Palo Alto, CA

Flow Cytometry Specialist

Core Facilities

Postdoctoral Researcher, Jain Lab

Postdoctoral Researcher, Gilbert Lab

Research Associate I, Konermann Lab

Postdoctoral Researcher, Pluvinage Lab

Scientist, Functional Genomics, Konermann Lab

Research Associate II, Konermann Lab

Postdoctoral Researcher, Horns Lab

Scientist, Genome Editing Technologies, Hsu Lab

Postdoctoral Researcher, Konermann & Goodarzi Labs

Scientist, Antibody Discovery, Horns Lab

Research Associate I, Arce Lab

Core Laboratories

Faculty & Fellows

FP&A Manager

Operations

Director, Machine Learning, Alzheimer's Disease Initiative

Senior Machine Learning Research Scientist

Associate Director, Genomics Platform

Senior Research Associate, Functional Genomics

Director, Computational Biology

Scientist, Cell Engineering

Scientist, Functional Genomics, Virtual Cell Initiative

Senior Research Associate, Single Cell Screening

Technology Centers

No Department

&lt;h4&gt;About Arc Institute&lt;/h4&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;h4&gt;About the Position&lt;/h4&gt;
&lt;p&gt;We are seeking an exceptional scientific leader for the Associate Director of Genomics Platform within the Multiomics Technology Center. You will work cross-functionally across experimental and computational teams from Arc’s Technology Centers and Core Investigator labs, manage a high-performing team of research scientists and associates in your Genomics Platform, lead our efforts in onboarding and scaling up next-generation sequencing technologies for Arc’s large-scale institute initiatives, and serve as a technical expert in genomics technologies across the institute. You will play a central role in enabling large-scale sequencing for Arc’s Virtual Cell Initiative, which aims to create the first AI foundation model that makes accurate predictions of cellular responses to drug perturbations.&lt;/p&gt;
&lt;p&gt;The ideal candidate combines deep scientific expertise in advanced sequencing technologies with proven people and project management skills and a track record of delivering large-scale projects under tight deadlines. This role requires a team-oriented mindset focused on delivering high-quality, rapid results to users and collaborators across the Institute.&lt;/p&gt;
&lt;h4&gt;About You&lt;/h4&gt;
&lt;ul&gt;
&lt;li&gt;Scientific expert and team leader: You have deep expertise in advanced sequencing technologies and excel at developing high-performing scientific teams through goal execution and mentorship.&lt;/li&gt;
&lt;li&gt;Service-oriented and user-focused: You love enabling others&#39; success, treat collaborators and users as valued customers, and consistently deliver solutions that exceed expectations.&lt;/li&gt;
&lt;li&gt;Systems thinker and process optimizer: You naturally think at scale, building efficient workflows and automated processes for large-scale research while balancing scientific rigor with operational demands.&lt;/li&gt;
&lt;li&gt;Results-driven under pressure: You thrive in fast-paced environments with tight deadlines, excel at prioritization, delivering complex projects on time in high-throughput settings.&lt;/li&gt;
&lt;li&gt;Collaborative: You enjoy building strong working relationships with users and collaborators, and excel at collaborating with cross-functional teams to achieve collective goals.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Adaptable learner: You stay current with new genomics technologies, demonstrate sound judgment in implementing innovations, can pivot strategies effectively based on organization needs.&lt;/li&gt;
&lt;/ul&gt;
&lt;h4&gt;In this position you will&lt;/h4&gt;
&lt;ul&gt;
&lt;li&gt;Manage and professionally develop a fully funded Genomics Platform team of 4 FTEs, provide hands-on guidance and mentorship to scientists and research associates&lt;/li&gt;
&lt;li&gt;Oversee day-to-day operations of the Genomics Platform in a high-scale production environment&lt;/li&gt;
&lt;li&gt;Collaborate with cross-functional Technology Center teams (Genome Engineering, Data Infrastructure, Machine Learning, etc.) to enable large-scale, single cell sequencing dataset generation for Virtual Cell Initiative&lt;/li&gt;
&lt;li&gt;Manage multiple complex projects simultaneously, and ensuring timely execution under tight deadlines&lt;/li&gt;
&lt;li&gt;Drive initiatives to improve platform operational efficiency and turnaround time, develop and implement continuous improvement strategies&lt;/li&gt;
&lt;li&gt;Serve as a subject matter expert in genomic, epigenomic, and transcriptomic sequencing technologies, provide expert consultation and training to Arc users on advanced NGS technologies and the Genomics Platform&lt;/li&gt;
&lt;li&gt;Stay current with rapidly evolving scientific fields, identify, evaluate and implement new cutting-edge methodologies&lt;/li&gt;
&lt;li&gt;Attend and present at internal meetings, share project plans and results and ensure cross team alignment&lt;/li&gt;
&lt;li&gt;Establish and maintain relationships with external vendors and partners to facilitate seamless collaboration&lt;/li&gt;
&lt;/ul&gt;
&lt;h4&gt;Requirements&lt;/h4&gt;
&lt;ul&gt;
&lt;li&gt;PhD, MD, or MD/PhD in genomics, molecular biology, biochemistry, or related field&lt;/li&gt;
&lt;li&gt;8+ years of relevant experience in academic, biotechnology or pharmaceutical industry, with demonstrated success in high-scale production settings&lt;/li&gt;
&lt;li&gt;3+ years of people management experience leading and growing scientific teams of 3 or more members&lt;/li&gt;
&lt;li&gt;Deep expertise in advanced sequencing platforms, particularly single-cell sequencing technologies&lt;/li&gt;
&lt;li&gt;Extensive knowledge of NGS library preparation workflows and computational aspects of multi-omic profiling&lt;/li&gt;
&lt;li&gt;Experience implementing process improvements and automation in production settings&lt;/li&gt;
&lt;li&gt;Proven record of delivering large, complex projects under tight deadlines in fast-paced, high-throughput environments&lt;/li&gt;
&lt;li&gt;Strong organizational skills and proven record managing multiple concurrent projects and priorities&lt;/li&gt;
&lt;li&gt;Strong service-oriented mindset with focus on delivering exceptional results to internal and external users&lt;/li&gt;
&lt;li&gt;Demonstrated ability to provide training and technical consultation to diverse scientific audiences&lt;/li&gt;
&lt;li&gt;Outstanding written and verbal communication skills&lt;/li&gt;
&lt;li&gt;Experience in establishing and maintaining collaborative relationships across interdisciplinary teams&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $160,000 to $207,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;br&gt;&lt;br&gt;&lt;/p&gt;

