Core Facilities

Palo Alto, CA

Research Associate II, Gilbert Lab

Scientist, Horns Lab

Core Laboratories

Faculty & Fellows

Operations

Machine Learning Research Scientist

Scientist, Single Cell Assay Development

Senior Director, Cellular Models Technology Center

Senior Scientist, In Vivo Functional Genomics - Neuroscience

Senior Scientist, In Vivo Functional Genomics - Technology Development

Senior Scientist, Molecular Engineering

Senior Scientist, Stem Cell Neural Model Development

Technology Centers

No Department

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for an exceptional machine learning scientist specializing in developing large-scale models. The ideal candidate will play a key role in constructing advanced machine learning models to predict cell state response to perturbations as part of Arc’s Virtual Cell Initiative.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about machine learning with real-world applications and scientific impact.&lt;/li&gt;
&lt;li&gt;You want to develop cutting-edge, biology-inspired, multimodal machine learning models.&lt;/li&gt;
&lt;li&gt;You are excited about collaborating with a multidisciplinary team of experimental biologists and machine learning engineers at Arc.&lt;/li&gt;
&lt;li&gt;You are a strong communicator, capable of translating complex technical concepts to non-technical audiences across disciplines&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a continuous learner&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Build state-of-the-art AI models for understanding how cells respond to perturbation, in collaboration with other ML researchers, engineers and experimental scientists at Arc.&lt;/li&gt;
&lt;li&gt;Stay up-to-date with the latest advancements in machine learning for computational biology and ensure the models built at Arc remain state-of-the-art.&lt;/li&gt;
&lt;li&gt;Guide both the training of models as well as the large-scale generation of new experimental data to train those models, as part of Arc’s Virtual Cell Initiative.&lt;/li&gt;
&lt;li&gt;Collaborate with experimental biologists to ensure that the developed models are grounded in biologically impactful use cases.&lt;/li&gt;
&lt;li&gt;Publish findings through journal publications, white papers, and presentations.&lt;/li&gt;
&lt;li&gt;Commit to a collaborative and inclusive team environment, sharing expertise, mentoring others and fostering collaborations.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computer Science, Computational Biology, Bioinformatics, Machine Learning, or a related field.&lt;/li&gt;
&lt;li&gt;Minimum of 3 years of experience in building machine learning models for large datasets.&lt;/li&gt;
&lt;li&gt;Well-versed in machine learning frameworks such as PyTorch.&lt;/li&gt;
&lt;li&gt;Excellent communication skills, both written and verbal, with a strong track record of publications.&lt;/li&gt;
&lt;li&gt;Ability to communicate and collaborate successfully with domain experts and ML engineers.&lt;/li&gt;
&lt;li&gt;Motivated to work in a fast-paced, ambitious, multi-disciplinary, and highly collaborative research environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Strong research background with contributions to machine learning conferences (e.g., NeurIPS, ICLR, ICML) or interdisciplinary scientific journals (e.g., Nature, Nature Methods, Science).&lt;/li&gt;
&lt;li&gt;Experience working with biological datasets including single-cell genomics, genomic sequences, bioimaging&lt;/li&gt;
&lt;li&gt;Software engineering experience&lt;/li&gt;
&lt;li&gt;Demonstrated key contributions to the field of predictive modeling of cell states.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $163,950 to $202,550. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

