Welcome to the Medoh lab!

The Medoh lab leverages chemistry, biochemistry, multi-omics, and cellular & organismal metabolism to understand how anti-aging metabolites function to maintain cellular homeostasis and human health. We discover and characterize a vast landscape of unknown metaboproteins, which become the therapeutic targets of metabolite-inspired drugs for aging and age-related diseases.
Medoh Lab

Research Focus

1

Metaboprotein Discovery & Characterization

Metabolite-protein interactions define metaboproteins and their role in cellular metabolism and function. These proteins include enzymes, transporters, and effector molecules. Despite their relevance in myriad diseases, novel metaboproteins have been historically difficult to identify. Our lab discovers and characterizes metaboproteins using a metabocentric platform that spans chemistry and cell biology.

2

Cellular/Organismal Biology of Metaboproteins

The discovery of novel metaboproteins provides a genetic handle to finely interrogate how certain metabolites impact diverse biological processes. We leverage cellular and mouse genetic models to deconvolute pleiotropic metabolites. In parallel, we investigate their role in complex diseases, such as neurodegeneration, cancer, and metabolic syndrome.

3

Metabolite-inspired Drugs

We use metaboproteomics to systematically and efficiently reveal small molecule activators and inhibitors of novel metaboproteins. These molecules serve as tool compounds and/or prototype drugs across diverse indications. We currently focus on intractable SLC transporters with considerable therapeutic potential.

Publications

All Publications

Team

Uche Medoh
Science Fellow

Uche Medoh

Uche received his B.S. in chemistry & molecular, cellular, and developmental biology (2019) from Yale University in New Haven, CT. He completed his M.Sc. in Medicine (2021) and Ph.D. in Biochemistry (2024) at Stanford University in the laboratory of Monther Abu-Remaileh. His research focused on metabolism and neurodegeneration and culminated in the discovery of the BMP synthase. He briefly performed postdoctoral studies with Dr. Nathanael Gray at Stanford University with an emphasis on metabolite probe design. As a Science Fellow at the Arc Institute, Uche is exploring the molecular basis of metabolism and aging more broadly for the development of ‘metabolite-inspired’ treatments.

Current Members

Javier Romanelli
Graduate Student

Javier Romanelli

Stanford University Department of Chemical Engineering

Johnny Stiles
Research Associate

Johnny Stiles

Bachelor of Science, Molecular and Cellular Biology, Johns Hopkins University

Contact Us

We are looking for talented postdocs and students to join us! We are interdisciplinary across chemistry, biochemistry, cell biology, mass spectrometry, and animal physiology with a unified focus on metabolism.

Email me at uche.medoh@arcinstitute.org.

Address

Arc Institute
3181 Porter Dr
Palo Alto, CA 94304
info@arcinstitute.org
Arc Institute Location