Headquarters - 3181 Porter Drive, Palo Alto, CA

&lt;p&gt;&lt;strong&gt;About Arc Institute&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc employs more than 300 people, with $650M+ in committed funding and a state of the art new lab facility in Palo Alto.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Why this position could be the best job you’ve ever had&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Bridge the Gap Between Data and Discovery:&lt;/strong&gt; Move beyond standard pipelines. You will lead our &quot;Tertiary Analysis&quot; work, transforming raw counts into mechanistic analyses that explain how genes, drugs, and environments collide.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Join a New Type of Research Org:&lt;/strong&gt; Work within a structure that fuses the high-velocity execution of a startup with the intellectual rigor of a world-class academic institute.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Command &quot;Gold Standard&quot; Datasets:&lt;/strong&gt; Gain exclusive access to massive, full-production datasets - from T-cells and NGN2 neurons to deep chemogenetic screens - designed specifically for large-scale discovery.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Lead with Autonomy:&lt;/strong&gt; While a sister team handles the essential bioinformatics infrastructure and QC, your mandate builds on top of this by developing the novel methods and analyses needed to uncover new biology (e.g. gene-module detection tools, etc).&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Open science and open source&amp;nbsp;&lt;/strong&gt;- we publish our breakthroughs openly to accelerate scientific progress.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Biological Mechanism Minded:&lt;/strong&gt; You aren&#39;t satisfied with a list of differentially expressed genes. You are obsessed with the &quot;why&quot;: building explanatory models that map the complex interactions between genetics, compounds, and the cellular environment.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Empathetic Leader:&lt;/strong&gt; You enjoy and derive energy from the &quot;human&quot; side of science. You are a dedicated mentor who views the professional and scientific growth of your team as one of your primary metrics of success.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Scientific Translator&lt;/strong&gt;: You are a rare hybrid who speaks the language of both the wet lab and bioinformatics. You can debate mechanistic biology with a neuroscientist and then pivot to discuss algorithmic efficiency with a tool-builder.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Production Scaled&lt;/strong&gt;: You have experience working with massive, &quot;full-production&quot; datasets. You know how to extract biological signal from T-cell assays or chemogenetic screens at scale in a fast paced, collaborative environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Build and manage Arc’s Computational Biology team.&lt;/li&gt;
&lt;li&gt;Actively mentor and provide guidance to research staff, developing them both professionally and scientifically.&lt;/li&gt;
&lt;li&gt;Develop and refine cutting-edge tertiary analysis and explanatory modeling approaches across Arc’s key research areas, including functional genomics, transcriptomics, epigenomics, and proteomics.&lt;/li&gt;
&lt;li&gt;Integrate multiple data types to elucidate functional connectivity between genes, transcripts, and proteins, with the goal of building mechanistic models of gene networks and interactions.&lt;/li&gt;
&lt;li&gt;Be a key participant in a collaborative, Institute-wide initiative on functional genomics focused on building virtual cells and the mechanistic understanding of late-onset Alzheimer’s disease.&lt;/li&gt;
&lt;li&gt;Partner with Arc’s Core Investigators and Technology Centers to advance research across the institute and create a culture of collaboration and excellence.&lt;/li&gt;
&lt;li&gt;Engage in and manage internal and external research collaborations.&lt;/li&gt;
&lt;li&gt;Attend and present at team meetings to share results, plan projects and experiments, and ensure that projects support team goals.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD, MD, or MD/PhD in a relevant field and 12+ years of relevant experience in industry and/or academic settings; including 5+ years of experience managing, leading, and growing scientific teams.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Extensive experience with genomics, transcriptomics, epigenomics, and single cell sequencing data analysis.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience developing innovative computational algorithms to address biological questions.&lt;/li&gt;
&lt;li&gt;Outstanding written and verbal communication skills are required for research presentations, SOP development, and publications.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects, and enjoy working in a fast-paced team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $233,500-$287,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;h2&gt;&lt;strong&gt;About the Position&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;We are searching for an exceptional scientific leader to establish a new team within Arc Institute’s Computational Technology Center, serving as the Director, Machine Learning for our Alzheimer&#39;s Disease Initiative (ADI).&amp;nbsp;&lt;/p&gt;
&lt;p&gt;This ambitious initiative spans Arc&#39;s Technology Centers and Core Investigator Laboratories and focuses on high-throughput interrogation of neurodegeneration and Alzheimer&#39;s disease mechanisms using advanced gene editing and functional genomics approaches. As the Machine Learning Research Lead, ADI, you will spearhead development of sophisticated machine learning foundation models to capture cell states and infer gene regulatory networks and causal relationships to predict therapeutic interventions.&lt;/p&gt;
&lt;p&gt;This position offers the rare opportunity to build and lead a world-class team while making direct contributions to understanding and potentially treating Alzheimer&#39;s disease through state-of-the-art computational biology and machine learning approaches.&lt;/p&gt;
&lt;h2&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;You are passionate about machine learning and computational biology&lt;/strong&gt;, with expertise in applying cutting edge ML approaches to biological systems&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You excel at developing interpretable machine learning approaches&lt;/strong&gt;, such as variational inference and causal modeling methods&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You are excited about building and leading a technical team while remaining hands-on&lt;/strong&gt; with foundation model development and implementation.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You thrive in collaborative, multidisciplinary environments&lt;/strong&gt; and enjoy working with both computational scientists and wet lab biologists&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;You are a continuous learner who stays current with the latest developments,&lt;/strong&gt; in both machine learning and neuroscience&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;strong&gt;In This Position, You Will&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;Attract, build and lead a team of exceptional machine learning research scientists dedicated to developing foundation models for cellular systems in Alzheimer&#39;s disease&lt;/li&gt;
&lt;li&gt;Develop and execute on a roadmap of interpretable machine learning approaches to understand disease mechanisms, with emphasis on variational inference, causal modeling, as well as modern transformer- and diffusion-based architectures&lt;/li&gt;
&lt;li&gt;Work closely with experimentalists on brain organoid/spheroid cellular models as well as &lt;em&gt;in vivo&lt;/em&gt; models, working with scRNA-seq, Perturb-seq and other datasets to unravel causal gene pathways relevant to Alzheimer’s disease&lt;/li&gt;
&lt;li&gt;Develop predictive modeling approaches to identify how perturbations can move cell states from high risk Alzheimer’s profiles back to healthy / low risk states&lt;/li&gt;
&lt;li&gt;Collaborate closely with experimental biologists to ensure ML models are grounded in disease biology and can feedback into future experimental strategies&lt;/li&gt;
&lt;li&gt;Foster collaborations with external partners in the computational biology and neuroscience communities&lt;/li&gt;
&lt;li&gt;Publish high-impact research through preprints, journal publications, open source code, and presentations at leading conferences&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;strong&gt;Required Qualifications&lt;/strong&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, or related quantitative field&lt;/li&gt;
&lt;li&gt;7+ years of relevant experience with a minimum of 3 years of people management experience&lt;/li&gt;
&lt;li&gt;Strong research background with experience in academic settings (university, research institute) and/or biotech/pharmaceutical industry with a focus on scientific innovation&lt;/li&gt;
&lt;li&gt;Proven expertise in machine learning applications to biological datasets, with specific experience in single-cell profiling data and foundation model development&lt;/li&gt;
&lt;li&gt;Deep experience with interpretable machine learning approaches for biological systems (e.g. variational inference methods).&lt;/li&gt;
&lt;li&gt;Advanced technical skills in machine learning frameworks, particularly PyTorch, and ideally experience with model training at scale&lt;/li&gt;
&lt;li&gt;Publications in top-tier journals in computational biology and machine learning&lt;/li&gt;
&lt;li&gt;Excellent communication skills with ability to present complex machine learning concepts to both computational and biological audiences&lt;/li&gt;
&lt;li&gt;Proven ability to remain technically hands-on while providing effective team leadership, mentorship, and management&lt;/li&gt;
&lt;li&gt;Background in neurodegeneration research including familiarity with Alzheimer&#39;s disease datasets, pathways, networks, disease mechanisms, and eQTL analysis is a plus&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $338,500 to $400,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Funding:&lt;/strong&gt;&amp;nbsp;Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Technology:&lt;/strong&gt;&amp;nbsp;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Support:&lt;/strong&gt;&amp;nbsp;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Culture:&lt;/strong&gt;&amp;nbsp;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;In this vital role, you will have the opportunity to shape the future of the flow cytometry core service at Arc, coordinating and managing instrument usage, user training, and day-to-day operations. You will operate analytical and sorting cytometers, with a strong focus on advising research teams on method development, assay design, and data analysis. Beyond core operations, you will help shape the strategic direction of flow cytometry at Arc—benchmarking new technologies, identifying opportunities for innovation, and driving collaborative initiatives across the institute. This position combines hands-on technical expertise with scientific leadership and community engagement.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li class=&quot;p1&quot;&gt;You are a skilled and passionate flow cytometry expert who thrives at the intersection of cutting-edge technology and collaborative science.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;You are a collaborative and solutions-oriented scientist with deep expertise in flow cytometry.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;You have a natural ability to translate complex scientific concepts into clear, accessible training materials, and you take pride in empowering laboratory personnel at all levels to work safely and effectively with flow cytometry instrumentation.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;You bring a strategic mindset to assay development, panel design, and data interpretation, and you are confident leading cross-institute initiatives that push the boundaries of what flow cytometry can achieve.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;You are a proactive communicator who enjoys sharing knowledge — whether through hands-on demos, internal presentations, or talks at major scientific conferences — and you are excited by the opportunity to shape Arc&#39;s reputation as an innovation leader in the field.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li class=&quot;p1&quot;&gt;Develop a clear training strategy, overview of training pathways and materials, and promote easy access to training&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Train and assist laboratory personnel with respect to the use of flow cytometry equipment and safety procedures.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Provide strategic direction in assay development, panel design, troubleshooting, and data interpretation. Run data analysis and interpretation of data generated at the FACS facility&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Lead cross-institute initiatives that leverage flow cytometry.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Stay at the forefront of advancements in flow cytometry technology, instrumentation, and analytical methodologies. Run benchmarking of relevant technologies and share insights with the Arc community via demos and presentations.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Identify emerging opportunities where flow cytometry can unlock new biological insights aligned with Institute goals.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Drive scientific discourse through presentations at major conferences, serve as a thought leader in the flow community, and contribute to Arc&#39;s reputation as an innovation leader.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Increased capacity to operate analytical flow cytometry analyzers &amp;amp; sorters&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Backup to maintain and troubleshoot flow cytometry instruments. You must be comfortable performing hands-on troubleshooting and solving basic instrument problems as they arise.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Backup as a shared point of contact with the manufacturer’s technical support and field service engineering teams to coordinate instrument preventative maintenance and repairs as needed.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Help with equipment management and recharge program in concert with the Lab Ops team to minimize equipment downtime and maintain equipment service logs.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Backup management of access for endusers, depending on training requirements.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Backup monitoring and management of the supply of all commonly required fluids, supplies and consumables.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Help maintain laboratory safety in BSL2 and BSL2+ environments for everyone that accesses the laboratory &amp;amp; help with risk assessments&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li class=&quot;p1&quot;&gt;Doctorate/Masters or BA degree in relevant discipline with a total of&amp;nbsp;8 or more years of Cytometry experience.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Extensive expertise in flow cytometry; strong understanding of cytometry platforms and instrumentation, equipment support,&amp;nbsp;and assay development.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Working knowledge of Full Spectrum Flow cytometry. In addition, knowledge of how to integrate flow &amp;amp; imaging cytometry efforts with adjacent single cell technologies (e.g., RNA seq, CRISPR screens, etc) would be preferred.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Proficiency in flow cytometry analysis software such as FlowJo, FCS Express, and/or OMIQ.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Good documentation practices &amp;amp; scientific conduct as defined by standard operating procedures.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Ability to work later hours, as required.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li class=&quot;p1&quot;&gt;Proven ability to interact with stakeholders to understand program needs, assay specifics, timelines, and data delivery.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Experience of leveraging varied AI/ML analytical platforms as they emerge into our industry &amp;amp; work in a team structure with data scientists in synergy.&lt;/li&gt;
