li&gt;You’re both a strong individual contributor as well as a collaborative team member.&lt;/li&gt;
&lt;li&gt;You’re eager to collaborate with a cross-functional team at Arc spanning the Konermann lab, the Multi-Omics Tech Center, and the Cellular Model Team.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Skills&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience working with human ESC/iPSCs and neural and/or immune cell types is a plus for this position&lt;/li&gt;
&lt;li&gt;Experience with computational analysis for multiomics is a plus for this position&lt;/li&gt;
&lt;li&gt;Experience with molecular biology such as protein purification and immunoprecipitation is a plus for this position&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary for this position is $75,900. This amount does not include benefits or other forms of compensation.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Scientific Program Manager Lead to drive and coordinate strategic research initiatives across Arc Institute. This role will be instrumental in orchestrating complex, multi-disciplinary projects that span our Technology Centers encompassing cellular models, mammalian models, genome engineering, multi-omics, computational biology, and machine learning.&lt;/p&gt;
&lt;p&gt;A defining dimension of this role is the facilitation of cross-functional and cross-institutional collaboration to keep Arc&#39;s most complex programs moving. You will lead regular working meetings across Technology Centers, Core Investigator groups, and institute leadership—surfacing and resolving blockers, ensuring effective resource allocation, and maintaining alignment across teams working toward shared scientific goals. As Arc&#39;s research programs grow in scope and ambition, this coordination function becomes increasingly critical to execution.&lt;/p&gt;
&lt;p&gt;The ideal candidate combines deep technical knowledge of biological research with strong program management skills and a track record of driving progress across distributed, interdisciplinary teams. In this role, you will work closely with Technology Center leaders, Core Investigators, and institute leadership to advance Arc&#39;s Virtual Cell and Alzheimer&#39;s Disease initiatives through structured, proactive program oversight.&lt;/p&gt;
&lt;p&gt;In this role, you will also shape the strategic direction of Arc&#39;s research programs, mentor junior team members, and establish program management frameworks that appropriately support the institute&#39;s scale.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You’re a strategic relationship builder. You understand that scientific progress at the institutional level depends on strong internal and external partnerships. You have deep experience cultivating and managing alliances with academic partners, industry collaborators, and peer institutions—and you know how to structure these relationships so they deliver value for all parties over the long term.&lt;/li&gt;
&lt;li&gt;You love structuring problems and solutions. You take a strategic view and excel at breaking down complex research initiatives into clear workstreams and deliverables, identifying dependencies, and anticipating potential bottlenecks before anyone else. You have a track record of successfully managing programs from inception to completion across multiple scientific disciplines and institutional boundaries.&lt;/li&gt;
&lt;li&gt;You’re able to find the razor’s edge between formality and chaos. You know that the path to the biggest discoveries are never linear. So you balance process formality with leaving space for innovation, always with an eye to delivering outstanding results. You’ve developed an intuition for when structure enables and when it constrains—especially in multi-institutional settings where flexibility and clarity must coexist.&lt;/li&gt;
&lt;li&gt;You are persuasive but tactful. You have a presence that commands respect (including from people more senior/knowledgeable than you) yet bring tact, diplomacy, and fun to your interactions with team members. You’ve built trust and influence across organizational and institutional boundaries throughout your career.&lt;/li&gt;
&lt;li&gt;You’re energized by learning. You’re a lifelong learner that loves to work at the intersection of biology and technology. You stay current with scientific developments and can connect emerging research trends to operational planning, partnership strategy, and program design.&lt;/li&gt;
&lt;li&gt;You lead through influence, not authority. You have extensive experience building consensus across diverse scientific groups—both internal and external—managing up effectively, and driving alignment without formal authority. You know how to navigate the unique dynamics of academic-industry hybrid environments and multi-institutional collaborations.&lt;/li&gt;
&lt;li&gt;You think institutionally. You don’t just manage projects—you see the bigger picture. You proactively identify opportunities to strengthen Arc’s collaborative network, and you champion scalable frameworks for partnership management that benefit research teams across the organization.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead and coordinate major research initiatives that span multiple Technology Centers and external collaborators, ensuring clear communication of objectives, timelines, and dependencies across institutional boundaries&lt;/li&gt;
&lt;li&gt;Manage Arc’s portfolio of internal and external scientific collaborations and strategic alliances&lt;/li&gt;
&lt;li&gt;Structure and negotiate collaboration frameworks, ensuring that partnership agreements, governance models, and joint milestones are clearly defined and aligned with Arc’s scientific mission&lt;/li&gt;
&lt;li&gt;Serve as a primary relationship manager for key partners, building trust, resolving issues, and ensuring that collaborations remain productive and mutually beneficial over time&lt;/li&gt;
