Arc News

Arc's Goodarzi Lab, in collaboration with the Gilbert Lab, discovered that mRNA can actively control its own expression using newly discovered "RNA switches." Arc Post Doc Matvei Khoroshkin shares a look behind the paper published in Nature Methods.

The latest research from Dr. Lingyin Li’s lab, published in Molecular Cell, reveals a previously unknown mechanism that keeps our immune system in check. At the heart of this discovery is PELI2, a protein that prevents the STING pathway from overreacting to small amounts of cellular stress.

Arc’s Hsu Lab uncovers the first natural RNA-guided recombinase that can programmably insert, excise, or invert any two DNA sequences of interest.

Introducing Evo, a biological foundation model that generalizes across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks, and generative design from molecular to whole genome scale.

“There’s a huge unmet need in reducing the mortality rate of breast cancer,” said Li. “By identifying ENPP1’s role in suppressing the body’s immune response, our research is a significant step toward providing another effective treatment for patients living with breast cancer.”

At Arc, we're investing heavily in the infrastructure and expertise required to push forward the frontier of machine learning in biology across our faculty and Technology Centers. Part of our vision to advance the use of machine learning in biomedical research is to develop and disseminate computational resources and tools that enable reproducibility and support discovery throughout the scientific community.

We’re excited to provide this update on our growing scientific community, as the latest step in our 5-year trajectory towards 15 Core Investigators, five Science Fellows, five Technology Centers, and 20 Innovation Investigators.

Next in our Arc Investigator Profiles series, we caught up with Lingyin Li. In addition to her Core Investigator role at Arc, Lingyin is an Associate Professor in the Biochemistry Department and ChEM-H Institute at Stanford, where her lab has contributed several breakthrough discoveries to transform our understanding of innate immunity. She has pioneered the development of chemical tools to better understand, manipulate, and drug immune pathways, with an eye toward harnessing innate immunity to fight cancer. Among many other honors, Lingyin was recently recognized as the 2022 recipient of the Eli Lilly Award in Biological Chemistry.

A new study published in Science from the groups of Kevan Shokat at UCSF and Luke Gilbert at Arc Institute and UCSF reports the discovery of a cellular uptake pathway specifically important for larger drug molecules composed of linked subunits. This knowledge can be harnessed to create new drugs that, although they are large and complex in order to bind optimally to their targets, are efficiently taken up by target cells.

Our mission at the Arc Institute is to accelerate scientific progress in understanding and tackling complex human diseases. We are excited to launch three parallel searches to build the other major arm of Arc: our curiosity-driven Laboratories.