&lt;li class=&quot;p1&quot;&gt;Facs Core management experience a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;The base salary range for this position is $104,500 - $128,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;S&lt;strong&gt;upport: &lt;/strong&gt;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 300 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/h3&gt;
&lt;p&gt;We are seeking an independent and analytical FP&amp;amp;A Manager to join our Financial Planning &amp;amp; Analysis (FP&amp;amp;A) team. This critical role will partner closely with key budget owners in our Technology Centers and Core Labs, driving the annual budgeting process, project-specific forecasting, and strategic decision-making. The ideal candidate will possess a strong foundation in financial modeling, experience at a science organization, and a proven ability to translate data into actionable insights for leadership.&lt;/p&gt;
&lt;h3&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;You are deeply analytical with a knack for effectively communicating that information visually and verbally&lt;/li&gt;
&lt;li&gt;You are a team player; you like to work as a team to help people get their jobs done&lt;/li&gt;
&lt;li&gt;You are detail-oriented and have a passion for organized processes and structured systems&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are familiar with our science and motivated about Arc’s mission&lt;/li&gt;
&lt;li&gt;You are a life long learner&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Lead the development and presentation of Arc’s annual operating budget, long-range strategic plans, and forecasts for our Institute Initiatives, research labs, and operational units.&lt;/li&gt;
&lt;li&gt;Partner directly with budget owners (specifically CSO, CTO, and COO organizations) to ensure financial plans align with strategic goals and provide detailed variance analysis against prior forecasts and budget.&lt;/li&gt;
&lt;li&gt;Develop scenario-driven financial models for key Institute Initiatives, new scientific programs, and capital expenditures.&lt;/li&gt;
&lt;li&gt;Drive continuous improvement in FP&amp;amp;A processes, reporting automation, and financial system utilization (e.g., Netsuite, Prendio).&lt;/li&gt;
&lt;li&gt;Support strategic vendor negotiations to reduce our operational costs.&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor&#39;s degree in Finance, Economics, or a related quantitative field and 5-8 years of experience in a demanding finance or analytical role.&lt;/li&gt;
&lt;li&gt;Demonstrated experience leading and executing the core functions of corporate FP&amp;amp;A, including budgeting, forecasting, and reporting, ideally within a fast-paced Technology or Biotechnology company.&lt;/li&gt;
&lt;li&gt;Prior experience as an Investment Banking Analyst (2-3 years) OR experience as a Consultant at a major/large consulting firm program (2-3 years). This experience must have provided deep exposure to financial analysis, rigorous modeling techniques, and effective communication of data.&lt;/li&gt;
&lt;li&gt;Exceptional proficiency with spreadsheets (advanced modeling, pivot tables, lookups, chart visualizations).&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;h3&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;Educational background (e.g., degree or advanced coursework) or professional experience in the Biosciences, Biotech, and/or related fields is highly desirable.&lt;/li&gt;
&lt;li&gt;Experience with financial planning systems (e.g., Netsuite Planning, Adaptive Planning) is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $116,750 to $144,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex, multimodal tools. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/gilbertlab&quot; target=&quot;_blank&quot;&gt;The Gilbert Lab&lt;/a&gt;&amp;nbsp;is looking for motivated, hard-working and curious applicants. Our expertise is in synthetic biology, functional genomics and epigenetics. We have a long standing interest in using CRISPR approaches to control transcription. We are focused on utilizing our expertise to tackle big problems in human biology such as how cellular identity and the epigenome are&amp;nbsp; determined and maintained. Lastly, we are focused on leveraging our expertise in epigenetics and synthetic biology to design new therapeutic strategies in the context of cancer, viral biology and neurodegeneration.&lt;/p&gt;
&lt;p&gt;The questions we ask:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;How are genes turned on and off?&lt;/li&gt;
&lt;li&gt;How are mechanisms of epigenetic memory established and maintained?&lt;/li&gt;
&lt;li&gt;Which genes drive complex disease phenotypes and what are their mechanisms? How can we modulate these for therapeutic means?&amp;nbsp;&lt;/li&gt;
&lt;li&gt;How can we use synthetic biology approaches to discover therapeutic strategies and design new gene, protein and small molecule therapeutics?&lt;/li&gt;
&lt;li&gt;How can we deliver genetic medicines to the right cell types in the body?&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The approach we take: CRISPR screens, high throughput synthetic biology, perturb-seq, in vitro disease models including iPSC models and primary cells, in vivo disease models.&lt;/p&gt;
&lt;p&gt;Post-docs will be encouraged to lead independent projects resulting in &lt;a href=&quot;https://scholar.google.com/citations?user=wlqxB00AAAAJ&amp;amp;hl=en&quot; target=&quot;_blank&quot;&gt;high impact publications&lt;/a&gt;, present at conferences and prepare for long-term careers in academia or industry.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are extremely curious and self-motivated to push the boundaries of biotechnology and/or biomedical research.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adapt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited by solving puzzles that have a translational impact and/or creating new therapeutic approaches.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Design, perform and analyze experiments&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Keep appropriate experimental records and documentation&lt;/li&gt;
&lt;li&gt;Analyze results with the Principal Investigator&lt;/li&gt;
&lt;li&gt;General lab maintenance as well as operation and maintenance of equipment and instruments.&lt;/li&gt;
&lt;li&gt;Collaborate with post-docs, students and employees&lt;/li&gt;
&lt;li&gt;May mentor/train research associates, technicians, and students.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Publish, present, and represent that lab in journals and conferences.&lt;/li&gt;
&lt;li&gt;Present at lab meetings, and participate in Arc-wide activities (seminars, symposiums, etc).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (MD, PhD, VMD, or DDS) in the area directly related to the field of research specialization.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support: &lt;/strong&gt;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/hornslab&quot; target=&quot;_blank&quot;&gt;The Horns Lab&lt;/a&gt; is seeking motivated, hard-working, and curious scientists. Our lab develops and applies technologies that bridge synthetic biology and genomics to answer fundamental and translational questions in human health, with a particular emphasis on immunology and neuroscience. We build new tools and use them to discover mechanisms in complex, dynamic systems, including the immune system, the brain, and other tissues.&lt;/p&gt;
&lt;p&gt;Postdocs in the lab are encouraged to lead ambitious, independent projects, resulting in high-impact publications, and to prepare for long-term careers in academia or industry. You will have the opportunity to collaborate widely across Arc, Stanford, and the broader Bay Area ecosystem, with access to strong platforms in our lab and our institutions for genomics, single-cell technologies, synthetic biology, computation, and experimental model systems.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;The questions we ask:&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;We are interested in how cells change over time and how those dynamics drive health and disease, and in building technologies to measure and control those dynamics. Example questions include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;How can we measure cellular dynamics non-destructively at scale, capturing histories, interactions, and functional outputs?&lt;/li&gt;
&lt;li&gt;How do extracellular vesicles (EVs) and virus-like particles (VLPs) interact with cells and tissues, and what molecular rules govern secretion, trafficking, uptake, and cargo delivery?&lt;/li&gt;
&lt;li&gt;How can we engineer delivery systems to target specific cell types and achieve efficient cytosolic delivery with minimal off-target effects?&lt;/li&gt;
&lt;li&gt;How do immune cells change state, migrate, and interact with tissues over time during homeostasis, inflammation, and disease?&lt;/li&gt;
&lt;li&gt;How can we profile immune receptor specificity and function at scale (TCRs/BCRs) to decipher immune recognition and control immune behaviors?&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;em&gt;The approaches we take:&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;We combine synthetic biology, genomics, cellular and mammalian models, and computation. Depending on the project, approaches may include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Mammalian synthetic biology&lt;/li&gt;
&lt;li&gt;Single-cell and spatial multi-omics&lt;/li&gt;
&lt;li&gt;Engineering and mechanistic study of EVs, VLPs, and other delivery systems&lt;/li&gt;
&lt;li&gt;Immune cell engineering and functional assays&lt;/li&gt;
&lt;li&gt;Sequencing-based measurement technologies&lt;/li&gt;
&lt;li&gt;Computational analysis and modeling of high-dimensional datasets&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are extremely curious and self-motivated.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and enjoy proposing and driving new research directions (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adopt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited to solve puzzles that have translational impact and/or enable new discovery and therapeutic approaches.&lt;/li&gt;
&lt;li&gt;You have a strong foundation in synthetic biology or genomics technology development, and/or in immunology or neuroscience.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct high-impact research: &lt;/strong&gt;Design, execute, and analyze experiments; take end-to-end ownership of a research project within the lab’s scientific focus, with guidance from the PI and increasing independence as you develop expertise.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a future scientific leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present at national and international conferences, and build a network of collaborators across Arc, Stanford, and beyond.\&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster scientific excellence: &lt;/strong&gt;Mentor and train research associates, technicians, and students; engage in Arc-wide activities (seminars, symposia); contribute to a collaborative research environment; maintain rigorous experimental records and documentation; and contribute to lab operations including protocol development and maintaining shared infrastructure.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (PhD, MD, MD/PhD, DVM, or equivalent) in bioengineering, synthetic biology, genomics, immunology, neuroscience, molecular biology, or a related field.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills, including a track record of scientific writing (manuscripts, preprints, or equivalent).&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Our research group thrives on bringing together people with diverse expertise. The best fit is typically someone strong in at least one area and excited to learn the others. Experience in one or more of the following is a plus:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Single-cell sequencing and analysis (scRNA-seq, scATAC-seq, CITE-seq)&lt;/li&gt;
&lt;li&gt;Spatial transcriptomics and multi-omics&lt;/li&gt;
&lt;li&gt;Pooled perturbation screens (CRISPRi/a/KO, Perturb-seq)&lt;/li&gt;
&lt;li&gt;Building new sequencing-based assays or new measurement modalities&lt;/li&gt;
&lt;li&gt;Molecular engineering (e.g. protein design and engineering)&lt;/li&gt;
&lt;li&gt;Mammalian synthetic biology (e.g. genetic circuit design)&lt;/li&gt;
&lt;li&gt;High-throughput library design and screening in mammalian cells&lt;/li&gt;
&lt;li&gt;Immune cell biology or engineering&lt;/li&gt;
&lt;li&gt;Immune receptor biology and profiling&lt;/li&gt;
&lt;li&gt;Neurobiology&lt;/li&gt;
&lt;li&gt;EVs, VLPs, or related nanoparticle systems&lt;/li&gt;
&lt;li&gt;In vivo models (e.g. mouse)&lt;/li&gt;
&lt;li&gt;Expertise in analysis of high-dimensional datasets (e.g. single-cell transcriptomics, spatial transcriptomics, pooled screening, using Python or R)&lt;/li&gt;
&lt;li&gt;Strong quantitative mindset&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;How to Apply&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Please submit:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;CV&lt;/li&gt;