&lt;li&gt;Facilitate regular cross-functional and cross-institutional meetings to drive progress, remove blockers, and ensure effective resource allocation&lt;/li&gt;
&lt;li&gt;Design and implement institute-wide program management frameworks, project tracking systems, and collaboration processes that scale with organizational growth and an expanding external network&lt;/li&gt;
&lt;li&gt;Identify opportunities for new strategic partnerships and collaborations that could accelerate Arc’s research programs, and present well-structured recommendations to institute leadership&lt;/li&gt;
&lt;li&gt;Track and communicate project and partnership progress to stakeholders at multiple levels, from technical teams to institute leadership and founders&lt;/li&gt;
&lt;li&gt;Serve as a strategic thought partner to Technology Center leaders and Core Investigators on program design, risk mitigation, resource planning, and external collaboration strategy&lt;/li&gt;
&lt;li&gt;Help foster a culture of innovation, excellence, collaboration, and continuous improvement&lt;/li&gt;
&lt;li&gt;Mentor and develop junior program management staff, building institutional capacity for program management&lt;/li&gt;
&lt;li&gt;Lead change management efforts as the institute scales, ensuring that evolving processes support rather than hinder scientific discovery and external engagement&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD degree in Life Sciences or a related field and 8–12 years of experience in program management in a research or translational setting&lt;/li&gt;
&lt;li&gt;Demonstrated experience managing external scientific collaborations, strategic alliances, or academic-industry partnerships, with a proven ability to structure, navigate, and steward productive long-term relationships&lt;/li&gt;
&lt;li&gt;Background in one or more relevant biology areas (genome engineering, multi-omics, cellular engineering, etc.)&lt;/li&gt;
&lt;li&gt;Strong track record of successfully managing complex, multi-stakeholder projects in research environments, balancing competing priorities while maintaining focus on key long-term strategic objectives&lt;/li&gt;
&lt;li&gt;Track record of building and scaling program management or alliance management functions in fast-growth research organizations&lt;/li&gt;
&lt;li&gt;Experience with advanced project management tools and methodologies (e.g., Asana, Jira, Smartsheet)&lt;/li&gt;
&lt;li&gt;Excellent communication skills and are comfortable regularly engaging with a broad range of research scientists, experimentalists, senior management, and external partners&lt;/li&gt;
&lt;li&gt;Demonstrated experience leading cross-functional and cross-institutional initiatives and building influence without direct authority in matrixed or research-intensive organizations&lt;/li&gt;
&lt;li&gt;Proven ability to manage and mentor team members, with a track record of developing talent in research operations&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with computational biology or machine learning projects&lt;/li&gt;
&lt;li&gt;Background in multiple biology domains&lt;/li&gt;
&lt;li&gt;Direct experience managing university-industry research partnerships or consortium-level scientific collaborations&lt;/li&gt;
&lt;li&gt;Familiarity with intellectual property, material transfer agreements, or other legal frameworks common in academic-industry collaborations&lt;/li&gt;
&lt;li&gt;Change management certification or experience leading organizational transformation initiatives&lt;/li&gt;
&lt;li&gt;Public speaking and scientific communication experience&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $187,500 - $237,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;span style=&quot;font-size: 12pt;&quot;&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/h3&gt;
&lt;p&gt;We are hiring for &lt;strong&gt;two Scientist positions&lt;/strong&gt; on Arc&#39;s Computational Technology Center, each turning large-scale perturbational and single-cell datasets into mechanistic biological insight:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;&lt;strong&gt;Perturb-seq / functional genomics track&lt;/strong&gt; — focused on large-scale CRISPR screen and Perturb-seq analysis, contributing to the &lt;strong&gt;Virtual Cell Initiative (VCI)&lt;/strong&gt;.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Neurobiology / microglia track&lt;/strong&gt; — focused on single-cell analysis of microglia and neurodegeneration, contributing to the &lt;strong&gt;Alzheimer&#39;s Disease Initiative (ADI)&lt;/strong&gt;.&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;Please indicate which focus area you&#39;re applying for in your application.&lt;/p&gt;
&lt;p&gt;Situated at the interface of functional genomics, computational biology, and machine learning, successful candidates will analyze and model data from Perturb-seq, single-cell and multi-omic sequencing, lineage tracing, chemogenetic screens, and related high-throughput experimental approaches.&lt;/p&gt;
&lt;p&gt;Both roles are highly collaborative, partnering closely with experimental scientists, bioinformatics infrastructure teams, machine learning researchers, and Arc investigators to identify biological mechanisms, nominate targets, and guide the design of future experiments.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;You want to understand biological mechanisms and are not satisfied with lists of differentially expressed genes; you want to understand why perturbations produce specific cellular outcomes.&lt;/li&gt;
&lt;li&gt;You have deep hands-on experience with single-cell, perturbational, or multi-omic data and are comfortable working with large, messy biological datasets.&lt;/li&gt;