Headquarters - 3181 Porter Drive, Palo Alto, CA

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for a highly motivated, well-organized, and technically proficient Research Associate II to join the Gilbert laboratory at the Arc Institute. In this position, you will contribute to the development of new technologies for functional genomics and gain expertise in molecular biology, mammalian cell culture, and cell engineering. You will have the opportunity to work with scientists in single-cell genomics, computational biology, and CRISPR-Cas systems. The Research Associate will be expected to work independently and collaboratively with members of the Gilbert laboratory. A successful applicant will demonstrate attention to detail, an eagerness to learn new skills, and the ability to self-direct. Compensation will be competitive with industry jobs relative to experience level and background.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are excited about a broad range of scientific and research topics and have taken a variety of courses to explore your interests.&lt;/li&gt;
&lt;li&gt;You are organized and detail-oriented when planning and performing experimental tasks.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You think about scientific questions critically, pursuing a deep understanding of each experimental step.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You thrive in a team environment, working collaboratively at a fast pace.&lt;/li&gt;
&lt;li&gt;You enjoy exploring new technologies and how they enable large-scale multi-omic biological measurements.&lt;/li&gt;
&lt;li&gt;You explicitly wish to use this experience to gain entry into a PhD program and are able to provide a minimum 2-year commitment to build a portfolio of work to support you in that endeavor.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Utilize a wide array of molecular biology techniques, such as restriction enzyme cloning, Gibson Assembly, Golden Gate Assembly, gel electrophoresis, cDNA synthesis, PCR, qPCR, bacterial transformation, DNA &amp;amp; RNA purification, ELISA, and NGS sample preparation&lt;/li&gt;
&lt;li&gt;Gain experience in mammalian cell culture, flow cytometry, AAV &amp;amp; lentivirus production, cell engineering, and computational biology&lt;/li&gt;
&lt;li&gt;Assist with research planning, execution, analysis, troubleshooting, and data interpretation with support from the Gilbert laboratory&lt;/li&gt;
&lt;li&gt;Develop into a well-rounded researcher through reading applicable literature, taking ownership of experiments, and collaborating with Arc Scientists&lt;/li&gt;
&lt;li&gt;Maintain careful records, work independently, and communicate experimental results clearly&lt;/li&gt;
&lt;li&gt;Thrive in a fast-paced team environment&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Actively participate in journal club, lab meetings, and seminars through presentations and discussions&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS or equivalent professional experience in cell &amp;amp; molecular biology, biochemistry, bioengineering, or similar field.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;2+ years of relevant experience in an academic or industry setting (including independent lab work during your undergraduate studies).&lt;/li&gt;
&lt;li&gt;Hands-on experience with molecular biology techniques including qRT-PCR, PCR, DNA and RNA isolation, and DNA &amp;amp; RNA purification&lt;/li&gt;
&lt;li&gt;Familiarity with scientific software (Prism/FloJo) or programming languages (Python/R) for data analysis.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Display broad interest in scientific research, demonstrated through courses or research projects&lt;/li&gt;
&lt;li&gt;Must have excellent written and oral communication skills.&lt;/li&gt;
&lt;li&gt;Must have strong attention to detail and organization skills, as well as the ability to troubleshoot experiments independently.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Highly collaborative, team-oriented, Self-motivated and take ownership of projects.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The base salary for this position is $73,700. This amount does not include benefits or other forms of compensation.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Scientist to join the Horns laboratory at the Arc Institute. In this position, you will contribute to developing cutting-edge technology at the interface of synthetic biology and genomics, as well as harnessing this technology to understand complex diseases, such as cancer, autoimmunity, and neurodegeneration. You will play a critical role in creating new approaches to monitor the dynamics of cellular states using nucleic acid measurements, building upon our recent work on&amp;nbsp;&lt;a href=&quot;https://www.cell.com/cell/fulltext/S0092-8674(23)00689-X&quot;&gt;cellular RNA export technology&lt;/a&gt;. You will have the opportunity to partner closely with pioneering labs that have developed the fundamental toolbox for cellular RNA export, single-cell RNA sequencing, and genome engineering.&lt;/p&gt;
&lt;p&gt;The successful candidate will develop and apply cellular monitoring technologies within the Horns lab at the Arc Institute. This work will initially focus on creating novel approaches for monitoring dynamic cellular states and on using these approaches in mammalian model systems to discover fundamental biological principles and therapeutic strategies for cancer, immune, and neurodegenerative diseases. The successful candidate will collaborate with other members of Arc’s labs and Technology Centers in a dynamic environment to drive innovative scientific discoveries. The ideal candidate would have a passion for cutting-edge technology development and a proven track record of working in an interdisciplinary environment and turning concepts into reliable methods and results. This is an excellent opportunity for an ambitious self-starter who is motivated to apply his/her skills to diverse projects and enjoys working in a collaborative, fast-paced team environment.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and answering questions related to genomics technology, cellular states, complex human diseases, and synthetic biology.&lt;/li&gt;