&lt;li&gt;Brief cover letter describing your research interests, what kinds of projects you’re excited to lead, and why the Horns Lab is a fit. Please be sure to include contact information for 3+ references.&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://urldefense.proofpoint.com/v2/url?u=https-3A__ishajainlab.com_&amp;amp;d=DwMF-g&amp;amp;c=iORugZls2LlYyCAZRB3XLg&amp;amp;r=vNfva3Zcxin30zKAYt_noLb6dTqLO9YBIU9maXLKVgc&amp;amp;m=b7Q1OMvGii23FwRK-OoLUQBCXtY-Iv2b3lg6TRHv7n0&amp;amp;s=4LclCVUYC_syLsZYmGpVfdJTbpdN6zNlyn-sI3wu3Vk&amp;amp;e=&quot; target=&quot;_blank&quot;&gt;The Jain Lab&lt;/a&gt; is looking for motivated, hard-working and curious applicants. At a high level, we study how organisms interact with their environments – how “what we breathe” and “what we eat” affects our metabolism and disease progression. More specifically, we are focused on oxygen and vitamin/cofactor metabolism. We recently discovered that chronic hypoxia (equivalent to living in the mountains of Peru or Nepal) can serve as a therapy for mitochondrial disease. This approach is currently in clinical trials. This work has inspired a broader set of research directions ranging from fundamental biochemistry to animal physiology.&lt;/p&gt;
&lt;p&gt;The questions we ask:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;How do cells and organisms sense oxygen or vitamin levels? Are there novel oxygen sensors and vitamin sensors to be found?&lt;/li&gt;
&lt;li&gt;How does the body adapt to variations in oxygen levels? Or vitamin levels?&lt;/li&gt;
&lt;li&gt;When the supply and demand of oxygen or vitamins becomes mismatched, how does this contribute to disease?&lt;/li&gt;
&lt;li&gt;Can we “turn the oxygen and vitamin dials” as creative new therapies?&lt;/li&gt;
&lt;li&gt;What is the most practical form of turning these concepts into translatable therapies?&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;The approach we take: CRISPR screens, metabolomics, classical biochemistry/molecular biology, animal physiology and beyond.&lt;/p&gt;
&lt;p&gt;Post-docs will be encouraged to lead independent projects resulting in high impact publications, present at conferences and prepare for long-term careers in academia or industry.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are extremely curious and self-motivated to push the boundaries of biomedical research.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adapt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited by solving puzzles that have a translational impact.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Find new functions for enzymes or cofactors (vitamins)&lt;/li&gt;
&lt;li&gt;Contribute to our molecular understanding of how key metabolites are sensed by the body.&lt;/li&gt;
&lt;li&gt;Develop novel therapeutic strategies for nutrient-based therapies.&lt;/li&gt;
&lt;li&gt;Collaborate with post-docs and students to understand how enzymes and metabolites interact for key biochemical functions.&lt;/li&gt;
&lt;li&gt;Publish, present, and represent that lab in journals and conferences.&lt;/li&gt;
&lt;li&gt;Present at lab meetings, and participate in Arc-wide activities (seminars, symposiums, etc).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in metabolism, animal physiology, molecular biology, biochemistry, genomics, or related field&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Funding:&lt;/strong&gt;&amp;nbsp;Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Technology:&lt;/strong&gt;&amp;nbsp;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Support:&lt;/strong&gt;&amp;nbsp;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;&lt;strong&gt;Culture:&lt;/strong&gt;&amp;nbsp;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About the Position&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;We are seeking an exceptional computational postdoctoral fellow to join the Konermann and Goodarzi laboratories at the Arc Institute. This is a unique opportunity to work at the intersection of AI/ML, functional genomics, precision medicine, and single cell multiomics to develop and apply cutting-edge machine learning tools for understanding causal drivers of complex biological systems.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;In this joint position, you will contribute to developing broadly applicable computational frameworks for integrating multi-omics data, building predictive models of cellular behavior, and scaling phenotypic discovery in disease-relevant contexts, such as Alzheimer’s disease. Your work will leverage Arc’s state-of-the-art experimental platforms and collaborative environment.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;You are passionate about using machine learning and computational approaches to tackle challenging problems in human biology and disease.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;You are excited to develop novel computational methods and frameworks that enable biological discovery at scale.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;You are creative and eager to move with the fast-paced nature of modern AI/ML, and to explore new approaches beyond traditional methods.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;You enjoy working across disciplinary boundaries and integrating diverse data types.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;You work efficiently and write clean, well-documented code. You value reproducibility and good software engineering practices.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;You thrive in a fast-paced, collaborative environment where you can drive multiple projects forward in parallel.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;In This Position, You Will&lt;/strong&gt;&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Develop and apply AI/ML frameworks for modeling multi-omics datasets, with emphasis on scalable approaches for phenotypic screening and disease modeling.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Design and implement causal machine learning methods for predicting cellular states, drug responses, and disease phenotypes from genomic data.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Collaborate closely with experimental teams to design studies, optimize protocols, and integrate computational and experimental workflows.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Present research findings at internal meetings, seminars, and external conferences.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Mentor junior researchers, graduate students, and contribute to Arc’s collaborative scientific culture.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Publish high-impact research in leading scientific journals.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;PhD in Machine Learning, Computational Biology, Bioinformatics, Computer Science, Statistics, Bioengineering, or a related quantitative field.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Strong publication record demonstrating expertise in computational analysis of genomics data, particularly single-cell technologies.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Extensive experience with Python, machine learning frameworks, and distributed training, including active and well-maintained projects on public repositories.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Experience with machine learning and statistical modeling, particularly applied to biological data.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Strong understanding of molecular biology, with ability to design analyses that directly address biological questions.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Proven ability to work independently and collaboratively in interdisciplinary teams.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Excellent written and oral communication skills, with demonstrated ability to present complex computational work to diverse audiences.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Track record of completing projects and publishing results in peer-reviewed journals.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Experience with pooled screening technologies (CRISPR screens, perturbation screens, drug screens) and associated computational modeling.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Experience with multi-omics data integration and analysis.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Experience with cloud computing and scalable data analysis workflows.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Contributions to open-source software or publicly available computational tools.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Experience with spatial transcriptomics or other emerging single-cell technologies.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support: &lt;/strong&gt;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Postdoctoral Fellow with expertise in human immunology, neurobiology, or neuroimmunology to join the &lt;a href=&quot;https://arcinstitute.org/labs/pluvinagelab&quot;&gt;Pluvinage Lab&lt;/a&gt; at the Arc Institute. Our goal is to improve the lives of patients with neurological diseases by exploring undiagnosed autoimmunity in rare mystery cases and common neurodegenerative conditions alike.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;The questions we ask:&lt;/em&gt;&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;How do autoantibodies regulate cognition?&lt;/li&gt;
&lt;li&gt;What is the source, target, and mechanism of pathogenic autoantibodies in neurological disease?&lt;/li&gt;
&lt;li&gt;How can we eliminate pathogenic autoantibodies while leaving the rest of the immune system intact?&lt;/li&gt;
&lt;li&gt;How does comorbid autoimmunity contribute to cognitive decline in neurodegeneration?&lt;/li&gt;
&lt;li&gt;Are there protective autoantibodies that promote cognitive resilience in healthy brain aging?&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;em&gt;The approaches we take:&lt;/em&gt; discovery-driven projects starting with human samples (cerebrospinal fluid, PBMCs, brain tissue) from curated cohorts of patients with neurological diseases, CRISPR screens, phage display, immune repertoire sequencing&lt;/p&gt;
&lt;p&gt;Postdocs will be encouraged to lead independent projects resulting in high impact publications, present at conferences, and prepare for long-term careers in academia or industry. Clinical residents or fellows interested in physician-scientist pathways are encouraged to apply.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You have a strong foundation in human immunology, neurobiology, or neuroimmunology and are eager to apply this expertise to translational questions in neurological disease.&lt;/li&gt;
&lt;li&gt;You are extremely curious and self-motivated.&lt;/li&gt;
&lt;li&gt;You thrive in a fast-paced environment while conducting rigorous and impactful research.&lt;/li&gt;
&lt;li&gt;You are intellectually independent and are able to design new research directions and projects (with input from your PI).&lt;/li&gt;
&lt;li&gt;You are eager to learn and adopt new techniques.&lt;/li&gt;
&lt;li&gt;You are excited by solving puzzles that have a translational impact and/or creating new therapeutic approaches.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Conduct High-Impact Research: &lt;/strong&gt;Design, execute, and analyze experiments, taking ownership of a research project within the lab&#39;s scientific focus, with guidance from the PI and increasing independence as you develop expertise&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Develop as a Future Scientific Leader: &lt;/strong&gt;Publish first-author papers in high-impact journals, present your work at national and international conferences, and build a network of collaborators across the Arc Institute and beyond&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Foster Scientific Excellence:&amp;nbsp;&lt;/strong&gt;Mentor and train research associates, technicians, and students, engage in Arc-wide activities (seminars, symposia, journal clubs); contribute to a collaborative, inclusive research environment; keep rigorous experimental records and documentation; contribute to lab operations, including equipment maintenance and protocol development&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Doctorate (MD, PhD, MD/PhD, or equivalent) in immunology, neuroimmunology, neuroscience, genetics, or a related field&lt;/li&gt;
&lt;li&gt;Demonstrated expertise in human immunology or neurobiology, with a strong understanding of immune–nervous system interactions&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Hands-on experience with pooled genome-scale CRISPR screening&lt;/li&gt;
&lt;li&gt;Proficiency in single-cell immune repertoire sequencing&lt;/li&gt;
&lt;li&gt;Experience working with primary human samples (CSF, PBMCs, or tissue)&lt;/li&gt;
&lt;li&gt;Familiarity with computational analysis pipelines for high-dimensional immunological or single-cell data&lt;/li&gt;
&lt;li&gt;Track record of first-author publications in immunology, neuroscience, or related fields&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;
&lt;div class=&quot;job__description body&quot;&gt;
&lt;div&gt;
&lt;p&gt;The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Research Associate I to join the &lt;a href=&quot;https://arcinstitute.org/labs/arcelab&quot; target=&quot;_blank&quot;&gt;Arce Lab&lt;/a&gt; at the Arc Institute. In this role you will support ongoing research in the lab through experimentation and organizational contributions. You will work closely with the PI to pursue scientific questions about the immune system in an effort to better understand and treat immune mediated diseases. As you progress in the role, you will have the opportunity to independently lead sub-projects under the guidance of other lab members. This position is ideal for someone seeking hands-on experience with biomedical research in a fast paced environment.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are a self-motivated individual with a strong work ethic.&lt;/li&gt;
&lt;li&gt;You pride yourself on the quality of your work and avoid taking shortcuts that may limit outcomes.&lt;/li&gt;
&lt;li&gt;You are excited by the opportunity to discover new biology and learn something new each day.&lt;/li&gt;
&lt;li&gt;Helping out a colleague gives you self-gratification.&lt;/li&gt;
&lt;li&gt;You take initiative to resolve problems as they arise and are motivated by challenges and opportunities to grow.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Support a diverse range of experiments through general reagent maintenance and sample processing&lt;/li&gt;
&lt;li&gt;Help maintain lab organization and implement process improvements to enhance efficiency and safety&lt;/li&gt;
&lt;li&gt;Perform mammalian cell culture, including cell isolation from human blood samples&lt;/li&gt;
&lt;li&gt;Execute CRISPR gene editing experiments in an arrayed and pooled screening format using lentiviral and mRNA delivery&lt;/li&gt;
&lt;li&gt;Contribute to molecular biology and genomic workflows, including plasmid construction, PCR, western blots, DNA/RNA isolation, and sequencing library preparation&lt;/li&gt;
&lt;li&gt;Write and update standard operating procedures for lab protocols and processes as you gain expertise&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor&#39;s degree or equivalent experience in Biology, Molecular Biology, Biochemistry or related field&lt;/li&gt;
&lt;li&gt;1-2 years of laboratory experience (academic or industry setting)&lt;/li&gt;
&lt;li&gt;Familiarity with standard molecular biology techniques&lt;/li&gt;
&lt;li&gt;Competent multitasker with diligent note taking skills&lt;/li&gt;