&lt;li&gt;You think carefully about experimental design and enjoy collaborating across disciplines: you can discuss gene regulation, cellular identity, and assay design with experimentalists, and data models, statistics, and software with computational colleagues.&lt;/li&gt;
&lt;li&gt;You have a solid understanding of existing computational methods and their limitations. When they are insufficient to answer the questions at hand, you can adapt and extend them.&lt;/li&gt;
&lt;li&gt;You are excited by the opportunity to work in a mission-driven, open-science research institute with close ties to Stanford, UCSF, and UC Berkeley.&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Conduct tertiary analyses of large-scale Perturb-seq, single-cell sequencing, multi-omic, and functional genomics datasets to identify functional relationships between genes, regulatory programs, and cellular phenotypes.&lt;/li&gt;
&lt;li&gt;Depending on your track, this includes work such as e.g. guide assignment, perturbation-effect estimation, and interaction modeling for pooled CRISPR screens, or trajectory and cell-state analysis of microglial state transitions in neurodegeneration.&lt;/li&gt;
&lt;li&gt;Partner with experimental teams on iterative study design, analysis, interpretation, and validation, discovering computational insights that translate into testable biological hypotheses.&lt;/li&gt;
&lt;li&gt;Work closely with bioinformatics and data infrastructure teams to define clean handoffs from primary and secondary analysis into exploratory and mechanistic modeling.&lt;/li&gt;
&lt;li&gt;Contribute to Arc&#39;s Virtual Cell and Alzheimer&#39;s Disease Initiatives by generating, analyzing, visualizing, and interpreting datasets that fuel predictive models.&lt;/li&gt;
&lt;li&gt;Develop reusable analysis notebooks, dashboards, software tools, benchmarks, and data resources that allow Arc scientists to explore complex datasets effectively.&lt;/li&gt;
&lt;li&gt;Present findings to internal stakeholders, and contribute to preprints or open-source projects when the opportunity arises or as needed.&lt;/li&gt;
&lt;li&gt;Mentor colleagues and interns and contribute to a collaborative, intellectually rigorous team environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;PhD in computational biology, bioinformatics, genomics, systems biology, machine learning, computer science, molecular biology, or a related field, with 0–4 years of postdoctoral or professional research experience.&lt;/li&gt;
&lt;li&gt;Demonstrated track record of deriving biological insight from large-scale single-cell, perturbational, or multi-omic datasets.&lt;/li&gt;
&lt;li&gt;Hands-on experience with single-cell, perturbational, or multi-omic data, e.g. single-cell RNA-seq, Perturb-seq or CRISPR screens, single-cell ATAC-seq or multiome, including tertiary analysis, such as gene regulatory network inference, perturbation-effect or interaction modeling.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Expertise in at least one of the following:&lt;/strong&gt;&lt;/li&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;(a) Perturb-seq / CRISPR screen analysis at scale&lt;/strong&gt;, including guide assignment, perturbation-effect estimation, interaction modeling, batch correction, and interpretation of pooled genetic screens; &lt;strong&gt;or&lt;/strong&gt;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;(b) Single-cell analysis of microglia&lt;/strong&gt;, in the context of neurodegeneration and Alzheimer&#39;s disease biology.&lt;/li&gt;
&lt;/ul&gt;
&lt;li&gt;Python proficiency, with experience using modern scientific computing and data analysis ecosystems.&lt;/li&gt;
&lt;li&gt;Familiarity with reproducible computational workflows, version control, and high-performance or cloud computing environments.&lt;/li&gt;
&lt;li&gt;Biological intuition and the ability to collaborate effectively with experimental scientists.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills, with a track record of publications, preprints, open-source tools, or other scientific outputs.&lt;/li&gt;
&lt;li&gt;Ability to work in a fast-paced, ambitious, interdisciplinary research environment.&lt;/li&gt;
&lt;li&gt;Work a minimum of 3 days onsite in our Palo Alto office.&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Preferred qualifications&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Background in cell identity, reprogramming, RNA biology, cell engineering, neurobiology, immunology, cancer biology, or complex disease genetics.&lt;/li&gt;
&lt;li&gt;Familiarity with dimensionality reduction and gene module analysis techniques in the context of single-cell biology.&lt;/li&gt;
&lt;li&gt;Experience in a startup, technology center, research institute, or other highly collaborative environment where scientific direction and technical execution are tightly coupled.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $135,000 to $186,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc is seeking an experienced Senior Director of Disease Biology to lead target discovery through preclinical development for the Alzheimer&#39;s Disease Initiative (ADI). The core of the role is building a new team and the workflows that carry validated targets through hit to lead progression and into IND enabling studies. Alongside that build, this leader will direct Arc&#39;s existing in vivo and advanced cellular model teams to identify and validate novel targets, partnering with Arc&#39;s computational technology center to apply causal modeling and assemble a prioritized portfolio. The role also looks outward, drawing on expertise across the Arc community and engaging the broader Alzheimer&#39;s disease field so that the Initiative both learns from and contributes to progress beyond Arc.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Why this position could be the best job you’ve ever had&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;You will work alongside a world class team of biologists, functional genomics scientists, machine learning researchers, and technology developers united in building and interrogating virtual cells to identify first in class interventions for disease. The role calls for a long range strategy and the appetite for scientific risk that transformative innovation demands.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for a driven, resilient leader who is passionate about advancing how we understand disease and fearless in pursuing therapeutic opportunities that change patients&#39; lives. Someone who builds, grows, and mentors strong teams, sets clear direction, and brings creativity and rigor to complex, ambiguous problems to accelerate discovery into the clinic.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Build a new team to carry validated targets through drug discovery into preclinical programs.&lt;/li&gt;