&lt;li&gt;You are excited to develop new molecular tools to answer fundamental questions.&lt;/li&gt;
&lt;li&gt;You are creative and eager to explore new approaches beyond the techniques you are familiar with. You enjoy stepping out of your comfort zone to learn new things and develop new experimental approaches.&lt;/li&gt;
&lt;li&gt;You work fast, yet are diligent and detail-oriented. You are good at troubleshooting. You are careful about good documentation practices and keeping things organized while moving at a rapid pace.&lt;/li&gt;
&lt;li&gt;You excel at organization, time management, and task prioritization, and enjoy driving multiple projects in parallel.&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to help.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop technologies for monitoring cellular dynamics using cell engineering and nucleic acid measurements (e.g. NGS, in situ hybridization).&lt;/li&gt;
&lt;li&gt;Apply these technologies in mammalian model systems (e.g. stem cell cultures, 3D cultures, and animal models) to interrogate complex human diseases.&lt;/li&gt;
&lt;li&gt;Embrace the opportunity to creatively collaborate with Technology Centers and other laboratories.&lt;/li&gt;
&lt;li&gt;Maintain accurate and detailed records of experimental protocols, results, and conclusions.&lt;/li&gt;
&lt;li&gt;Present key research findings at internal meetings and seminars, and external conferences.&lt;/li&gt;
&lt;li&gt;Provide guidance and mentorship to Research Associates.&lt;/li&gt;
&lt;li&gt;Stay updated on advancements in the field of single-cell technology, genomics, and synthetic biology by reading the literature and attending conferences.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in molecular biology, biochemistry, genomics, bioengineering, or a related field with 0-5 years of relevant post-PhD experience in either academia or industry.&lt;/li&gt;
&lt;li&gt;Proven record in genomics, single-cell biology, or related method development publications.&lt;/li&gt;
&lt;li&gt;Deep expertise in molecular biology, focusing on NGS, single-cell sequencing (RNA, DNA, or epigenetics), or in situ nucleic acid measurement (e.g. FISH, spatial transcriptomics) assay development and workflows.&lt;/li&gt;
&lt;li&gt;Experience with mammalian cell culture, cell line engineering, and associated techniques for construct design, cloning, and characterization of genetically modified cells (flow cytometry, microscopy).&lt;/li&gt;
&lt;li&gt;Demonstrated success in developing and optimizing novel molecular biology assays with strong troubleshooting skills.&lt;/li&gt;
&lt;li&gt;Familiarity with current bioinformatic tools and ability to analyze large and complex sequencing data sets using Python, R, or similar tools.&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with mammalian synthetic biology is a plus.&lt;/li&gt;
&lt;li&gt;Experience with microscopy is a plus.&lt;/li&gt;
&lt;li&gt;Experience with virus or vesicle purification and characterization is a plus.&lt;/li&gt;
&lt;li&gt;Experience with animal handling, colony management, and surgery is a plus. Techniques of special interest: intraperitoneal, tail-vein, and retro-orbital injections, blood and tissue collection.&lt;/li&gt;
&lt;li&gt;Experience working with cancer models or immune or brain cells (HSCs, T cells, B cells, monocytes, neurons, glia) is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;
&lt;p&gt;The base salary range for this position is $121,500 to $134,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for a passionate scientist with a strong single cell and molecular assay development background to join our Multiomic Technology Development Center at Arc Institute. You will work closely with scientists and research associates in the technology centers and core investigator labs at Arc to unleash the potentials of single cell analysis tools for cutting edge neurodegenerative diseases and cancer research.&amp;nbsp; You will develop and apply high-throughput single cell multiomic readouts of mammalian genomes, transcriptomes and epigenomes to large-scale genetic and environmental perturbations. You will play a critical role in the Institute’s Virtual Cell Initiative, which aims to create the first foundational model that makes accurate predictions of cellular states and their responses to intervention, and ultimately to help identify rational therapeutic targets for devastating complex human diseases.&amp;nbsp;&amp;nbsp;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The ideal candidate would have a passion for cutting edge technology development and a proven track record of working in an interdisciplinary environment which leads to turning concepts into reliable methods and results. This is an excellent opportunity for a highly motivated and curious scientist interested in the intersection of basic discovery research and biotech goal-driven technology development.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and excited about answering questions related to single cell, genetic perturbations and complex human diseases.&lt;/li&gt;
&lt;li&gt;You are excited to develop novel molecular assays and tools to answer complex biological questions&lt;/li&gt;
&lt;li&gt;You are creative, curious and unafraid to try new methodologies of tackling problems beyond the technique/approaches you are familiar with.&lt;/li&gt;
&lt;li&gt;You understand the importance of collaboration and the opportunity to thrive when working with a diverse team of scientists&lt;/li&gt;
&lt;li&gt;You have a deep commitment to data quality, reproducibility, scalability while working in a fast-paced environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work with the principal research scientist to drive single-cell technology development projects from concept through development and application, and contribute to the multiomic center technology roadmap in the single cell space&lt;/li&gt;