&lt;li&gt;Proficiency with basic computer skills, including data entry, spreadsheets, and document preparation.&lt;/li&gt;
&lt;li&gt;Comfortable with lab relevant mathematics including dilution calculations and conversions&lt;/li&gt;
&lt;li&gt;Effective communicator and team player&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experienced with mammalian tissue culture&lt;/li&gt;
&lt;li&gt;Experience with RNA and DNA isolation and downstream assays&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The hourly rate for this position is $29.00. This amount does not include benefits or other forms of compensation.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Research Associate II to join the &lt;a href=&quot;https://arcinstitute.org/labs/konermannlab&quot;&gt;Konermann Laboratory&lt;/a&gt; at the Arc Institute.You will collaborate closely with experienced scientists to advance in vitro and in vivo projects focused on understanding brain development.&lt;/p&gt;
&lt;p&gt;This project builds on previous work in genome-scale CRISPR screening (Konermann et al., 2015; Biering et al., 2021; Wei et al., 2023) and aims at combining modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function. The ideal candidate will have experience in molecular biology, single cell RNA sequencing pipelines, in vitro and in vivo work. This position offers an excellent opportunity for candidates considering PhD programs, as you will participate in all stages of a research project under the guidance of experienced scientists.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are detail-oriented. You are careful and diligent about good documentation practices, good lab practices, and overall obsessed with keeping things organized.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort and you pride yourself in taking the initiative to help out.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a problem solver. Science isn’t perfect and it’s common for you to come across issues you need to troubleshoot. You demonstrate patience and confidence when solving complex technical challenges in the laboratory.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;In this position, you will:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Collaborate closely with senior scientists and RAs in the laboratory to conduct high-throughput CRISPR experiments&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Utilize a wide array of high-throughput molecular biology techniques, such as Gibson and Golden gate assembly, DNA/RNA isolation, cDNA synthesis, qPCR/dPCR, and more&lt;/li&gt;
&lt;li&gt;Independently conduct NGS library prep methods (single cell, bulk: long and short read).&lt;/li&gt;
&lt;li&gt;Assist with research planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS with 2+ years of relevant experience or MS in molecular biology, neuroscience, or another relevant field. Relevant experience includes independent lab work during undergraduate studies. Strong hands-on experience with molecular biology (cloning and NGS) required.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Detail-oriented with excellent organizational and time management skills.&lt;/li&gt;
&lt;li&gt;Outstanding critical thinking and problem-solving skills.&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills.&lt;/li&gt;
&lt;li&gt;Be both a strong individual contributor as well as a collaborative team member.&lt;/li&gt;
&lt;li&gt;Ability to work some weekends as needed (days off can be swapped for weekdays).&lt;/li&gt;
&lt;li&gt;Highly motivated, curious, and a team player&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Skills&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with human stem cell work and/or in vivo mouse work is preferred but not required for the role.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience with computational skills including scRNA-seq analysis is desirable.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary for this position is $75,900. This amount does not include benefits or other forms of compensation.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Research Associate I to join the &lt;a href=&quot;https://arcinstitute.org/labs/konermannlab&quot; target=&quot;_blank&quot;&gt;Konermann Laboratory&lt;/a&gt; at the Arc Institute. In this position, you will provide essential laboratory support while gaining comprehensive training in lab operations, management, and scientific best practices. You will work closely with our lab manager to support daily operations, maintain high standards of safety and organization, and assist with ongoing research activities. This position is ideal for someone seeking hands-on experience in laboratory operations while contributing to cutting-edge scientific research.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are naturally proactive with a strong work ethic. You don&#39;t wait to be told what needs to be done—you anticipate needs, take initiative, and take pride in maintaining organized, efficient lab spaces. You understand that excellent research depends on meticulous attention to detail and consistent execution.&lt;/li&gt;
&lt;li&gt;You have a natural affinity for process improvement and optimization. You&#39;re constantly thinking about how things can be done better, faster, or more efficiently. You enjoy analyzing workflows, identifying bottlenecks, and implementing solutions that benefit the entire team.&lt;/li&gt;
&lt;li&gt;You are collaborative and reliable. You thrive in team environments, take initiative to support others, and can be counted on to follow through on commitments while maintaining excellent communication about priorities and challenges.&lt;/li&gt;
&lt;li&gt;You are motivated by growth and continuous learning. You see this role as an opportunity to develop both technical and operational skills, and you&#39;re committed to contributing to lab efficiency and excellence.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Support lab stock management including reagent and supply inventory, ordering and receiving, and preparation of common solutions, with increasing independence as you develop familiarity with lab operations&lt;/li&gt;
&lt;li&gt;Help maintain lab organization and implement process improvements to enhance efficiency and safety&lt;/li&gt;
&lt;li&gt;Perform mammalian and stem cell culture, including cell maintenance, passaging, transfection, virus preparation, differentiation protocols, and co-culture systems, beginning with close guidance and progressing to autonomous execution&lt;/li&gt;
&lt;li&gt;Contribute to molecular biology and genomics workflows, including plasmid construction, PCR, qPCR, gel electrophoresis, DNA/RNA isolation, and sequencing preparation&lt;/li&gt;
&lt;li&gt;Write and update standard operating procedures for lab protocols and processes as you gain expertise&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor&#39;s degree or equivalent experience in Biology, Molecular Biology, Biochemistry or related field&lt;/li&gt;
&lt;li&gt;1-2 years of laboratory experience (academic or industry setting)&lt;/li&gt;
&lt;li&gt;Familiarity with standard molecular biology techniques (such as cloning, PCR, qPCR, gel electrophoresis, and DNA/RNA isolation) and mammalian cell culture; hands-on experience preferred but not required.&lt;/li&gt;
&lt;li&gt;Proficiency with basic computer skills, including data entry, spreadsheets, and document preparation.&lt;/li&gt;
&lt;li&gt;Effective organizational, communication, and collaborative skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The hourly rate for this position is $29.00. This amount does not include benefits or other forms of compensation.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support: &lt;/strong&gt;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Scientist to join the &lt;a href=&quot;https://arcinstitute.org/labs/hornslab&quot; target=&quot;_blank&quot;&gt;Horns Lab&lt;/a&gt; at the Arc Institute. In this position, you will lead the development of a novel platform for mapping human antibody specificities at scale. You will play a critical role in building, optimizing, and applying a system for high-throughput identification of antigen-specific B cells and their antibody sequences through single-cell sequencing. Your work will directly impact our understanding of human immunity and the discovery of new antibodies.&lt;/p&gt;
&lt;p&gt;The successful candidate will develop and scale this antibody discovery platform within the Horns lab at the Arc Institute. This work will initially focus on optimizing antigen-specific B cell isolation, establishing single-cell sequencing readouts, and scaling to multiplexed screens. In the longer term, this platform will be applied to comprehensively profile human immune repertoires for understanding human immunology in health and disease.&lt;/p&gt;
&lt;p&gt;The candidate will collaborate with other members of Arc’s labs and Technology Centers in a dynamic environment to drive scientific discoveries, including groups within Arc Institute who are leaders in RNA biology, single-cell genomics, and AI/ML. The ideal candidate would have a passion for cutting-edge technology development and a proven track record of working in an interdisciplinary environment and turning concepts into reliable methods and results. This is an excellent opportunity for an ambitious self-starter who is motivated to apply his/her skills to diverse projects and enjoys working in a collaborative, fast-paced team environment.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and understanding human immunity through the lens of new technology.&lt;/li&gt;
&lt;li&gt;You are excited to build new platforms for antibody discovery and immune repertoire analysis.&lt;/li&gt;
&lt;li&gt;You are creative and eager to explore new approaches beyond the techniques you are familiar with. You enjoy stepping out of your comfort zone to learn new things and develop new experimental approaches.&lt;/li&gt;
&lt;li&gt;You work fast, yet are diligent and detail-oriented. You are good at troubleshooting. You are careful about good documentation practices and keeping things organized while moving at a rapid pace.&lt;/li&gt;
&lt;li&gt;You excel at organization, time management, and task prioritization, and enjoy driving multiple projects in parallel.&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to help.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and optimize a platform for antigen-specific B cell labeling, sorting, and single-cell sequencing.&lt;/li&gt;
&lt;li&gt;Design and execute validation experiments, including specificity testing and antibody cloning and binding confirmation.&lt;/li&gt;
&lt;li&gt;Scale the platform to multiplexed antigen libraries for immune repertoire profiling.&lt;/li&gt;
&lt;li&gt;Analyze single-cell sequencing data computationally, including developing analysis pipelines.&lt;/li&gt;
&lt;li&gt;Apply these technologies to answer questions in human immunology.&lt;/li&gt;
&lt;li&gt;Embrace the opportunity to creatively collaborate with Technology Centers and other laboratories.&lt;/li&gt;
&lt;li&gt;Maintain accurate and detailed records of experimental protocols, results, and conclusions.&lt;/li&gt;
&lt;li&gt;Present key research findings at internal meetings and seminars, and external conferences.&lt;/li&gt;
&lt;li&gt;Provide guidance and mentorship to Research Associates.&lt;/li&gt;
&lt;li&gt;Stay updated on advancements in the field of single-cell genomics, antibody biology, and immune repertoire analysis by reading the literature and attending conferences.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in immunology, molecular biology, genomics, bioengineering, or a related field with 0-5 years of relevant post-PhD experience in either academia or industry.&lt;/li&gt;
&lt;li&gt;Deep experience with single-cell sequencing technologies for immune profiling (e.g. 10X Genomics VDJ workflows).&lt;/li&gt;
&lt;li&gt;Demonstrated track record of developing or adapting sequencing-based assays, with strong troubleshooting skills.&lt;/li&gt;
&lt;li&gt;Strong background in antibody biology, B cell immunology, or adaptive immune repertoire analysis.&lt;/li&gt;
&lt;li&gt;Proficiency in flow cytometry, including multi-parameter panel design, optimization, and cell sorting.&lt;/li&gt;
&lt;li&gt;Experience with antigen-binding characterization assays (e.g. ELISA, SPR, BLI).&lt;/li&gt;
&lt;li&gt;Proven ability to analyze large and complex sequencing data sets using Python, R, or similar tools.&lt;/li&gt;
&lt;li&gt;Experience with mammalian cell culture and standard molecular biology techniques (cloning, construct design).&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with antigen-barcoded B cell sequencing approaches (e.g. LIBRA-seq, CITE-seq) is a plus.&lt;/li&gt;
&lt;li&gt;Experience with antigen-specific cell sorting using labeled antigen probes (e.g. tetramer staining) is a plus.&lt;/li&gt;
&lt;li&gt;Experience with human primary immune cell isolation and culture is a plus.&lt;/li&gt;
&lt;li&gt;Experience with library design, pooled cloning, or high-throughput screening approaches is a plus.&lt;/li&gt;
&lt;li&gt;Experience with protein biochemistry (expression, purification) is a plus.&lt;/li&gt;
&lt;li&gt;Experience with machine learning approaches for sequence-function prediction is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $121,250 to $159,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 300 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Scientist with a strong background in cellular engineering and stem cell biology to join the Molecular Engineering team within the Genome Engineering Technology Center at the Arc Institute. In this role, you will design, generate, and characterize engineered human pluripotent stem cell (hPSC) lines for arrayed genetic perturbation screens in complex organoid models used to recapitulate and probe human genetics of neurodegenerative disorders. Examples of engineering projects include developing optimized effector systems for gene knockdown and activation that function robustly throughout differentiation, introducing rare coding variants to model disease-associated mutations, and implementing novel genome engineering technologies to expand perturbation capabilities. Through this work, you will play a critical role in the Institute&#39;s Alzheimer&#39;s Disease Initiative, an ambitious cross-functional effort aimed at identifying and drugging rational therapeutic targets to combat devastating neurodegenerative disorders.&lt;/p&gt;
&lt;p&gt;This position is highly collaborative and the candidate will have an unique opportunity to interface with pioneering labs that have developed the fundamental toolbox for genome engineering and functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and excited about answering questions related to molecular design, genome engineering technology development, and complex human diseases.&lt;/li&gt;
&lt;li&gt;You embrace challenges and often formulate creative solutions to develop new approaches and optimize existing tools to answer complex biological questions.&lt;/li&gt;
&lt;li&gt;You understand the importance of collaboration and thrive when working with a diverse team of scientists.&lt;/li&gt;
&lt;li&gt;You have a deep commitment to data quality while working in a fast-paced environment.&lt;/li&gt;