&lt;li&gt;Guide those programs through to lead optimization, partnering with chemistry and ADI model teams to prioritize candidates and generate in vitro and in vivo proof of concept data.&lt;/li&gt;
&lt;li&gt;Lead target discovery for the Initiative, translating genetic, functional genomics, and disease mapping findings into biologically grounded therapeutic targets.&lt;/li&gt;
&lt;li&gt;Lead Arc&#39;s existing in vivo and in vitro ADI discovery teams, shaping their work to sharpen target identification and validation.&lt;/li&gt;
&lt;li&gt;Partner with computational biology and machine learning teams to surface new pathway insight, apply causal modeling to test target hypotheses, and draw on patient genetics and sample databases to validate and prioritize candidates.&lt;/li&gt;
&lt;li&gt;Align priorities across the target discovery and preclinical teams so concurrent programs move in a coordinated way.&lt;/li&gt;
&lt;li&gt;Collaborate across the Arc community to coordinate experimental approaches and analysis, and to deepen our collective understanding of Alzheimer&#39;s disease biology.&lt;/li&gt;
&lt;li&gt;Manage CRO and external partner relationships, with support from Program Management, to advance AD model generation and preclinical studies.&lt;/li&gt;
&lt;li&gt;Represent discovery and preclinical strategy in cross functional target review and portfolio prioritization discussions.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in neuroscience, immunology, cell biology, genetics, pharmacology, or a related field.&lt;/li&gt;
&lt;li&gt;Extensive experience leading target discovery in neurodegeneration, from disease biology and human genetics through target validation.&lt;/li&gt;
&lt;li&gt;Track record advancing programs from validated target through lead optimization, in vivo proof of concept, and IND enabling studies, including building or partnering with the supporting toxicology and pharmacokinetics capabilities.&lt;/li&gt;
&lt;li&gt;Deep expertise developing or applying advanced 3D cellular models of neurodegenerative disease.&lt;/li&gt;
&lt;li&gt;Proven people leadership, including mentoring established scientific teams, building new teams and capabilities from the ground up, and running matrixed, cross functional programs.&lt;/li&gt;
&lt;li&gt;Strong partnership with computational biology and machine learning teams, applying causal modeling and human genetic data to target discovery and validation.&lt;/li&gt;
&lt;li&gt;Experience in a fast paced biotech or nonprofit research institute environment.&lt;/li&gt;
&lt;li&gt;Ability to work onsite in our Palo Alto office a minimum of four days per week.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Direct experience in Alzheimer&#39;s disease drug discovery.&lt;/li&gt;
&lt;li&gt;Hands-on experience generating and validating animal models of Alzheimer’s disease, including genetic risk variant models such as APOE4 and TREM2.&lt;/li&gt;
&lt;li&gt;Experience integrating computational and machine learning driven target prioritization into discovery strategy.&lt;/li&gt;
&lt;li&gt;Experience partnering with high throughput biology teams.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $263,500 to $325,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 300 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Mammalian Models Technology Center is seeking a motivated Senior Research Associate (SRA) to join the In Vivo Functional Genomics Team.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;In this position, you will contribute to execute large-scale in vivo perturbation screens aimed at mapping the genetic circuits that govern immune functions across different tissues. This work is integral to two key initiatives: the Virtual Cell Initiative, which seeks to build the first foundation model for accurate predictions about cell states, and the Alzheimer’s Disease Initiative, which applies these methods to find cures for Alzheimer&#39;s.&lt;/p&gt;
&lt;p&gt;This position offers an exceptional opportunity to apply and develop cutting-edge technologies to unveil the molecular principles that govern cellular fates. You will join a multidisciplinary team working at the crossroads of Immunology, Neuroscience, CRISPR technologies, Multi-omics and Computational biology. A key aspect of this role is the opportunity to collaborate closely with pioneering labs that have developed the foundational toolbox for functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You can work fast and are detail-oriented. You are careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to help.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a problem solver. It&#39;s common in science to come across issues you need to troubleshoot, and you pride yourself in your ability to independently and collaboratively troubleshoot complex problems in the lab.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Assist with research planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Contribute to our immune in vivo functional genomics screens across multiple tissues to dissect the circuits that shape mature immune functions&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Contribute to the generation an in vivo perturbation dataset with unprecedented scale to develop the in vivo branch of Arc’s Virtual Cell Initiative&lt;/li&gt;
