Metabolite-protein interactions define metaboproteins and their role in cellular metabolism and function. These proteins include enzymes, transporters, and effector molecules. Despite their relevance in myriad diseases, novel metaboproteins have been historically difficult to identify. Our lab discovers and characterizes metaboproteins using a metabocentric platform that spans chemistry and cell biology.

The discovery of novel metaboproteins provides a genetic handle to finely interrogate how certain metabolites impact diverse biological processes. We leverage cellular and mouse genetic models to deconvolute pleiotropic metabolites. In parallel, we investigate their role in complex diseases, such as neurodegeneration, cancer, and metabolic syndrome.