&lt;li&gt;Your organizational skills enable you to manage multiple concurrent projects, and your curiosity and creativity drive you to continuous learning and innovation.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and optimize engineered hPSC lines for arrayed genetic perturbation screens in complex organoid models, applying genome engineering strategies tailored to the desired edit and experimental goals.&lt;/li&gt;
&lt;li&gt;Design and implement systematic approaches to identify, benchmark, and optimize effector systems for gene knockdown and activation that function robustly throughout differentiation to disease-relevant cell types.&lt;/li&gt;
&lt;li&gt;Execute clonal isolation, expansion, and comprehensive characterization of engineered cell lines, applying and refining established quality control standards and assays to ensure functionality, stability, and reproducibility across multiple engineering approaches.&lt;/li&gt;
&lt;li&gt;Support the cross-functional execution of arrayed genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Serve as a key technical resource for cellular engineering of stem cells, partnering with researchers across Arc&#39;s Tech Centers and Core Labs to support a wide range of experimental applications and flexibly implement genome engineering approaches based on key biological questions and downstream requirements.&lt;/li&gt;
&lt;li&gt;Present findings at internal meetings and external conferences, and contribute to scientific publications.&lt;/li&gt;
&lt;li&gt;Stay updated on the latest developments in the fields of genome engineering, stem cell biology, and cellular engineering, actively seeking out opportunities for innovation and technology adoption.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Molecular Biology, Bioengineering, Genetics, or a related field.&lt;/li&gt;
&lt;li&gt;0-3 years of post-PhD research experience (industry or academia).&lt;/li&gt;
&lt;li&gt;Experience with genome and cell line engineering in stem cells, leveraging a range of genome engineering strategies (CRISPR-Cas9 knock-in, recombinase systems, base editing, prime editing, etc.) and performing comprehensive characterization including on-target validation, off-target assessment, and functional validation of edited cell lines.&lt;/li&gt;
&lt;li&gt;Experience with and enthusiasm for applying cutting-edge molecular tools to disease modeling and function-based screening, and implementing application-driven iterative, systematic technology maturation.&lt;/li&gt;
&lt;li&gt;A collaborative mindset and enthusiasm for mentoring and working within a cross-functional team.&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience differentiating hPSCs into neural or immune lineages; microglia differentiation experience highly desirable.&lt;/li&gt;
&lt;li&gt;Experience with transcriptional modulation systems (CRISPRi/a) for functional genomics screens, including effector optimization and performance benchmarking.&lt;/li&gt;
&lt;li&gt;Proficiency with computational tools for analyzing genomics data (Python, R, or similar).&lt;/li&gt;
&lt;li&gt;Experience with LIMS systems, ideally Benchling.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $121,250 - $159,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding:&lt;/strong&gt; Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support: &lt;/strong&gt;Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture: &lt;/strong&gt;We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/konermannlab&quot; target=&quot;_blank&quot;&gt;The Konermann Lab&lt;/a&gt; is seeking an exceptional Scientist to lead and collaborate on projects at the intersection of functional genomics and neurobiology. In this role, you will serve as experimental domain expert and apply state-of-the-art cell engineering, CRISPR screening and Perturb-seq technologies to advanced cellular model systems to decipher fundamental biological processes in neurons, microglia and other relevant cell types, provide molecular insights into the role of genetic risk factors in the progression of neurodegenerative diseases (with a focus on Alzheimer’s disease) as well as identify potential genetic modifiers to ameliorate disease progression.&lt;/p&gt;
&lt;p&gt;This position offers a unique chance for a highly motivated and curious researcher to collaborate with an interdisciplinary team of neuroscientists, computational biologists and in vivo scientists to connect novel molecular insights to potential translational applications.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about biological discovery and applying advanced molecular technologies to studying complex diseases and fundamental biological processes in challenging cell models.&lt;/li&gt;
&lt;li&gt;You thrive in a collaborative, multidisciplinary environment and enjoy working with both wet lab and computational scientists.&lt;/li&gt;
&lt;li&gt;You are a technologist at heart. You get excited about the potential of new tools (e.g. single-cell genomics, optical screening, multi-modal readouts) to answer questions that were previously impossible to ask.&lt;/li&gt;
&lt;li&gt;You are resilient. You understand that high-reward science involves risk. You approach troubleshooting with a critical mind and view obstacles as puzzles to be solved.&lt;/li&gt;
&lt;li&gt;You have a track record of independent experimental design, execution, troubleshooting and data analysis as well as successful completion of high-impact research projects as evidenced by your publications.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Collaborate with neurobiologists to implement functional genomics assays (arrayed and pooled) in human iPSC-derived neurons, microglia and multi-cellular stem cell derived brain models.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Serve as the technical expert in the design, execution, and analysis of functional genomic screens.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Develop and optimize novel screening assays and readouts suitable for neuronal/glial phenotypes.&lt;/li&gt;
&lt;li&gt;Perform cell culture, differentiation, and genome engineering of human ESC/iPSC and/or immune cell types.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Analyze multi-omic datasets and collaborate with computational scientists to derive insightful conclusions as well as generate new testable hypotheses.&lt;/li&gt;
&lt;li&gt;Present findings at internal meetings and external conferences, and contribute to the preparation of high-impact manuscripts.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Molecular Biology, Bioengineering, Genetics, or a related field.&lt;/li&gt;
&lt;li&gt;0-3 years of post-PhD research experience (industry or academia).&lt;/li&gt;
&lt;li&gt;Strong hands-on experience with mammalian cell culture and molecular biology techniques (cloning, library preparation, etc.).&lt;/li&gt;
&lt;li&gt;Deep expertise in functional genomics, specifically with CRISPR screening technologies (pooled or arrayed) including library design, library cloning, delivery of gene editors, screen design, screen execution and screen analysis.&lt;/li&gt;
&lt;li&gt;Strong critical thinking and data analysis skills, with the ability to troubleshoot complex experimental protocols.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills, with a track record of peer-reviewed publications or preprints.&lt;/li&gt;
&lt;li&gt;A collaborative mindset and enthusiasm for mentoring and working within a cross-functional team.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with single-cell RNA-seq and single-cell genomics technologies (e.g. 10X Genomics, Perturb-seq/CROP-seq or similar).&lt;/li&gt;
&lt;li&gt;Experience with live-cell microscopy, optical pooled screening and/or multiplexed proteomic readouts (e.g. CITE-seq, Olink or similar).&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience working with human iPSCs and differentiation procedures.&lt;/li&gt;
&lt;li&gt;Background in neurobiology/neurodegenerative disorders.&lt;/li&gt;
&lt;li&gt;Proficient in bioinformatics/data analysis of large datasets (using Python, R etc)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $121,250 to $159,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Scientist with a strong background in functional genomics and single-cell sequencing to join the Virtual Cell Initiative at Arc Institute. The initiative aims to create the first foundational model that makes accurate predictions of cellular states and their response to intervention. In this role, you will lead the generation of massive single-cell perturbation datasets across 50+ cancer cell lines to train Virtual Cell models.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;You will be responsible for the end-to-end experimental workflow—from mammalian cell culture and large-scale CRISPR screening to single-cell library preparation and sequencing. Beyond technical execution, this role requires a scientist with exceptional project management capabilities, proficient in organizing complex data streams and adhering to timelines. The successful candidate will thrive within our vibrant team science culture, collaborating daily with other wet lab scientists, automation engineers, and computational biologists. We believe that the most ambitious science is achieved together, and in this highly integrated role, you will bridge the gap between experimental biology and computational innovation.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about the intersection of high-throughput biology and AI/ML to advance human health.&lt;/li&gt;
&lt;li&gt;You enjoy working collaboratively with others and thrive in a fast-paced, dynamic, team science environment.&lt;/li&gt;
&lt;li&gt;You are committed to scientific rigor, generating high-quality data, and maintaining thorough documentation practices.&lt;/li&gt;
&lt;li&gt;You possess a process-oriented mindset, constantly seeking ways to optimize workflows for efficiency and scalability.&lt;/li&gt;
&lt;li&gt;You are diligent, detail-oriented, and excel at troubleshooting complex experimental pipelines.&lt;/li&gt;
&lt;li&gt;You excel at organization, time management, and task prioritization, and enjoy independently driving multiple projects in parallel.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Execute large &lt;em&gt;in vitro&lt;/em&gt; perturbation screens in diverse cell types to generate high quality single-cell perturbation datasets.&lt;/li&gt;
&lt;li&gt;Work with our interdisciplinary teams to further optimize functional genomics platforms and CRISPR technologies for large-scale data generation.&lt;/li&gt;
&lt;li&gt;Utilize project management systems to track progress and adhere to timelines, and document experimental data on ELN/LIMS in an organized manner.&lt;/li&gt;
&lt;li&gt;Interact cross-functionally with wet lab, computational, and machine learning teams to generate, analyze, and interpret data.&lt;/li&gt;
&lt;li&gt;Present key research findings at internal meetings and seminars, and external conferences.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Cell Biology, Molecular Biology, Genomics, or another relevant field.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;0-3 years of post-PhD experience in academia or industry.&lt;/li&gt;
&lt;li&gt;Extensive experience with large-scale pooled CRISPR screening, preferably with scRNA-seq readouts (e.g. Perturb-seq, CROP-seq).&lt;/li&gt;
&lt;li&gt;Expertise in mammalian cell culture and ability to manage multiple cell lines simultaneously.&lt;/li&gt;
&lt;li&gt;Experience in multi-color flow cytometry.&lt;/li&gt;
&lt;li&gt;Experience with mammalian cell line engineering using transfection, lentivirus production and transduction, and other common approaches.&lt;/li&gt;
&lt;li&gt;Experience with different molecular biology techniques (cloning, PCR, etc).&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work both independently and in a highly collaborative multidisciplinary environment.&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to independently plan, execute, and deliver results on time. Experience with using various project management systems, ELN and LIMS (e.g. Asana, Benchling).&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Hands-on experience with downstream genomics protocols, especially scRNA-seq (preferably 10X Genomics workflows).&lt;/li&gt;
&lt;li&gt;Experience designing and cloning large pooled CRISPR sgRNA libraries.&lt;/li&gt;
&lt;li&gt;Experience optimizing different CRISPR-Cas9 effector systems, such as CRISPRi and CRISPRa, including vector design and delivery.&lt;/li&gt;
&lt;li&gt;Experience performing FACS-based cell sorting.&lt;/li&gt;
&lt;li&gt;Ability to analyze large datasets using Python, R, or similar tools.&lt;/li&gt;
&lt;li&gt;Familiarity with different NGS technologies (Illumina, Ultima).&lt;/li&gt;
&lt;li&gt;Experience using automation to scale, streamline, and optimize large-scale experiments.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $121,250 - $159,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology: &lt;/strong&gt;Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://arcinstitute.org/labs/hsulab&quot;&gt;The Hsu Lab&lt;/a&gt; is seeking applications for a Scientist at the Arc Institute in Palo Alto, CA, focusing on the development and applications of novel genome engineering technologies. We recently discovered and developed Bridge Recombinases, which are naturally occurring RNA-guided DNA recombinases that can programmably insert, excise, and invert DNA (&lt;a href=&quot;https://www.nature.com/articles/s41586-024-07552-4&quot;&gt;Nature, 2024&lt;/a&gt; and &lt;a href=&quot;https://www.science.org/doi/10.1126/science.adz0276&quot;&gt;Science, 2025&lt;/a&gt;). The candidate will drive the next phase of Bridge Recombinase evolution. Building on our work establishing IS110 and ISCro4 as programmable tools, you will lead efforts to engineer bridge RNAs and recombinases for megabase-scale genome modifications, therapeutic gene circuit integration, and scarless disease correction. You will tackle critical challenges in RNA structural design, protein evolution, and off-target minimization to bridge the gap between basic discovery and clinical application. To achieve this, you will work in collaboration with biochemists, structural biologists and computational scientists in the lab, with the ultimate goal of enabling therapeutic applications in human cells and aiding genome design.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are driven by science. The world of science is filled with so many unanswered questions and the opportunity to address these questions brings you purpose.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a collaborator. You love working with people of different backgrounds and brainstorming ideas on how these questions can be addressed.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are intellectually independent and self-motivated to push the boundaries of novel technologies.&lt;/li&gt;
&lt;li&gt;You are an optimizer. In research, there’s always a race against the clock. You care deeply about making every step of the way as close to perfect as possible but also as quick and efficient as possible.&lt;/li&gt;