&lt;li&gt;Contribute to our ongoing neuro-immune screens in mouse and NHP models to understand the causes and drivers of Alzheimer’s Disease&lt;/li&gt;
&lt;li&gt;Develop new single-cell and spatial methodologies tailored to our in vivo perturbation screens.&lt;/li&gt;
&lt;li&gt;Support large institutional genomic initiatives through efficient workflow execution and quality management&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Isolation of immune cells from various tissues using MACS and/or FACS.&lt;/li&gt;
&lt;li&gt;Perform Single-cell transcriptomic profiling of perturbed cells using 10X genomics and Split and pool methods&lt;/li&gt;
&lt;li&gt;Perform Spatial transcriptomic profiling of perturbed cells using established technologies and benchmark and develop new spatial methods tailored to our in vivo screens.&lt;/li&gt;
&lt;li&gt;Perform library cloning (CRISPR and ORFs) and viral vector production (Lentivirus and AAV).&lt;/li&gt;
&lt;li&gt;Operate Next Generation Sequencing (NGS) platforms&lt;/li&gt;
&lt;li&gt;Support routine lab activities, e.g., maintaining equipment, ordering/receiving supplies&lt;/li&gt;
&lt;li&gt;Maintain an organized and detailed lab notebook.&lt;/li&gt;
&lt;li&gt;Analyze and present data at meetings and seminars, as needed.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS or equivalent professional experience in biology, neuroscience, genetics, or another relevant field&amp;nbsp;&lt;/li&gt;
&lt;li&gt;BS degree, 4-5+ years of relevant experience or a MS degree, 2+ years of relevant postgraduate experience on CRISPR and/or single-cell genomics.&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience in molecular biology and single-cell genomics is a must for this role.&lt;/li&gt;
&lt;li&gt;Experience with tissue dissociation and flow cytometry and FACS&lt;/li&gt;
&lt;li&gt;Experience with cell culture&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Skills:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with library cloning (sgRNAs, ORFs, etc)&lt;/li&gt;
&lt;li&gt;Experience with animal handling and surgeries.&lt;/li&gt;
&lt;li&gt;Ability to analyze large and complex data sets using Python, R, or similar tools.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $84,250 to $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled Senior Research Associate to join the Functional Genomics team within the Genome Engineering Technology Center at the Arc Institute. This will be a fixed-term, 12-month position. This role is not eligible for visa sponsorship.&lt;/p&gt;
&lt;p&gt;In this role, you will serve as a dedicated producer of hematopoietic progenitor cells (HPCs), differentiating both parental and genetically edited human stem cells to supply high-quality HPCs for downstream research across multiple Tech Center teams. Your work will directly enable large-scale perturbation screening efforts that power Arc&#39;s Virtual Cell Initiative and Alzheimer&#39;s Disease Initiative.&lt;/p&gt;
&lt;p&gt;This is a production-focused role centered on planning, consistency, and throughput. You will routinely execute staggered weekly rounds of HPC production, working ahead of demand by coordinating with requesting teams, scaling each round to meet projected needs, and maintaining the reagent and consumable stocks required to keep production uninterrupted. With every lot, you will perform and document quality control assessments to ensure that the cells delivered meet defined standards set by the requesting teams. Beyond routine production, you will contribute to process optimization efforts aimed at further scaling output and reducing lot-to-lot variability.&lt;/p&gt;
&lt;p&gt;The ideal candidate is experienced in human stem cell culture and large-scale HPC differentiation, and proficient in a range of cellular, molecular, and functional quality-assessment methods. They execute and troubleshoot independently, with outstanding attention to detail and a commitment to dependable, reproducible work. They communicate proactively across teams and bring a continuous-improvement mindset to a high-volume cell culture workflow.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You take pride in producing consistent, high-quality results on a predictable schedule.&lt;/li&gt;
&lt;li&gt;You are diligent, meticulous, and committed to thorough documentation and good record-keeping practices.&lt;/li&gt;
&lt;li&gt;You are organized and plan ahead, keeping workflows, reagents, and timelines on track.&lt;/li&gt;
&lt;li&gt;You respect the process and are comfortable with routine execution while continuously identifying opportunities to troubleshoot and address bottlenecks.&lt;/li&gt;
&lt;li&gt;You communicate proactively and enjoy coordinating across teams to anticipate and meet demand.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced, collaborative, team-science environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Execute staggered weekly rounds of hematopoietic progenitor cell (HPC) production and banking with different human stem cell lines (e.g., parental and genetically edited) to support downstream research teams.&lt;/li&gt;
&lt;li&gt;Perform quality control (QC) assessments for each lot, which may involve flow cytometry, molecular, and functional assays, and ensure that delivered cells meet defined acceptance criteria defined by the requesting teams.&lt;/li&gt;
&lt;li&gt;Perform troubleshooting on failed productions, escalate and reschedule as needed to maintain supply continuity.&lt;/li&gt;
&lt;li&gt;Coordinate cross-functionally to forecast demand in advance, scaling each round of production accordingly to meet the projected needs of requesting teams.&lt;/li&gt;