&lt;li&gt;Develop and optimize high throughput low cost single-cell perturbation sequencing technologies and workflows in-house&lt;/li&gt;
&lt;li&gt;Evaluate and implement commercial systems and workflows&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Stay updated on the latest developments in the fields of single cell and genomics, actively seeking out opportunities for innovation&lt;/li&gt;
&lt;li&gt;Manage projects and have responsibility for planning, tracking, and driving timely execution of research activities&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Maintain accurate and detailed records of experimental protocols, results, and conclusions&lt;/li&gt;
&lt;li&gt;Report progress and present data in internal and external meetings&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in molecular biology, biochemistry, genomics, or similar fields with 0-5 years of post-PhD experience in either academia or industry&lt;/li&gt;
&lt;li&gt;Proven record in single cell biology or related method development publications&lt;/li&gt;
&lt;li&gt;Deep expertise in molecular biology focusing on NGS assay development and various single-cell RNA sequencing workflows&lt;/li&gt;
&lt;li&gt;Demonstrated success in developing and optimizing novel molecular biology assays with strong troubleshooting skills in collaboration with computational biologists&lt;/li&gt;
&lt;li&gt;Strong project management and organizational skills with the ability to plan, execute, and deliver results on time&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability and desire to work in a fast-paced environment and be both an independent thinker and a highly-collaborative team player&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with CRISPR-Cas9 or other genome editing technologies and hands-on Perturb-seq experience is a strong plus&lt;/li&gt;
&lt;li&gt;Experience with the development of a novel single cell tool, both wet lab and dry web is a strong plus&lt;/li&gt;
&lt;li&gt;Experience with single cell epigenetics or multiomic readout is a plus&lt;/li&gt;
&lt;li&gt;Familiarity with current single cell bioinformatic tools and ability to analyze large and complex sequencing data sets using Python, R, or similar tools is a plus&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The base salary range for this position is $121,500 to $134,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking an exceptional scientific leader and researcher to build and manage the Cellular Models Center, one of the foundational Technology Centers at the Arc Research Institute. The Center will be internally funded and staffed by professional research scientists, with the overall mission of developing cellular models to study human disease.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The center will be focused on developing and applying advanced human multi cell-type models to initially model Alzheimer’s disease and other neurodegenerative disorders using cutting edge genetic screening approaches. The center will play a key role in our Institute-wide Alzheimer’s initiative that is a highly collaborative and ambitious effort across other Tech Centers as well as Core Laboratories at the Institute for high-throughput interrogation of disease mechanisms via investigation of the role of human genetic variants using gene editing and functional genomics, and eventual development of rational therapeutic strategies.&lt;/p&gt;
&lt;p&gt;In addition, the center will engage in diverse collaborations with other Tech centers and Laboratories to develop and apply other human cellular models to investigate other complex diseases, including immune-related conditions as part of our overall mission.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are a scientific leader in developing and applying advanced human cellular models to investigate biology and disease.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You think about gaps in this space and are excited to push the scientific frontier both on model development as well as model application to generate physiologically relevant and mechanistic insights.&lt;/li&gt;
&lt;li&gt;You are a collaborator. You’re an expert in your domain and you greatly enjoy working successfully with scientists from other teams, labs and scientific domains to do more exciting science together.&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You love to learn. You love learning new skills and new domains in addition to staying up-to-date on the latest in your field.&lt;/li&gt;
&lt;li&gt;You are a mentor. Being a great scientific leader doesn’t stop at hiring your team. You love mentoring and developing people both professionally and scientifically – both in your team as well as other scientific teams at Arc.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position, you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Build out and manage a fully funded Cellular Models Technology Center of ~15 FTEs, including the leader of the existing Stem Cell Platform with 4 team members.&lt;/li&gt;
&lt;li&gt;Actively recruit, mentor and provide guidance to research staff and develop them professionally and scientifically&lt;/li&gt;
&lt;li&gt;Partner with Principal Investigators and other Technology Centers to advance research across the Institute and create a culture of collaboration and excellence&lt;/li&gt;
&lt;li&gt;Drive forward all cellular modeling and investigation aspects of the Institute’s Alzheimer’s Initiative – including successfully managing and coordinating close collaborations with the Genome Engineering team, the Functional Genomics team, the Multi-Omics Center and the Computational tech center&lt;/li&gt;
&lt;li&gt;Develop and innovate on state of the art protocols, resources, and processes for advanced cellular modeling and applications to interrogate complex human disease that are actively deployed at the Institute and distributed to the broader scientific community&lt;/li&gt;