&lt;li&gt;You build tools. As much as you love answering specific scientific questions, you also love creating technology and platforms that are scalable and useful in many different scientific application areas.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead one or multiple scientific projects in molecular technology development including planning, execution, analysis of experiments.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Collaborate closely with the PIs on planning and executing scientific research projects.&lt;/li&gt;
&lt;li&gt;Keep up-to-date on advances in the field by reading the literature and attending key conferences.&lt;/li&gt;
&lt;li&gt;Mentor Research Associates and/or work with graduate students and other scientists in the lab&lt;/li&gt;
&lt;li&gt;Develop and provide training to lab personnel as needed, develop standardized protocols for the labs.&lt;/li&gt;
&lt;li&gt;Publish preprints and journal articles; present findings at conferences&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in a relevant life sciences or engineering field&lt;/li&gt;
&lt;li&gt;Experience with different molecular biology assays and techniques, including high-throughput cloning strategies (e.g., Golden Gate, Gibson) and library generation&lt;/li&gt;
&lt;li&gt;Mammalian cell culture experience&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience in protein engineering, directed evolution (e.g., PACE, DMS), or rational protein design&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Prior experience in developing genome engineering technologies (CRISPR, recombinases, transposases, etc.) preferred&lt;/li&gt;
&lt;li&gt;Strong written and verbal communication skills&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience and enthusiasm for mentoring research trainees, including graduate students and RAs&lt;/li&gt;
&lt;li&gt;The successful candidate will be an ambitious self-starter, an innovative and meticulous researcher, and enjoy working in a collaborative and fast-paced team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $121,250 to $159,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for an exceptional experienced machine learning scientist specializing in developing large-scale models. The ideal candidate will play a key role in constructing advanced machine learning models to predict cell state response to perturbations as part of Arc’s Virtual Cell Initiative.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about machine learning with real-world applications and scientific impact.&lt;/li&gt;
&lt;li&gt;You want to develop cutting-edge, biology-inspired, multimodal machine learning models.&lt;/li&gt;
&lt;li&gt;You are excited about collaborating with a multidisciplinary team of experimental biologists and machine learning engineers at Arc.&lt;/li&gt;
&lt;li&gt;You are a strong communicator, capable of translating complex technical concepts to non-technical audiences across disciplines&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a continuous learner&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Build state-of-the-art AI models for understanding how cells respond to perturbation, in collaboration with other ML researchers, engineers and experimental scientists at Arc.&lt;/li&gt;
&lt;li&gt;Guide interdisciplinary teams towards successful delivery of reliable and robust machine learning models with clear scientific impact.&lt;/li&gt;
&lt;li&gt;Stay up-to-date with the latest advancements in machine learning for computational biology, scope out new areas of work and ensure the models built at Arc remain state-of-the-art.&lt;/li&gt;
&lt;li&gt;Develop strategies for both training of models as well as the large-scale generation of new experimental data to train those models, as part of Arc’s Virtual Cell Initiative.&lt;/li&gt;
&lt;li&gt;Publish findings through journal publications, white papers, and presentations.&lt;/li&gt;
&lt;li&gt;Commit to a collaborative and inclusive team environment, sharing expertise, mentoring others and fostering collaborations.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computer Science, Computational Biology, Bioinformatics, Machine Learning, or a related field.&lt;/li&gt;
&lt;li&gt;Minimum of 3 years of experience post-PhD in building machine learning models for large datasets.&lt;/li&gt;
&lt;li&gt;Strong research background with contributions to machine learning conferences (e.g., NeurIPS, ICLR, ICML) or interdisciplinary scientific journals (e.g., Nature, Nature Methods, Science).&lt;/li&gt;
&lt;li&gt;Well-versed in machine learning frameworks such as PyTorch.&lt;/li&gt;
&lt;li&gt;Excellent communication skills, both written and verbal, with a strong track record of publications.&lt;/li&gt;
&lt;li&gt;Proven track record of communicating and collaborating with domain experts and ML engineers.&lt;/li&gt;
&lt;li&gt;Motivated to work in a fast-paced, ambitious, multi-disciplinary, and highly collaborative research environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with training and scaling large-scale machine learning models.&lt;/li&gt;
&lt;li&gt;Strong foundation in software engineering with a proven ability to deliver machine learning products from research to production.&lt;/li&gt;
&lt;li&gt;Experience working with biological datasets including single-cell genomics, genomic sequences, bioimaging&lt;/li&gt;
&lt;li&gt;Demonstrated key contributions to the field of predictive modeling of cell states.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $235,000-$291,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding&lt;/strong&gt;: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology&lt;/strong&gt;: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support&lt;/strong&gt;: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture&lt;/strong&gt;: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Senior Research Associate to join the Functional Genomics team inside the Genome Engineering Technology Center at the Arc Institute. This position will directly support our efforts of high-throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi-omic readouts. You will play a critical role in the Virtual Cell Initiative, which aims to create the first foundational model that makes accurate predictions of cellular states and their response to intervention. You will also have the opportunity to partner closely with pioneering labs that have developed the fundamental toolbox for genome engineering and functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.&lt;/p&gt;
&lt;p&gt;The ideal candidate will have hands-on experience and proficient skills in mammalian cell culture, functional genomic screens and NGS library preparation, and familiarity with various other cellular and molecular techniques. They must also demonstrate the ability to independently execute and troubleshoot complex workflows and protocols with an outstanding attention to detail. This is an excellent opportunity for a highly motivated and curious researcher interested in leveraging cutting-edge functional genomic technologies to drive innovative scientific discoveries.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are highly motivated and passionate about applying cutting-edge functional genomics techniques to enable scientific discoveries.&lt;/li&gt;
&lt;li&gt;You are diligent, detail oriented, adaptable, and excels at troubleshooting.&lt;/li&gt;
&lt;li&gt;You are committed to generating high quality data and maintaining good documentation practices.&lt;/li&gt;
&lt;li&gt;You enjoy working collaboratively with others and thrive in a fast-paced, dynamic work environment.&lt;/li&gt;
&lt;li&gt;You respect the process and are comfortable carrying out the routine execution of tasks while identifying opportunities to troubleshoot and address bottlenecks.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Conduct routine mammalian cell culture, including cell line banking, expansion and manipulation.&lt;/li&gt;
&lt;li&gt;Contribute to the execution of large scale &lt;em&gt;in vitro &lt;/em&gt;perturbation screens and downstream sample preparation for NGS.&lt;/li&gt;
&lt;li&gt;Participate in other research efforts related to cellular model, technology and assay development.&lt;/li&gt;
&lt;li&gt;Execute tasks and experiments with a focus on efficiency and reproducibility, following already established SOPs and ensuring accurate and reliable record keeping and documentation in our ELN and LIMS system.&lt;/li&gt;
&lt;li&gt;Analyze and present data at internal meetings and seminars.&lt;/li&gt;
&lt;li&gt;Collaborate cross-functionally with other Tech Center teams at Arc.&lt;/li&gt;
&lt;li&gt;Contribute to lab organization and maintenance, including rotating in regular cleaning schedules and inventory management of supplies and reagents.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS or equivalent professional experience in cell biology, molecular biology, genetics or another relevant field.&lt;/li&gt;
&lt;li&gt;BS degree, 4+ years of relevant experience or with a MS degree, 2+ years of relevant postgraduate experience. Industry experience is desirable but not required.&lt;/li&gt;
&lt;li&gt;Proficiency in mammalian cell culture procedures and associated aseptic techniques, including direct experiences work with difficult cell types. Experience culturing stem cells is a plus.&lt;/li&gt;
&lt;li&gt;Hands-on experience executing pooled screens is a must.&lt;/li&gt;
&lt;li&gt;Experienced with different NGS workflows.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience and knowledge of various cellular, molecular and biochemical techniques such as viral production, qPCR, ELISA and western blotting.&lt;/li&gt;
&lt;li&gt;Experience in molecular cloning, preferably for large pooled screens.&lt;/li&gt;
&lt;li&gt;Attention to details with the ability to deliver high quality work in a consistent manner.&lt;/li&gt;
&lt;li&gt;The ability to independently execute experiments involving complex workflows, and troubleshoot technical problems.&lt;/li&gt;
&lt;li&gt;Strong oral and written communication skills.&lt;/li&gt;
&lt;li&gt;Flexibility to work some weekends as needed (days off can be swapped for weekdays).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Prior experience on single-cell RNA sequencing (scRNA-seq) is a strong plus.&lt;/li&gt;
&lt;li&gt;Multi-color flow cytometry and FACS.&lt;/li&gt;
&lt;li&gt;Prior experience differentiating stem cells.&lt;/li&gt;
&lt;li&gt;Experience with LIMS systems, ideally Benchling.&lt;/li&gt;
&lt;li&gt;Prior experience working with CRISPR-Cas9 or other genome engineering techniques.&lt;/li&gt;
&lt;li&gt;Adept at data analysis in an independent manner.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $87,000 - $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p class=&quot;p1&quot;&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul class=&quot;ul1&quot;&gt;
&lt;li class=&quot;li1&quot;&gt;Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li class=&quot;li1&quot;&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Senior Research Associate with a strong background in single-cell RNA-seq to join the Virtual Cell Initiative at Arc Institute. In this role, you will contribute to the generation of large-scale single-cell perturbation datasets across 50+ cancer cell lines to train Virtual Cell models to make accurate predictions of cellular state and their response to intervention.&lt;/p&gt;
&lt;p&gt;You will use your experience implementing single-cell genomics technologies to scale our workflows for generating high-quality scRNA-seq datasets and contribute to critical data generation for Arc’s Virtual Cell Initiative. As part of a highly collaborative team, you will have opportunities to build expertise in cell line engineering, mammalian cell culture, and CRISPR screening. This role is ideal for someone who is detail-oriented and motivated by optimizing experimental workflows. The successful candidate will have excellent time management and communication skills and will thrive within our vibrant and collaborative culture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about working at the intersection of high-throughput biology and AI/ML to advance human health.&lt;/li&gt;
&lt;li&gt;You are process-oriented and are motivated by optimizing workflows for efficiency and scalability.&lt;/li&gt;
&lt;li&gt;You thrive in a timeline-driven, dynamic, team science environment.&lt;/li&gt;
&lt;li&gt;You hold yourself to a high standard of rigor and consistency in your experimental work.&lt;/li&gt;
&lt;li&gt;You are detail-oriented and maintain thorough documentation practices.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Execute single cell genomics workflows, including sample processing, NGS library preparation, and QC.&lt;/li&gt;
&lt;li&gt;Support Arc’s Virtual Cell Initiative CRISPR screening efforts by working collaboratively to generate large&lt;em&gt; in vitro&lt;/em&gt; gene perturbation datasets across many cell contexts.&lt;/li&gt;
&lt;li&gt;Optimize and troubleshoot our single cell sequencing and CRISPR screening workflows to maximize data quality, diversity, and scalability.&lt;/li&gt;
&lt;li&gt;Streamline high throughput experiments by implementing automation solutions.&lt;/li&gt;
&lt;li&gt;Utilize project management systems to track progress and ELN/LIMS&amp;nbsp; systems to document experimental data.&lt;/li&gt;
&lt;li&gt;Communicate experimental progress and results at group and cross-functional meetings.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS + 4 years or MS + 2 years of professional experience in cellular biology, molecular biology, biochemistry, neuroscience, or another relevant field.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Expertise in running single cell RNA-seq workflows, including cell sample preparation, single cell capture, and library preparation. Experience with 10X Genomics technology is a plus.&lt;/li&gt;
&lt;li&gt;Hands-on experience with common molecular biology techniques, including PCR/qPCR/ddPCR, DNA and RNA purification, and nucleic acid QC and quantification (e.g., TapeStation, Qubit).&lt;/li&gt;
&lt;li&gt;Proficiency in aseptic technique for culturing mammalian cell lines.&lt;/li&gt;
&lt;li&gt;Strong attention to detail and ability to follow experimental protocols precisely.&lt;/li&gt;
&lt;li&gt;Experience using an ELN to document your work and track biological material. Familiarity with Benchling is a plus.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills and a collaborative mindset.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience working in an industry setting is desirable but not required.&lt;/li&gt;
&lt;li&gt;Experience implementing liquid handling solutions or automation for molecular biology workflows.&lt;/li&gt;
&lt;li&gt;Familiarity with performing large-scale pooled CRISPR screens.&lt;/li&gt;
&lt;li&gt;Proficiency in flow cytometry or cell sorting for single cell sample preparation.&lt;/li&gt;
&lt;li&gt;Experience with software for data analysis and visualization. Familiarity with analyzing data using Python, R, or another high-level programming language is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p class=&quot;p1&quot;&gt;The base salary range for this position is $87,000 - $114,250. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