&lt;li&gt;Maintain rigorous, organized documentation of production runs, QC outcomes, and cell distribution in our ELN/LIMS systems.&lt;/li&gt;
&lt;li&gt;Maintain inventory of key reagents, media, and consumables to ensure uninterrupted production, including proactive procurements.&lt;/li&gt;
&lt;li&gt;Establish, refine, and run an efficient end-to-end cell production platform spanning demand intake to final delivery.&lt;/li&gt;
&lt;li&gt;Contribute to process optimization efforts aimed at improving the scale, quality and lot-to-lot consistency of HPC production.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS degree in cell biology or related field with 4+/2+ years of relevant work experience. Industry or core-facility experience in cell production is strongly preferred.&lt;/li&gt;
&lt;li&gt;Proficiency in mammalian cell culture procedures and associated aseptic techniques, including direct hands-on experience with human stem cell (hESC/iPSC) maintenance and HPC differentiation at scale.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to execute reproducible, multi-step differentiation protocols consistently across repeated rounds.&lt;/li&gt;
&lt;li&gt;Experience performing and documenting QC assessments, which include flow cytometry, RT-qPCR, and colony-formation assays.&lt;/li&gt;
&lt;li&gt;Attention to detail and a track record of delivering high-quality work consistently.&lt;/li&gt;
&lt;li&gt;Strong organizational, planning, and time-management skills, with the ability to manage staggered production schedules and anticipate demand.&lt;/li&gt;
&lt;li&gt;Excellent communication skills and the ability to coordinate effectively across teams.&lt;/li&gt;
&lt;li&gt;Flexibility to work on weekends as needed to accommodate production schedules.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience developing or leveraging automation for quality cell production at scale.&lt;/li&gt;
&lt;li&gt;Prior experience independently optimizing processes and workflows to improve cell yield and quality.&lt;/li&gt;
&lt;li&gt;Hands-on experience with multiple differentiation protocols.&lt;/li&gt;
&lt;li&gt;Experience working with stem cells of diverse genetic backgrounds (e.g., patient-derived iPSCs).&lt;/li&gt;
&lt;li&gt;Familiarity with reagent inventory, operations management and LIMS platform (e.g., Benchling).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $84,250 to $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Why this position could be the best job you’ve ever had&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Join Arc&#39;s Alzheimer&#39;s Disease Initiative as the production engine behind a first-of-its-kind 3D brain-model screening program, where the cells you make drive disease-target discovery.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Senior Research Associate, In Vitro Screen Execution, to join the Cellular Models Technology Center for a fixed term of 12 months to&amp;nbsp; support the execution of arrayed genetic and chemical perturbation screens in disease-relevant 3D neural models. In this position, you will play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens. Through this work, you will play a critical role in the Institute&#39;s Alzheimer&#39;s Disease Initiative, an ambitious cross-functional effort aimed at identifying and developing drugs for rational therapeutic targets to combat devastating neurodegenerative disorders. This is a temporary contractor position based onsite 5 days a week in Palo Alto. This role is not eligible for visa sponsorship.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are highly independent in developing and executing experiments and workflow designs in line with the overall goals of the team and project. You plan and execute projects and individual experiments with independence.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You can work fast and are detail-oriented. You are careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.&lt;/li&gt;
&lt;li&gt;You use specialized skill sets to support lab teams and cross-functional projects. You collaborate effectively across teams without detailed guidance by your manager or mentor, including effectively engaging with people with different work styles. You directly mentor and train more junior RAs inside or outside your lab or team.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are comfortable carrying out the routine execution of tasks while identifying opportunities to troubleshoot and improve bottlenecks.&lt;/li&gt;
&lt;li&gt;Your organizational skills enable you to manage multiple concurrent projects, and your curiosity and creativity drive you to continuous learning.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Execute culture, quality control and validation of complex in vitro 3D neural and glial models.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.&lt;/li&gt;
&lt;li&gt;Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models.&lt;/li&gt;
&lt;li&gt;Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.&lt;/li&gt;
&lt;li&gt;Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.&lt;/li&gt;
&lt;li&gt;Collaborate with other teams at Arc to coordinate screening steps and sample transfer.&lt;/li&gt;
&lt;li&gt;Analyze and present experimental data at internal meetings and seminars.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience&lt;/li&gt;
&lt;li&gt;Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar), with reliable, reproducible results.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to execute multiple cell culture protocols with precision and to transition between them accurately, maintaining fidelity to each protocol&#39;s specific requirements (workflow, media, and timeline).&lt;/li&gt;
&lt;li&gt;Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts.&lt;/li&gt;
