Welcome to the Levy lab!

We are part of the Stanford Medicine Department of Pathology and Arc Institute.

We strive to develop new therapies for human diseases by transforming our understanding of host-environment interactions.
Levy Lab

Research Focus

The intestinal host-environment interface comprises one of the most complex ecosystems on Earth. Dietary nutrients as well as bacterial, viral, and eukaryotic microbiomes influences many aspects of host physiology, but at the same time needs to be tightly regulated by the intestinal epithelium. We are particularly interested in understanding the consequences of this interface on disease risk in the context of cancer, chronic inflammatory diseases, metabolic diseases, and post-infection syndromes. We study this interplay using three complementary fields of research.
Intestinal epithelium

Intestinal epithelium

We are exploring new functions of the intestinal epithelium in the maintenance of host-diet-microbiota mutualism. A particular focus is on the integration of cellular function with the regulation of nutrient absorption and intestinal colonization by bacteria, viruses, and eukaryotes.

Metabolites

Metabolites

We are investigating the role of dietary and microbiome-derived metabolites as regulators of host immunity and metabolism. Of particular interest is the role of metabolites in inflammatory, infectious, and neoplastic disease.

Innate immunity

Innate immunity

We are studying new modalities of innate immunity in classical and non-classical immune cells. We aim to decipher the integration of immune signaling pathways into cellular function.

Publications

Serotonin reduction in post-acute sequelae of viral infection

Serotonin reduction in post-acute sequelae of viral infection

Andrea C. Wong, Ashwarya S. Devason, Iboro C. Umana, Timothy O. Cox, Lenka Dohnalová, Lev Litichevskiy, Jonathan Perla, Patrick Lundgren, Zienab Etwebi, Luke T. Izzo, Jihee Kim, Monika Tetlak, Hélène C. Descamps, Simone L. Park, Stephen Wisser, Aaron D. McKnight, Ryan D. Pardy, Junwon Kim, Niklas Blank, Shaan Patel, Katharina Thum, Sydney Mason, Jean-Christophe Beltra, Michaël F. Michieletto, Shin Foong Ngiow, Brittany M. Miller, Megan J. Liou, Bhoomi Madhu, Oxana Dmitrieva-Posocco, Alex S. Huber, Peter Hewins, Christopher Petucci, Candice P. Chu, Gwen Baraniecki-Zwil, Leila B. Giron, Amy E. Baxter, Allison R. Greenplate, Charlotte Kearns, Kathleen Montone, Leslie A. Litzky, Michael Feldman, Jorge Henao-Mejia, Boris Striepen, Holly Ramage, Kellie A. Jurado, Kathryn E. Wellen, Una O'Doherty, Mohamed Abdel-Mohsen, Alan L. Landay, Ali Keshavarzian, Timothy J. Henrich, Steven G. Deeks, Michael J. Peluso, Nuala J. Meyer, E. John Wherry, Benjamin A. Abramoff, Sara Cherry, Christoph A. Thaiss, Maayan Levy.

CellOctober 2023

β-Hydroxybutyrate suppresses colorectal cancer

Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Hélène C. Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss, Maayan Levy

NatureApril 2022

All Publications

Team

Dr. Maayan Levy
Innovation Investigator

Dr. Maayan Levy

Dr. Maayan Levy received her Ph.D. in Immunology from the Weizmann Institute of Science. After completion of her PhD, Dr. Levy became an Assistant Professor at the Microbiology Department of the Perelman School of Medicine at the University of Pennsylvania. Dr. Levy has recently joined the Stanford Medicine Department of Pathology as an Assistant Professor and the Arc Institute as an Innovation Investigator in Residence.

Dr. Maayan Levy’s scientific mission is to understand, develop, and apply the concept of metabotherapy—the use of metabolites as vehicles and targets to prevent and treat disease. Her lab’s primary focus is on inflammatory diseases, neurological diseases, and cancer. Maayan is particularly interested in the metabolite landscape of the gastrointestinal tract, which serves as a major metabolite source for many other tissues and as an ideal entry point for the introduction of new metabolites into the organism. She is exploring the repertoire of these intestinal metabolites, their impact on whole-body physiology, and the possibility of targeting them for therapeutic interventions.

Among the recognitions that Dr. Levy’s work has received are the NIH Director’s New Innovator Award, Pew Biomedical Scholar Award, Searle Scholar Award, and Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award.

Current Members

Neta Dagan
Lab Manager

Neta Dagan

Clara Baader
Lab Administrator

Clara Baader

The Horns Lab

Marina Domingo-Vidal
Postdoctoral Fellow

Marina Domingo-Vidal

Stanford Medicine Department of Pathology

Dana Binyamin
Postdoctoral Fellow

Dana Binyamin

Stanford Medicine Department of Pathology

Xianghui Ma
Scientist

Xianghui Ma

Stanford Medicine Department of Pathology

Kecheng Han
Research Fellow

Kecheng Han

Stanford Medicine Department of Pathology

Alumni

Bhoomi MadhuPostdoctoral Fellow
Shan LiuPostdoctoral Fellow
Oxana DmitrievaPostdoctoral Fellow
Angel SolisPostdoctoral Fellow
Brittany MillerPostdoctoral Fellow
Andrea WongPhD Student
Svetlana KhoziainovaPhD Student
Madeleine SleemanResearch Specialist
Lindsay MichaAnimal Specialist
Zoe SteinbergResearch Specialist
Yoni PerlaUndergraduate Researcher
Rohan GalaUndergraduate Researcher
Neil TangalUndergraduate Researcher
Aleksandra GolosUndergraduate Researcher
Caroline LuUndergraduate Researcher
Sophia SimonUndergraduate Researcher

Contact Us

Please consider joining our mission to develop safe and effective biological AI. We will also have a lot of fun along the way. If interested, you can directly join our Stanford lab or collaborate with us through a position at Arc Institute.

Address

Arc Institute
3181 Porter Dr
Palo Alto, CA 94304
info@arcinstitute.org
Arc Institute Location