Working at the Arc InstituteSolving hard science problems together

Ambition and vision

Curiosity coupled with pragmatic solutions

Collaboration

Compensation and benefits

Open roles

Core Facilities

Flow Cytometry Specialist

Palo Alto, CA

Core Laboratories

Postdoctoral Researcher, Jain Lab

Palo Alto, CA

Postdoctoral Researcher, Gilbert Lab

Palo Alto, CA

Research Associate I, Konermann Lab

Palo Alto, CA

Postdoctoral Researcher, Pluvinage Lab

Palo Alto, CA

Scientist, Functional Genomics, Konermann Lab

Palo Alto, CA

Research Associate II, Konermann Lab

Palo Alto, CA

Postdoctoral Researcher, Horns Lab

Palo Alto, CA

Scientist, Genome Editing Technologies, Hsu Lab

Palo Alto, CA

Postdoctoral Researcher, Konermann & Goodarzi Labs

Palo Alto, CA

Scientist, Antibody Discovery, Horns Lab

Palo Alto, CA

Research Associate I, Arce Lab

Palo Alto, CA

Operations

FP&A Manager

Palo Alto, CA

Technology Centers

Director, Machine Learning, Alzheimer's Disease Initiative

Palo Alto, CA

Senior Machine Learning Research Scientist

Palo Alto, CA

Associate Director, Genomics Platform

Palo Alto, CA

Senior Research Associate, Functional Genomics

Palo Alto, CA

Director, Computational Biology

Palo Alto, CA

Scientist, Cell Engineering

Palo Alto, CA

Scientist, Functional Genomics, Virtual Cell Initiative

Palo Alto, CA

Senior Research Associate, Single Cell Screening

Palo Alto, CA

Working at the Arc Institute
Solving hard science problems together