&lt;li&gt;Excellent aseptic technique and consistent cell-culture practice held to a high, production-type standard.&lt;/li&gt;
&lt;li&gt;Meticulous documentation and record-keeping; comfort working to a production schedule, and basic data tracking and analysis.&lt;/li&gt;
&lt;li&gt;Work onsite in our Palo Alto office 5 days per week. Occasional weekend work may be required.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Hands-on experience handling high throughput plate formats and automation methods.&lt;/li&gt;
&lt;li&gt;Experience with LIMS systems, ideally Benchling.&lt;/li&gt;
&lt;li&gt;Experience analyzing large data sets preferably using data scripting tools such as Python or R.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $84,250 to $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.&lt;/p&gt;
&lt;p&gt;Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they&#39;re free to pursue high-risk, long-term research without commercial pressures. Arc&#39;s Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.&lt;/p&gt;
&lt;p&gt;Our two Institute Initiatives reflect this model in action:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/virtual-cell-initiative&quot;&gt;&lt;strong&gt;Virtual Cell Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&amp;nbsp; accelerating the path from biological insight to clinical trials.&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://arcinstitute.org/alzheimers-disease-initiative&quot;&gt;&lt;strong&gt;Alzheimer&#39;s Disease Initiative&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;:&lt;/strong&gt; Mapping the genes, pathways, and environmental factors behind Alzheimer&#39;s disease to develop drug candidates that address root causes.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly motivated, well-organized, and technically proficient Senior Research Associate to join the Genomics Platform of the Multi-omic technology center. This will be a fixed-term, 12-month position based onsite 5 days a week in Palo Alto. This role is not eligible for visa sponsorship.&lt;/p&gt;
&lt;p&gt;In this role, you will report to the Associate Director of the Genomics Platform and play a key role in delivering high-quality sequencing data for institute-scale initiatives and investigator-led research. You will work closely with scientists across Arc to coordinate sequencing submissions, perform sequencing operations, ensure rigorous quality control, and help maintain efficient, reliable production workflows across multiple next-generation sequencing platforms. This is primarily a production sequencing operations role. Success in this role is measured by delivering high-quality sequencing data through reliable execution, strong operational discipline, and excellent collaboration with sample submitters.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Job responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform NGS library QC, pooling, and sequencing operations for bulk and single-cell workflows across multiple platforms (Illumina, Ultima Genomics).&lt;/li&gt;
&lt;li&gt;Partner with investigators and Technology Centers to coordinate sequencing projects, review submissions, and guide users on workflows, requirements, and troubleshooting.&lt;/li&gt;
&lt;li&gt;Utilize and help improve laboratory information management systems (LIMS/ELN) for sample tracking and sequencing operations.&lt;/li&gt;
&lt;li&gt;Carry out continuous process improvement for data generation workflows and procedures.&lt;/li&gt;
&lt;li&gt;Maintain sequencing schedules, sample tracking records, and SOPs to support reliable platform operations.&lt;/li&gt;
&lt;li&gt;Summarize, document, and present results to stakeholders within and outside the Genomics Platform group.&lt;/li&gt;
&lt;li&gt;Support routine lab activities, e.g. maintaining equipment, ordering / receiving supplies.&lt;/li&gt;
&lt;li&gt;Perform other duties as assigned and contribute to a collaborative, high-quality lab culture.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS degree in genomics, molecular biology, biochemistry, biology or related field&lt;/li&gt;
&lt;li&gt;BS with 4+ years (or MS with 2+ years) of relevant post-graduate experience, preferably in the biotechnology/pharmaceutical industry in a clinical diagnostics, biotech or research lab setting.&lt;/li&gt;
&lt;li&gt;Firm understanding of fundamental molecular biology concepts.&lt;/li&gt;
&lt;li&gt;Hands-on experience with basic molecular biology and QC techniques including nucleic acid extraction, purification and quantification (using Qubit and Bioanalyzer/ Tapestation), PCR/RT-PCR, qPCR.&lt;/li&gt;
&lt;li&gt;Expertise in NGS technologies and workflows, including library preparation, library quality assessment, pooling strategies, sequencing operations, and Illumina instrumentation.&lt;/li&gt;
&lt;li&gt;Strong interpersonal skills with a demonstrated ability to collaborate with diverse scientific users and deliver excellent customer support in a shared platform setting.&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills.&lt;/li&gt;
&lt;li&gt;Strong organizational and analytical skills, with high attention to detail in executing standardized workflows across multiple concurrent projects.&lt;/li&gt;
&lt;li&gt;Drive for excellence and a self-starter.&lt;/li&gt;
&lt;li&gt;Demonstrated problem solving skills and ability to troubleshoot technical issues&lt;/li&gt;
&lt;li&gt;Ability to work with minimal to moderate supervision in a dynamic environment and under tight deadlines.&lt;/li&gt;
&lt;li&gt;Experience with automation platforms and high-throughput molecular workflows is a plus.&lt;/li&gt;
&lt;li&gt;Experience with single-cell RNA-sequencing using the 10x Genomics or other platform is a plus.&lt;/li&gt;
&lt;li&gt;Experience with processing mammalian cells and tissues is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $84,250 to $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Open Roles at Arc