&lt;li&gt;Serve as a subject matter expert at Arc in key areas of focus, such as developmental biology, stem cell biology or neurobiology&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Engage in and manage varied internal and external research collaborations&lt;/li&gt;
&lt;li&gt;Present research findings at institute meetings and external scientific conferences&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Job Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD, DVM/PhD, MD, or MD/PhD in a relevant field and 10 – 15+ years of relevant experience in industry and academic settings&lt;/li&gt;
&lt;li&gt;Multiple years of people management experience leading and growing scientific teams, including several PhD level scientists&lt;/li&gt;
&lt;li&gt;Experience managing teams developing and applying advanced stem cell derived models&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience with 3D modeling approaches (e.g. organoids or assembled spheroids)&lt;/li&gt;
&lt;li&gt;Experience with applying functional and genomic analysis to derive novel biological and mechanistic disease insights from cellular models&lt;/li&gt;
&lt;li&gt;Outstanding written and verbal communication skills across project planning, publications and verbal scientific presentations&lt;/li&gt;
&lt;li&gt;The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects and enjoy working in a fast-paced team environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The base salary range for this position is $243,750-$301,150. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;and whether the compensation is internally equitable,&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/span&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Funding: Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Snr Scientist with a strong background in neurobiology to join the In Vivo Functional Genomics team inside the Mammalian Models Technology Center at Arc Institute.&lt;/p&gt;
&lt;p&gt;In this position you will play a critical role in developing two of Arc’s overarching goals: the Virtual Cell (VCI) and the Alzheimer Disease Initiatives (ADI). The VCI will integrate in vivo functional genomics approaches with predictive modeling to establish causal gene-phenotype connections and, ultimately make accurate predictions of cellular states and their response to interventions to advance our understanding of human biology.The ADI, will use functional genomics to interrogate specific genetic circuits of relevance in neurodegeneration in mammalian models of Alzheimer’s Disease (these targets are currently being nominated using large-scale screens performed by Arc’s Cellular Models Tech Center). The successful candidate will use and develop functional genomics methods to generate in vivo perturbation datasets with single-cell resolution at unprecedented scale across all brain cell types. This work will represent a milestone in understanding the genetic circuits that shape brain cellular identities and how they are misregulated in neurodegenerative processes.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;In this context, you will have the opportunity to partner closely with pioneering labs that have developed the fundamental toolbox for functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and excited about answering questions related to cell function and cell-cell communication, immunology, neurobiology and complex human diseases.&lt;/li&gt;
&lt;li&gt;You enjoy working with animal models and value the benefit this type of research brings to scientific discovery.&lt;/li&gt;
&lt;li&gt;You are excited to develop new approaches and combine different tools to answer complex questions in vivo.&lt;/li&gt;
&lt;li&gt;You are creative and are excited to try new ways of tackling problems beyond the technique/approaches you are familiar with. You enjoy stepping out of your comfort zone to learn new things and develop new experimental approaches.&lt;/li&gt;
&lt;li&gt;You work fast but detail-oriented. You are good at troubleshooting. You are careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to help.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead our in vivo screen projects in the brain with a high degree of independence and continued support from the rest of the team. Our goal is to perform genome-wide in vivo screens (loss and gain of function) across the main brain lineages (neurons, astrocytes, oligodendrocytes and microglia) using expression (Perturb-seq) and morphology (in situ sequencing) as readout of perturbation states. Your work will involve experimental planning, in vivo delivery of CRISPR libraries, readout (single-cell + spatial) and data analysis. These two last points will be performed in collaboration with the Multiome and Computational Tech Centers at Arc.&lt;/li&gt;
&lt;li&gt;Test and benchmark different genetic perturbation modalities in vivo: CRISPR-KO, CRISPRi, CRISPRa, ORF overexpression.&lt;/li&gt;
&lt;li&gt;Explore &amp;amp; develop new delivery methods (viral vectors, nanoparticles, microvesicles, etc) to enable delivery of large payloads in a tissue selective manner.&lt;/li&gt;
&lt;li&gt;Train and mentor Research Associates and establish standardized protocols for use in Arc’s&amp;nbsp; labs.&lt;/li&gt;
&lt;li&gt;Embrace the opportunity to creatively collaborate with Core Investigators on ad hoc early research projects and with other Technology Centers to push our Virtual Cell Atlas and Alzheimer’s Disease Initiatives.&lt;/li&gt;
&lt;li&gt;Keep up-to-date on advances in the field by reading the literature and attending key Conferences.&lt;/li&gt;
&lt;li&gt;Analyze data and present at meetings and seminars.&lt;/li&gt;
&lt;li&gt;The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects and enjoy working in a collaborative and fast-paced team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in biology, genetics, or another relevant field with 4+ years of experience in neurobiology.&lt;/li&gt;
&lt;li&gt;Experience working with&lt;em&gt; in vivo&lt;/em&gt; models.&lt;/li&gt;
&lt;li&gt;Extensive experience in at least two of the following areas:&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;
