Blog

For the first of our Arc Investigator Profiles, we caught up with our newest Core Investigator, Luke Gilbert. In addition to his role at Arc, Luke is an Assistant Professor at UCSF, where he and his lab have pioneered the development of CRISPR-based epigenome editing tools toward a better understanding of the genetics and epigenetics underlying cancer. He’s particularly known for his work in developing CRISPRi and CRISPRa technology for turning desired genes on and off, and bringing these technologies to genome-wide and combinatorial screens to map the genetic interaction landscape of human cells.

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The role that advanced technologies play in scientific breakthroughs is hard to ignore - CRISPR, induced pluripotent stem cells, and single cell sequencing transformed entire fields of research. By the same token, the barriers to achieving quantum leaps in biological understanding are often technical in nature.

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Biomedical innovation in areas such as mRNA technology, gene editing, and cell therapies suggest that historic medical breakthroughs could be achieved in the years ahead. While the prevailing organizations for scientific research have yielded tremendous successes, we also believe that many important discoveries will be enabled by new research models. To accelerate scientific progress, we are launching the Arc Institute, a new scientific institution dedicated to the study of complex human diseases.

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