Technology Centers

Director, Machine Learning, Alzheimer's Disease Initiative

Palo Alto, CA

Director, Machine Learning, Virtual Cell Initiative

Palo Alto, CA

Senior Research Associate, HPC Production (Fixed-Term Contract)

Palo Alto, CA

Senior Research Associate, Functional Genomics

Palo Alto, CA

Senior Research Associate, NGS - Genomics Platform (Fixed-Term Contract)

Palo Alto, CA

Scientist, Computational Biology

Palo Alto, CA

Senior Director, Disease Biology

Palo Alto, CA

Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)

Palo Alto, CA

Core Labs

Postdoctoral Researcher, Jain Lab

Palo Alto, CA

Postdoctoral Researcher, Horns Lab

Palo Alto, CA

Postdoctoral Researcher, Zhou Lab

Palo Alto, CA

Postdoctoral Researcher, ML for Biology, Hsu Lab

Palo Alto, CA

Postdoctoral Researcher, Biological Design, Hsu Lab

Palo Alto, CA

Research Associate II, Konermann Lab

Palo Alto, CA

Lab Manager, Hie & Pluvinage Labs

Palo Alto, CA

Research Associate II, Horns Lab

Palo Alto, CA

In Vivo Research Associate II, Konermann Lab

Palo Alto, CA

Postdoctoral Researcher, Neuro-Immune Interactions, Pluvinage Lab

Palo Alto, CA

Operations

FP&A Manager

Palo Alto, CA

Scientific Program Manager Lead

Palo Alto, CA

People Operations & Compensation Lead

Palo Alto, CA

Chief of Staff

Palo Alto, CA

Executive Assistant

Palo Alto, CA

Laboratory Operation Assistant (Temp to Perm)

Palo Alto, CA

General Counsel

Palo Alto, CA

Don’t see your role?

Recruitment Fraud Notice

Sign up to receive Arc Institute updates