&lt;ul&gt;
&lt;li&gt;Large scale single-cell RNAseq profiling of brain cell types.&lt;/li&gt;
&lt;li&gt;High-throughput CRISPR screens.&lt;/li&gt;
&lt;li&gt;Brain&lt;em&gt; &lt;/em&gt;delivery methods: viral vectors, synthetic nanoparticles, microvesicles, etc.&lt;/li&gt;
&lt;/ul&gt;
&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Extensive troubleshooting experience.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work both independently and in a highly collaborative multidisciplinary environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Expertise in any of the following areas will be considered an additional asset for this role:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ability to analyze large and complex data sets using Python, R, or similar tools.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience in stereotactic surgeries.&lt;/li&gt;
&lt;li&gt;Single-cell ATACseq and other epigenomic workflows&lt;/li&gt;
&lt;li&gt;Microscopy &amp;amp; Histology&lt;/li&gt;
&lt;li&gt;Experience with mammalian models (other than mice)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;The base salary range for this position is $131,750 to $162,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Funding: Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Senior Scientist (or Scientist) with a strong background in technology development to join the In Vivo Functional Genomics team inside the Mammalian Models Technology Center at Arc Institute.&lt;/p&gt;
&lt;p&gt;In this position you will play a critical role in achieving one of Arc’s overarching goals, the Virtual Cell initiative (VCI), which aims at making accurate predictions of cellular states and their response to interventions. As part of this initiative, we will generate large-scale &lt;em&gt;in vivo&lt;/em&gt; functional genomics perturbation datasets to elucidate gene function and link genes to disease phenotypes. The VCI will integrate in vivo functional genomics approaches with predictive modeling to establish causal gene-phenotype connections that advance our understanding of human biology. This will require the development of new technologies that solve the current limitations of &lt;em&gt;in vivo&lt;/em&gt; approaches:&amp;nbsp; i) effective and precise genetic and transcriptional perturbations directly &lt;em&gt;in vivo&lt;/em&gt; and ii) comprehensive and scalable readouts of perturbed cellular states. The successful candidate will develop and advance technologies in these areas to enable large-scale &lt;em&gt;in vivo&lt;/em&gt; perturbation datasets across diverse cell types, tissues and organs.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;In this context, you will have the opportunity to partner closely with pioneering labs that have developed the fundamental toolbox for functional genomics screens, including CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, Cas13d, multiCas12a and serine and bridge recombinases.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and love developing technologies for molecular engineering or multi-modal single-cell readouts that work exceptionally well in real-world biological applications.&lt;/li&gt;
&lt;li&gt;You are excited about answering questions related to cellular identities and cell-cell communication across the fields of immunology, neurobiology and complex human diseases.&lt;/li&gt;
&lt;li&gt;You have&amp;nbsp; strong molecular biology experience, as well as deep expertise in developing methods in either of these 2 areas:&amp;nbsp; genome engineering or single-cell / spatial multi-omics readouts.&lt;/li&gt;
&lt;li&gt;You are creative and are excited to try new ways of tackling problems beyond the technique/approaches you are familiar with. You enjoy stepping out of your comfort zone to learn new things and develop new experimental approaches.&lt;/li&gt;
&lt;li&gt;You work fast while remaining detail-oriented. You are good at troubleshooting. You are careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.&lt;/li&gt;
&lt;li&gt;You love to collaborate and help others and are excited to work as part of a team. Science is a team effort, and you pride yourself in taking the initiative to help.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop new technologies to enable large scale &lt;em&gt;in vivo&lt;/em&gt; functional genomics screening projects (with a priority of applications in the brain and in immune systems).&lt;/li&gt;
&lt;li&gt;Test and develop different genome engineering and perturbation modalities &lt;em&gt;in vivo&lt;/em&gt;: CRISPR-KO, CRISPRi/a, ORF overexpression and recombinase/landing pad systems in close collaboration with other scientists at Arc.&lt;/li&gt;
&lt;li&gt;Test and develop single-cell and spatial readouts to study the effects of genetic perturbations in collaboration with the Multi-omics center at Arc.&lt;/li&gt;
&lt;li&gt;Train and mentor Research Associates and establish standardized protocols for the use by other groups at Arc.&lt;/li&gt;
&lt;li&gt;Collaborate closely with other Technology Centers and Core Investigator labs to advance our Virtual Cell Initiative and Alzheimer’s Disease Initiatives.&lt;/li&gt;
&lt;li&gt;Keep up-to-date on advances in the field by reading the literature and attending key conferences.&lt;/li&gt;
&lt;li&gt;Analyze data and present at meetings and seminars.&lt;/li&gt;
&lt;li&gt;The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects and enjoy working in a collaborative and fast-paced team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in biology, genetics, bioengineering or another relevant field.&lt;/li&gt;
&lt;li&gt;4+ years of experience developing technology in either of these two areas:&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;
&lt;ul&gt;
&lt;li&gt;Genome engineering &amp;amp; CRISPR&lt;/li&gt;
&lt;li&gt;Single-cell or Spatial omics.&lt;/li&gt;
&lt;/ul&gt;
&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Strong track record in developing innovative technologies with creative approaches&lt;/li&gt;
