Evo is a genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins. It uses a frontier deep learning architecture to enable modeling of biological sequences at single-nucleotide resolution, with a long context window of up to 1 million tokens. Evo is trained with 7B and 40B parameters on over 8 trillion nucleotides comprising diverse prokaryotic and eukaryotic genomes. Evo Designer enables DNA generation from nucleotide and species prompts. Coding region annotation is provided, with 3D protein visualization (ESMFold) for prokaryotic sequences. Sequences are scored for perplexity and per-nucleotide entropy.