&lt;li&gt;&lt;em&gt;In vivo&lt;/em&gt; experience and a desire to continue working primarily &lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Expertise in molecular biology in the context of omics profiling approaches, genome engineering or functional genomics&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time&lt;/li&gt;
&lt;li&gt;Extensive troubleshooting experience and strong problem-solving skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability to drive forward highly collaborative projects with a high degree of independence from your mentor / manager&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Expertise in either of the following areas will be considered an additional asset for this role:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;High content Microscopy&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Ability to analyze large and complex data sets using Python, R, or similar tools&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $114,875-$162,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Senior Scientist with a strong background in mammalian synthetic biology and protein and cellular engineering to join the Molecular Engineering team inside the Genome Engineering Technology Center at the Arc Institute. In this position, you will lead projects focused on the implementation and optimization of molecular tools for (1) monitoring cell state dynamics in complex organoid models and (2) increasing the complexity, precision, and throughput of genetic perturbation screens in disease-relevant human pluripotent stem cell (hPSC)-derived cells. Through the development of this technology, you will play a critical role in achieving one of Arc’s overarching goals, the Alzheimer’s Disease Initiative (ADI), which aims to identify and drug rational therapeutic targets for devastating neurodegenerative disorders&lt;/p&gt;
&lt;p&gt;This position is highly collaborative and the candidate will have an unique opportunity to interface with pioneering labs that have developed the fundamental toolbox for cellular RNA export, genome engineering, and functional genomics screens.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You are passionate about science and excited about answering questions related to molecular design, genome engineering technology development, and complex human diseases.&lt;/li&gt;
&lt;li&gt;You embrace challenges and often formulate creative solutions to develop new approaches and optimize existing tools to answer complex biological questions.&lt;/li&gt;
&lt;li&gt;You understand the importance of collaboration and thrive when working with a diverse team of scientists.&lt;/li&gt;
&lt;li&gt;You have a deep commitment to data quality while working in a fast-paced environment.&lt;/li&gt;
&lt;li&gt;Your organizational skills enable you to manage multiple concurrent projects, and your curiosity and creativity drive you to continuous learning and innovation.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Collaborate closely with core labs to onboard and refine &lt;a href=&quot;https://www.cell.com/cell/fulltext/S0092-8674(23)00689-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742300689X%3Fshowall%3Dtrue&quot; target=&quot;_blank&quot;&gt;cutting edge molecular tools&lt;/a&gt; that enable non-destructive measurement of cell dynamics in disease-relevant in vitro mammalian systems, including 3D organoid models that are being used to recapitulate and probe human genetics of neurodegenerative disorders.&lt;/li&gt;
&lt;li&gt;Leverage experience in protein and cellular engineering to improve the build and function of these engineered RNA export systems, as well as the precision and efficacy of effectors for genetic perturbations in hPSC-derived cells.&lt;/li&gt;
&lt;li&gt;Collaborate with cross-functional teams at Arc to integrate molecular design and engineering seamlessly with downstream in vitro disease modeling applications.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Embrace the unique opportunity to creatively collaborate with core labs and drive additional ad hoc early research projects.&lt;/li&gt;
&lt;li&gt;Stay updated on the latest developments in the fields of mammalian synthetic biology and molecular, cellular, and protein engineering, actively seeking out opportunities for innovation.&lt;/li&gt;
&lt;li&gt;Provide mentorship and guidance to research associates within the team.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Bioengineering, Molecular Biology, Biochemistry, or a related field, with a minimum of 4+ years of postdoctoral experience in academia and/or industry.&lt;/li&gt;
&lt;li&gt;Experience with mammalian cell culture, cell line engineering, and associated techniques for construct design, cloning techniques, and characterization of genetically modified cells.&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience with and enthusiasm for applying cutting-edge molecular tools to disease modeling and function-based screening, and implementing application–driven iterative, systematic technology maturation.&lt;/li&gt;
&lt;li&gt;Protein and cellular engineering experience for applications in mammalian systems, with either directed evolution and/or arrayed, systematic rational engineering approaches.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Familiarity with techniques for stem cell and progenitor cell culturing and genetic manipulation.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work both independently and in a highly collaborative multidisciplinary environment.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills.&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ability to analyze large and complex data sets using Python, R, or similar tools.&lt;/li&gt;
&lt;li&gt;Familiarity or experience with genomic assay development and functional genomics.&lt;/li&gt;
&lt;li&gt;Familiarity with using in silico design to complement experimental based protein engineering and screening.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $131,750 to $162,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;About Arc Institute&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.&lt;/p&gt;
&lt;p&gt;While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Technology:&lt;/strong&gt; Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Support:&lt;/strong&gt; Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.&lt;/li&gt;
&lt;li&gt;&lt;strong&gt;Culture:&lt;/strong&gt; We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the position&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly skilled and motivated Senior Scientist with a strong background in neurodevelopmental biology to join the Stem Cell Platform team inside the Cellular Models Technology Center at Arc Institute. This position will play a critical role in developing and improving human pluripotent stem cell (hPSC)-based differentiation protocols for disease modeling and genetic screening applications. The successful candidate will lead projects focused on advancing our understanding of in vitro cell differentiation and brain model development applied to disease contexts, allowing the identification of potential therapeutic targets and driving innovation in the field.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About you&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;You love science and the opportunities it creates. You find excitement in the opportunity to develop novel hPSC differentiation methodologies and in vitro brain models to address challenging questions in the field of neurodegeneration and find cellular and molecular pathways/targets directly responsible for disease phenotypes.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;You are a collaborator. You’re an expert in your domain and you greatly enjoy working successfully with scientists from other teams, labs and scientific domains. You believe that working on projects with scientists from different backgrounds can lead to the most exciting and successful research.&lt;/li&gt;
&lt;li&gt;You are an optimizer. In science, there’s always a race against the clock. You care deeply about making every step of the way as close to perfect as possible but also as quick and efficient as possible.&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;In this position you will&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and improve protocols for generation of hPSC-derived cells, including neurons, astrocytes, microglia, and/or related cells.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Establish and implement novel in vitro 2D and 3D brain models leveraging expertise in neurodevelopmental biology to increase fidelity and representation of the human brain&#39;s complexity in the context of Alzheimer’s disease modeling.&lt;/li&gt;
&lt;li&gt;Execute cell-based, biochemical, and molecular biology assays to characterize and validate the identity and physiology of the differentiated cells and models.&lt;/li&gt;
&lt;li&gt;Contribute to the design and execution of genetic screens to develop new cell differentiation approaches, and to identify novel genetic factors, regulatory networks, and potential drug candidates associated with neurodegenerative diseases.&lt;/li&gt;
&lt;li&gt;Maintain accurate and detailed records of experimental protocols, results, and conclusions.&lt;/li&gt;
&lt;li&gt;Collaborate with cross-functional teams at Arc to integrate in vitro brain models into broader research and technology development programs.&lt;/li&gt;
&lt;li&gt;Stay updated on the latest developments in the field of in vitro brain modeling, actively seeking out opportunities for innovation.&lt;/li&gt;
&lt;li&gt;Provide mentorship and guidance to research associates within the team.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Neuroscience, Cell Biology or a related field with a minimum of 5+ years of postdoctoral experience in academia and/or industry.&lt;/li&gt;
&lt;li&gt;Strong focus and expertise on neurodevelopmental biology&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience developing and optimizing in vitro brain models for neurodevelopmental and/or neurodegenerative diseases.&lt;/li&gt;
&lt;li&gt;Demonstrated tissue culture experience, including knowledge of stem cells, progenitor cell handling, and differentiation into defined cell types including neurons, astrocytes, microglia, or oligodendrocytes. Human iPSC-models preferred.&lt;/li&gt;
&lt;li&gt;Troubleshooting experience, comparing, optimizing and validating protocols.&lt;/li&gt;
&lt;li&gt;Excellent written and verbal communication skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work both independently and in a highly collaborative multidisciplinary environment.&lt;/li&gt;
&lt;li&gt;Strong project management skills with the ability to plan, execute, and deliver results on time.&lt;/li&gt;
&lt;li&gt;Ability to work some weekends as needed (days off can be swapped for weekdays).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with CRISPR-Cas9 or other genome editing techniques.&lt;/li&gt;
&lt;li&gt;Experience and/or knowledge of high-throughput screening methodologies and applications.&lt;/li&gt;
&lt;li&gt;Experience making neural organoids.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The base salary range for this position is $131,750 to $162,750. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;

Working at the Arc Institute Solving hard science problems together

Ambition and vision

Curiosity coupled with pragmatic solutions

Collaboration

Compensation and benefits

Open roles

Core Laboratories

Research Associate II, Gilbert Lab

Palo Alto, CA

Scientist, Horns Lab

Palo Alto, CA

Technology Centers

Machine Learning Research Scientist

Palo Alto, CA

Scientist, Single Cell Assay Development

Palo Alto, CA

Senior Director, Cellular Models Technology Center

Palo Alto, CA

Senior Scientist, In Vivo Functional Genomics - Neuroscience

Palo Alto, CA

Senior Scientist, In Vivo Functional Genomics - Technology Development

Palo Alto, CA

Senior Scientist, Molecular Engineering

Palo Alto, CA

Senior Scientist, Stem Cell Neural Model Development

Palo Alto, CA